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Biomedical subjects

T Oka

Publications and source records attributed to T Oka.

At least 1,405 records · Page 78Linked to original sources
PubMed1972

Is prolactin mitogenic for mammary epithelium?

Prolactin administration to mature virgin mice leads to prolilferation of epithelium of the mammary gland. In organ culture, prolactin is not mitogenic, but insulin and insulin-free serum are. These observations are reconciled by the finding that insensitive epithelium is sensitized to insulin and/or serum by prolactin treatment in vivo. Thus, it appears that prolactin acts indirectly as a mitogen by rendering the cells susceptible to the aforementioned mitogens.

Aminoisobutyric Acids↗
PubMed1972

Turnover of phospholipids in an unsaturated fatty acid auxotroph of Escherichia coli.

The membrane phospholipids of an unsaturated fatty acid auxotroph of Escherichia coli were found to undergo turnover. These phospholipids were excreted into the culture medium, and were replaced in the cell with newly synthesized phospholipids. Phospholipids of growing cells supplemented with elaidic acid underwent rapid turnover, while those of cells supplemented with oleate, or cis-vaccenate plus palmitoleate, underwent slow turnover. Starvation for required amino acids stimulated this turnover in the latter two cases. Protein was also lost from growing cells. However, after amino acid starvation this loss ceased while phospholipid turnover continued. Electron micrographs of growing cells indicated that large pieces of membrane-like material were separating from the cell surface.

Amino Acids↗