Search PubMed⌕ Search

Biomedical subjects

T Oka

Publications and source records attributed to T Oka.

At least 667 records · Page 37Linked to original sources
PubMed1993

Immunohistochemical localization of epidermal growth factor in human main and accessory lacrimal glands.

Immunohistochemical localization of epidermal growth factor (EGF) in human main and accessory lacrimal glands has been investigated using monoclonal and polyclonal antibodies. Positive stain of EGF was localized in the cytoplasm of the acinar cells and the epithelial cells of the intra- and interlobular ducts of the main lacrimal glands, including both the palpebral and orbital lobes, and of the accessory lacrimal glands (gland of Krause, gland of Wolfring) as well. Meibomian glands showed weak immunoreactivity. Positive stain in the conjunctival epithelium including goblet cells was not observed. These results suggest that the mature form of EGF is produced in both the main and accessory human lacrimal glands and secreted into the tear fluid as a constant and crucial component.

Aged↗
PubMed1993

[A case of complete remission of metastatic skin carcinoma (erythema type) from advanced gastric cancer by CDDP administration].

A 75-year-old female with skin metastasis from advanced gastric cancer (portion A, tub2, ss beta, n2, P0H0, Borrmann 3-type) was successfully treated with CDDP at a dosage of 25 mg/body every week or two. She had undergone R2 curative subtotal gastrectomy in October 1986, and had orally taken tegafur 300 mg/day as postoperative adjuvant chemotherapy. Three years after the operation, she had skin erythema at chest and neck. A pathological examination revealed that the skin erythema was a metastasis of gastric cancer. After administration of 5-FU and MMC, the skin lesion diminished in size, but in November of 1990, it expanded again. Administration of 5-FU, MMC and epirubicin was not effective. The skin lesion expanded extensively and changed to nodular type. CDDP was intermittently administered from August 1991 to December 1991, 25 mg/body div. every week or two; the total volume of CDDP reached 225 mg. The metastatic skin carcinoma disappeared and a complete response was obtained. CEA, which had been high (190 ng/ml), regained the normal level. Thrombocytopenia and liver dysfunction developed as side effects, but reduced after cessation of CDDP administration. The patient has been well for 3 years and 6 months since the onset of the skin metastasis.

Adenocarcinoma↗
PubMed1993

[Thoracoscopic partial resection of the lung by use of Nd-YAG laser and standard suturing technique].

The patient was a 62-year-old woman who was referred to our department for bilateral diffuse abnormal shadows along with a sigmoid colon cancer that had been resected one month previously. Thoracoscopic partial resection of the left S8 region was performed. Nd-YAG laser with a contact tip was used for the resection. Hemostasis at the bed of the resection was assured by applying a free laser beam to oozing and non-coagulated surface. Additionally, the resected end was closed by standard continuous double over-and-over sutures in order to minimize the air leakage. Endo-Bulldog clamp facilitated the operation, minimizing hemorrhage from the resected end. This device can clamp any part of the lung and save one percutaneous puncture site necessary for thoracoscopic procedures. Postoperative course was uneventful. Pathological diagnosis was reported as an alveolar cell carcinoma of the lung.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1993

[A case of renal cell carcinoma effectively treated by interferon-alpha and embolization of the renal artery].

A case of renal cell carcinoma effectively treated by interferon-alpha and the embolization of the left renal artery is reported. A 69-year-old man was referred to us because of a left renal mass. We made a diagnosis of a left renal tumor with tumor thrombus in the renal vein and inferior vena cava, and multiple lung metastases by imaging examinations. At first the embolization of the left renal artery was selected and interferon-alpha treatment was performed for 3 months. At 3 months after the embolization, the metastatic lung tumors had completely disappeared and the left renal tumor and the tumor thrombus were reduced in size, so that left radical nephrectomy was performed. Pathological examination revealed that a small part of the tumor was viable renal cell carcinoma. After the operation, interferon-alpha treatment has been continued for 15 months and recurrence and metastasis have not been detected.

Aged↗
PubMed1993

[A case of mitral valve re-replacement with radical correction of Bland-White-Garland syndrome].

A case of an 8-year-old girl with Bland-White-Garland syndrome (BWG) who successfully underwent a second mitral valve replacement is reported. The patient had a past history of mitral valve replacement under the diagnosis of mitral regurgitation and pulmonary hypertension at one year and 3 months of age. Cardiac catheterization at 6 years and 3 months of age revealed an anomalous origin of the left coronary artery from the pulmonary artery but she was asymptomatic. One year and 7 months later, she was admitted to our institution with a sudden onset of chest pain and respiratory distress. Right heart pressure study using a Swan-Ganz catheter showed severe pulmonary hypertension and elevated mean pulmonary wedge pressure (38 mmHg). Echocardiogram revealed severe mitral stenosis and moderate regurgitation. She was diagnosed under fluoroscopy as acute left cardiac failure due to stuck valve and suspected having myocardial damage due to BWG, thus, emergency surgery was performed. Under cardiopulmonary bypass, aorto-left coronary arterial continuity was established by intrapulmonary arterial tunnel using Hamilton's technique. After resection of the prosthetic valve, of which one of two leaflets had been fixed in pannus, re-MVR was done with a St. Jude. Medical valve (25 mm). Postoperative angiogram demonstrated satisfactorily reconstructed two coronary artery systems. Postoperatively, she has been doing well without complaint for the last eighteen months.

Child↗
PubMed1993

The effects of cyclosporin on renal microsomal cytochrome P-450 systems.

The effect of CsA on the renal microsomal cytochrome P-450 system was examined by using two animal models. Male Lewis rats and male white rabbits were treated with olive oil alone (Group A) or with CsA (30 mg/kg/day, Group B) by oral gavage for 7 and 14 days. Blood urea nitrogen and serum creatinine levels were determined at serial intervals after administration of CsA. In rats, BUN and S-Cr were increased, indicating the development of nephrotoxicity in group B by the 14th day after administration; BUN 78.8 mg/dl, S-Cr 3.2 mg/dl, but not in group A (BUN 29.3 mg/dl, S-Cr 0.7 mg/dl). In the rabbit experiments, BUN and S-Cr significantly increased in group B after 7 days of treatment but not in group A. P-450 content of the kidney microsomes prepared from rat and rabbit was examined. The renal specific P-450 content in group A was 68.8 pmol/mg protein in rats and 52.1 pmol/mg protein in rabbits, whereas those in group B showed 135.6 and 221.0 pmol/mg protein at day 14, respectively. SDS-PAGE also showed a significant increase in the content of P-450 after the CsA administration. Kidney microsomal aminopyrine N-demethylase activities were increased about 2.5 and 1.7 fold in rats and in rabbits, respectively. Monooxygenase activities for laurate and prostaglandin A1 were not significantly changed.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

A case of primary localized amyloidosis of urethra.

Amyloidosis of the urethra is a rare disease. The clinical appearance resembles carcinoma of the urethra, so that biopsy is required to make the appropriate diagnosis. Once primary localized amyloidosis of the urethra has been diagnosed, selection of the appropriate treatment for each case becomes important. We report a case of primary localized amyloidosis in the male anterior urethra. This case was treated successfully with urethral dilatation.

Amyloidosis↗
PubMed1993

[Application of cryopreserved allograft to aortic root replacement for valve detachment case due to aortitis].

A 54-year-old male who had received an aortic valve replacement with SJM 23 about 3 years before suffered from an acute cardiac failure because of the valve detachment. From his clinical course, it was diagnosed that the aortic valve insufficiency was complicated by an aortitis. We operated on him by an aortic root replacement using a cryopreserved allograft which we prepared. A donor of the allograft was 35-year-old male, died of a subarachnoidal hemorrhage. We harvested his aortic root at an autopsy and dipped it into a nutrition medium with 10% dimethylsulfoxide. Within 10 hours from his death, we froze the tissue using a program freezer and stored it in a liquid nitrogen for 7 months. After thawing it in 37 degrees C water quickly, we rinsed the graft and used for the operation. The cell viability of the graft was confirmed by a tissue culture. Indication of the allograft valve to an aortitis case is still controversial. We think the allograft is recommendable to valve detachment case due to aortitis, because the softness of the graft decreases a compliance mismatch between the graft and the patient's annulus, which may prevent redetachment. Although we felt concern about redetachment of the conduit due to the weakness of the patient's aortic annulus, no complication regarding the allograft happened at all as yet.

Aortic Valve↗
PubMed1993

[Renal autotransplantation and graft replacement for DeBakey IIIb dissecting aneurysm--a case report].

A successfully repaired case, a 53-years old man, who suffered DeBakey IIIb type dissecting aneurysm and renal dysfunction was reported. The right kidney, of which artery was originated from the false lumen, was autotransplanted to the right iliac system to improve the renal blood circulation. Then the descending aorta was segmentally replaced with the prosthesis under profound hypothermia, circulatory arrest and retrograde cerebral perfusion without cross-clamping the aortic arch. Three months later, aortography and catheterization study suggested that the reperfused left kidney resulted in renin-dependent hypertension. Kidney, therefore, was resected to improve blood pressure control. Patient recovered successfully, with no evidence of neurological complication.

Aortic Dissection↗
PubMed1993

[A case of mediastinal neurinoma originated from the left vagal nerve].

A 46-year-old man was admitted to our hospital because of an abnormal shadow on the chest roentgenogram. The operation was performed through left posterolateral thoracotomy. A tumor mass, 4.5 x 2.5 x 2.5 cm in size, was found and its origin was the left main vagal nerve 0.5 cm distal the branching root of the recurrence nerve. The tumor and a part of the left vagal nerve was resected en bloc. Pathological study revealed tha the tumor was neurinoma of Antoni A+B. Postoperative course was uneventful. This is the 34th reported case in Japanese literature of neurinoma with its origin from the intrathoracic vagal nerve.

Cranial Nerve Neoplasms↗
PubMed1993

[Curative surgery for lung cancer invading the aorta with bilateral emphysematous giant bullae: a case report].

A 56-year-old male patient who had been suffered from giant emphysematous bullae in both lungs was referred to our hospital because of newly developing left lung abnormal shadow, which was adjacent to the aorta on chest X-ray. Lung cancer invading the aorta was suspected on CT scanning and curative operation was scheduled. At left thoracotomy there were large bullae in the upper lobe, part of which covered on and stuck to the tumor mass on the aortic wall. We performed left upper lobectomy, combined with the partial resection of the aortic wall and repaired it with dacron patch using partial extracorporeal circulation with cannulations into the main pulmonary artery and the descending aorta. Pathological diagnosis was large cell carcinoma. Lung cancer invading the aorta can be safely excised using assisting circulatory devices such as extracorporeal circulation. We expect this type of operation will be widely accepted and make better results.

Aorta↗
PubMed1993

[A case of successfully operated hypertrophic obstructive cardiomyopathy in a child].

A case of surgical treatment of hypertrophic obstructive cardiomyopathy (HOCM) in a 5-year-old boy is reported. This is the youngest case in Japan. He had been diagnosed as HOCM and treated conservatively with beta-blocker and Ca-antagonist, but his complaints of dyspnea and chest oppression during efforts had increased. Cardiac catheterization showed a peak systolic pressure gradient of 110 mmHg between the left ventricle and systemic artery, and echocardiogram disclosed a systolic anterior motion (SAM) of the mitral valve and mitral regurgitation (MR). At operation transaortic septal myectomy and myotomy were performed according to preoperative findings by echocardiogram and MRI, and a marked reduction in pressure gradient and a decrease in SAM and MR were obtained. Thus, a satisfactory result can be obtained by myectomy and myotomy without mitral valve replacement in a pediatric patient with HOCM, based on the preoperative image analysis.

Cardiomyopathy, Hypertrophic↗
PubMed1993

Negative regulatory elements in the human ETS1 gene promoter.

The human ETS1 gene promoter contains binding sites for transcription factors AP1, AP2 and ETS. These factors have been previously shown to be positive regulators for the expression of the ETS1 gene. In our previous report it was inferred that the ETS1 gene promoter also contains negative regulatory elements that might balance and prevent the overexpression of the ETS1 gene product. The studies reported here show that the ETS1 gene promoter also contains binding site motifs for transcription factors PEA3 and OCT. By subjecting deletion constructs of the ETS1 gene promoter to functional analysis, two negative regulatory elements (NREs) were located: NRE1 was mapped to 230 nt at the 5' end of the promoter, and NRE2 was mapped to 350 nt located between the second OCT motif and a 120-base sequence downstream from the SacI site. These NREs can also reduce the activity of a heterogenous promoter. Gel mobility-shift assays showed that nuclear extracts from B-lymphoid (Daudi), T-lymphoid (HPB) and erthyromyeloid (K562) cells each form one major and several minor complexes with NRE1 and NRE2. The nuclear extract from promyelocytic (HL60) cells does not form complexes with either NRE1 or NRE2. The identification of NREs in the ETS1 gene promoter suggests that these elements play an important role in regulating the ETS1 gene expression in hematopoietic cells.

Base Sequence↗