Multilineage response to G-CSF in paediatric aplastic anaemia.
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Adolescent↗
Biomedical subjects
T Oguni
Publications and source records attributed to T Oguni.
[Percutaneous transluminal angioplasty of the subclavian arteries].
We studied the complications and long-term results of percutaneous transluminal angioplasty (PTA) of subclavian artery stenosis in 11 patients. In all patients but one, the systolic blood pressure before PTA in the arm on the involved side was at least 30 mmHg lower than that in the opposite arm. PTA of 11 left subclavian arteries and one right subclavian artery was attempted. Five of the patients suffered from symptoms of vertebrobasilar insufficiency as well as ischemia of the upper limb, two had only cerebral symptoms, two had only ischemia of the upper limb, and another had no symptoms related subclavian arterial lesion. Standard techniques for PTA were employed, using the femoral route eight times and the axillary route four times. Angioplasty was successful in 11 lesions (92%). In the successfully treated patients, the blood pressure in the ipsilateral arm was significantly increased after PTA. No complications occurred during or after the procedure. The patients were followed for 2-74 months (mean 25.7 months). During this time, no recurrence of the stenosis was observed, although the symptoms of vertebrobasilar insufficiency did not always improve. These results suggest that PTA is useful for treating subclavian artery stenosis.
Adult↗
Liver parenchymal changes after transcatheter arterial embolization therapy for hepatoma: CT evaluation.
We retrospectively reviewed computed tomographic (CT) findings of 118 patients with hepatoma who received sequential follow-up CT after transcatheter arterial embolization (TAE). Thirty-five patients received TAE using Gelfoam particles with cisplatin, 37 patients using Gelfoam particles and iodized oil (Lipiodol) with cisplatin, and 46 patients using iodized oil with cisplatin. Liver atrophy was observed in 33 patients, lobarly or focally, depending on the embolized area. It was frequently associated with portal vein occlusion by the tumor, usage of iodized oil, and repeated embolization therapy. The lobar atrophy was seen in patients who had portal vein occlusion and/or received repeated embolization therapy. The focal atrophy was observed in patients who were administered iodized oil. Infarction developed in four patients who had a thrombus in the portal vein and received peripheral embolization therapy using iodized oil. We conclude that liver parenchymal changes occur frequently in patients who have portal vein occlusion and/or receive peripheral embolization using iodized oil.
Adult↗
Evaluation of oil-soluble FUdR ester for transcatheter arterial treatment of hepatomas.
From January 1987 to December 1989, we performed a prospective study of transcatheter arterial chemoembolization therapy with iodized oil (Lipiodol) mixed with an anticancer agent. A new oil-soluble modification of FUdR, FUdR-C8 ester, was developed and dissolved in Lipiodol as an embolic material, which was administered to 36 patients with hepatomas. Water-soluble adriamycin emulsified in Lipiodol was used as control in 67 patients with hepatomas. Initial effects on tumors were observed as decrease of tumor size in 25.0% for the FUdR group and 17.9% for the control group. Alpha-fetoprotein decreased more than half in 41.9% of the FUdR group, and 16.1% of the ADM group. Six-month and one-year survivals were 74.2% and 46.8% for the FUdR group (median survival 317 days), whereas the control group yielded 61.0% and 28.3% survivals, respectively (median survival 191 days).
Carcinoma, Hepatocellular↗
A case of hypersensitivity syndrome resembling Langerhans cell histiocytosis during phenobarbital prophylaxis for convulsion.
The case of a two-year-old girl with generalized histiocytosis, probably induced by phenobarbital, is reported. Symptoms, including intermittent fever, systemic lymphadenopathy, maculopapular skin eruption and hepatosplenomegaly, suggested Langerhans cell histiocytosis. Laboratory examinations revealed leukocytosis with lymphocytosis and eosinophilia and a high LDH serum level, while GOT and GPT were within normal ranges. Cytological studies of lymph node and pleural effusion specimens revealed proliferation and infiltration of Langerhans cell histiocytes with eosinophilia. No histiocyte proliferation was observed in the bone marrow or skin. The clinical manifestations shown by the patient were, however, transient, and improved spontaneously after the discontinuation of phenobarbital. The case was considered to be one of phenobarbital hypersensitivity syndrome based on clinical course and laboratory findings. The mechanism and differential diagnosis of the syndrome are discussed.
Child, Preschool↗
Acute spinal cord injury: magnetic resonance imaging correlated with myelopathy.
Thirty-one patients (29 males and two females, 13-87 years of age (mean, 46.7 years] with acute spinal cord injury were studied by MR (magnetic resonance) imaging and the results were correlated with neurological findings. Magnetic resonance images were obtained with a 0.5 T superconductive MR scanner (Phillips Gyroscan S5). Initial imaging was performed within 24 hours after trauma in 13 patients, 1-7 days in 13 patients and 7-14 days in five patients. Twenty-six patients underwent follow-up examinations with MR imaging. Cord abnormalities including cord compression (23 patients), cord swelling (seven patients), and abnormal signal intensities on either T1 or T2-weighted images (26 patients) were observed on initial examination. Multivariate analysis showed that cord compression and abnormal intensities on T1-weighted images were important prognostic indicators. Hyperintensity on T2-weighted images was non-specific but correlated well with clinical recovery. Magnetic resonance imaging is useful in predicting the prognosis and for planning treatment following spinal cord injuries.
Acute Disease↗
Spinal cord compression due to ossification of ligaments: MR imaging.
A total of 108 patients with ossification of the posterior longitudinal ligament (OPLL) (n = 92), ossification of the yellow ligament (OYL) (n = 8), or both (n = 8) were examined with magnetic resonance (MR) imaging performed with 0.5-T superconductive and 0.22-T resistive units. OPLL was demonstrated as a low-signal-intensity band between the bone marrow of the vertebral body and the dural sac on T1- and T2-weighted images. Continuous cervical OPLL was easier to diagnose than segmental cervical OPLL. T2-weighted images were more useful for detection of ossification of the ligaments. OYL was recognized as an impression on the posterior dural sac. Formation of bone marrow within an area of ossification, shown as increased or intermediate signal intensity, was observed in 56% of the cases of continuous OPLL, 11% of the cases of segmental OPLL, and none of the cases of OYL. The degree of cord compression was more severe in continuous OPLL. Degeneration of the disk was frequently associated with both types of OPLL.
Adult↗
Chronic injuries of the spinal cord: assessment with MR imaging.
Seventy-six patients with persistent myelopathy secondary to chronic spinal cord injuries underwent examination with magnetic resonance (MR) imaging, the results of which were correlated with neurologic findings. Twenty-one patients received follow-up study during and after the acute stage; 55 patients were examined only at a chronic stage. Spinal cord abnormalities were seen in 48 patients according to five patterns: (a) normal signal intensity on T1- and T2-weighted images (pattern N/N, n = 28), (b) normal signal intensity on T1-weighted and hyperintensity on T2-weighted images (pattern N/Hi, n = 18), (c) hypointensity on T1-weighted and hyperintensity on T2-weighted images (pattern Lo/Hi, n = 17), (d) cord atrophy (n = 5), and (e) longitudinal syrinx formation with hypointensity on T1- and hyperintensity or isointensity on T2-weighted images (n = 8). Patients with pattern N/N had only slight neurologic damage and an excellent prognosis. Patients with pattern N/Hi had mild neurologic impairment, frequently associated with cord compression. Patients with pattern Lo/Hi had the worst prognosis. Atrophy was observed in patients with a long history of myelopathy.
Adult↗
[Lateral position of the external carotid artery].
Lateral position of the external carotid artery was seen in 17 cases (4.3%), of which 13 cases were on the right side and 4 cases on the left. It is necessary to know the lateral position of the external carotid artery for the correct diagnosis by IVDSA and doppler scanning.
Aged↗
[Cerebellar infarction; the findings of CT, MRI and cerebral angiography].
The findings of CT, MRI and cerebral angiography were analysed in 18 cases with cerebellar infarction, of which 10 were men and 8 women. The areas of infarction were as follows; PICA in 9 cases, SCA in 8 cases, AICA and diffuse type in one case each. One case had two lesions. CT showed low density areas in 15 cases after 24 hours of the onset, but an abnormality was not demonstrated in one case which had an infarction of PICA area. MRI showed a high-intensity lesion on T2 weighted image during the first and tenth day after the onset, while a low-intensity lesion on T1 weighted image and high-intensity lesion on T2 weighted image were demonstrated after seventh day. MRI revealed the area of infarction better than CT. Vertebral angiography and DSA showed narrowing or poor visualization of the cerebellar arteries in 5 cases but this finding was not shown in 3 cases which were examined by IVDSA.
Adult↗
Glucose tolerance factor stimulates 3-O-methylglucose transport into isolated rat adipocytes.
Glucose tolerance factor partially purified from yeast extract powder stimulated [U-14C]-D-glucose uptake to a level 5.6 times greater than the basal level in the absence of insulin in isolated adipocytes prepared from rats fed with normal laboratory chow. The factor also stimulated 3-O-methylglucose transport 2.2-fold from the basal level in the absence of insulin, but not in the presence of 8 nM insulin. Kinetic analysis revealed that glucose tolerance factor increased 3-O-methylglucose transport by decreasing the Ks value for 3-O-methylglucose with little change in the Vmax.
3-O-Methylglucose↗
Intraarterial catheter thrombolytic therapy for acute peripheral arterial occlusions.
Intraarterial thrombolytic therapy was performed in 36 patients with acute arterial occlusions of the extremities. Intraarterial thrombolytic therapy was effective in 19 of 24 patients (79.2%) with embolic occlusions. However, the results were poor in patients who had multiple arterial occlusions including those at sites other than the extremities. Only four of 12 patients (33.3%) with thrombotic occlusions had good initial technical results. Six patients died shortly after the thrombolytic procedure, and seven patients underwent amputation. The long-term patency rate of 21 patients who were treated successfully was 92.7% after one year and 74.6% after five years. Intraarterial catheter thrombolytic therapy was effective for embolic occlusion even when more than six hours had elapsed from the onset of symptoms. The indications for thrombotic occlusions may be limited, since associated marked atherosclerotic change was often present.
Acute Disease↗
Iotrolan: a blood-isotonic nonionic dimer contrast agent for peripheral angiography.
Twenty-four patients undergoing peripheral arteriography with iotrolan 280, a blood-isotonic, nonionic, dimeric contrast medium, were evaluated in a carefully controlled phase III open trial using a variety of objective and subjective tests of discomfort. There was almost no evidence of pain, and the patients reported that they had minimal warm sensation during injection. No abnormalities in blood chemistry or urinalysis were noted in relation to injection of the contrast medium. Opacification of the peripheral arteries was excellent in all patients. Multiple physical examinations, chemical tests, electrocardiograms, and monitoring of the blood pressure showed that iotrolan 280 was a safe and useful contrast agent for peripheral angiography.
Adult↗