Search PubMed⌕ Search

Biomedical subjects

T Ogihara

Publications and source records attributed to T Ogihara.

At least 937 records · Page 52Linked to original sources
PubMed1976

Co-existent primary hypothyroidism and isolated ACTH deficiency.

A 52 year old man is described in whom the simultaneous occurrence of isolated adrenocorticotrophin (ACTH) deficiency and primary hypothyroidism was documented by the determination of six anterior pituitary hormones by specific radioimmunoassays after suitable stimulations. The urinary 17-hydroxycorticosteroids excretion was persistently reduced and was increased by repeated ACTH injections. The low basal metabolic rate, reduced serum thyroid hormones and elevated serum thyrotrophic hormone were consistent with primary hypothyroidism. After resumption of euthyroidism, secretory reserves of growth hormone and ACTH were assessed. The growth hormone reponse to insulin-induced hypoglycaemic was normal. No rise in plasma cortisol and ACTH was observed following insulin-induced hypoglycaemia. Plasma ACTH was not augmented by iv infusion of metyrapone. The pathogenesis of two co-existent endocrine deficiencies was discussed.

17-Ketosteroids↗
PubMed1976

Changes of blood pressure, plasma renin activity and plasma aldosterone concentration following the infusion of Sar1-Ile8-angiotensin II in hypertensive, fluid and electrolyte disorders.

1-Sarcosine, 8-isoleucine angiotensin II (Sar1-Ile8-AII) was infused intravenously in 5 normal volunteers and 66 subjects with various hypertensive, fluid and electrolyte disorders. Changes of blood pressure (BP), plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were studied. In normal subjects, Sar1-Ile-AII showed pressor (agonistic) activity, which was related to both dosage and sodium intake. Hyporeninaemic hypertensive subjects (pirmary aldosteronism) showed pressor responses to a smaller dose of this compound than the dose employed in normal subjects. Hyporeninaemic hypertensive subjects and normal volunteers after 3 days of high sodium intake showed significant elevations of BP and PAC and reduction of PRA. Changes of BP, PAC and PRA in normoreninaemic subjects including those with Bartter's syndrome, renal tubular acidosis or liver cirrhosis with ascites showed reduction of BP and PAC and elevation of PRA. The results indicate that the compound has both agonistic and antagonistic activities for blood pressure; which of these is obtained apparently depends upon endogenous angiotensin II levels, as well as the dosage employed. The results in subjects with high and low PRA suggest that the compound has antagonist and agonist actions at 3 sites of angiotensin II action, i.e. peripheral vascular bed, renin release mechanism from juxta-glomerular apparatus and the zona glomerulosa of the adrenals.

Acidosis, Renal Tubular↗
PubMed1975

Serum dopamine-beta-hydroxylase activity in parents and children.

Dopamine-beta-hydroxylase (DBH), an enxyme catalyzing the final step in the synthesis of norepinephrine, is released with norepinephrine on stimulation of the sympathetic nervous system. In this study an enzymatic colorimetric method was used to assay serum DBH activity in 196 individuals of whom 169 were either the parents or children in 29 families. We examined the association of DBH with age and with hypertension and the faamilial pattern of distribution of serum DBH activity. Serum DBH activity was highest in te groups 10 to 14, 40 to 49, and over 60 years. There was no significant difference in serum DBH activity between normal subjects and individuals with hypertension in any age group. tfurthermore, there was no significant correlation of mean blood pressure with serum DBH activity with or without correction of DBH for age differences; Highly significant correlations of serum DBH activity were found in sibling-sibling pairs and in mean parent-child pairs. No significant correlations were found for father-mother pairs. These observations suggest that the contribution of heredity is more important that shared environment in determining the familial pattern of distribution of serum DBH activity. Serum DBH activity did not have a bimodal distribution in the population. Noevidence was found for a maternal influence or for sex linkage in the transmission of this trait. Our data, derived from this study restricted to families with only two generations, are not adequate to specify with confidence the mode of inheritance of DBH activity in the general population.

Adolescent↗