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Biomedical subjects

T Ogata

Publications and source records attributed to T Ogata.

At least 433 records · Page 24Linked to original sources
PubMed1986

[Respiratory care for pulmonary resection in geriatric patients with bronchogenic carcinoma].

In patients aged over 70 years with bronchogenic carcinoma, respiratory failure following pulmonary resection is the most common cause of death. Before August 1982, 23 patients over 70 were treated surgically at the National Defense Medical College Hospital. Of these 23 patients, 4 died from postoperative respiratory failure, 2 of them dying within 30 postoperative days. Since August 1982, 35 pulmonary resections have been performed in patients over 70 who have been managed with pulmonary rehabilitation, resulting in no deaths from respiratory failure. Pulmonary rehabilitation has also provided a shorter duration of atelectasis and a reduced need for bronchoscopic aspiration. We therefore consider that pulmonary rehabilitation is the respiratory care of choice in elderly patients undergoing pulmonary resection.

Aged↗
PubMed1985

The three-dimensional structure of motor endplates in different fiber types of rat intercostal muscle. A scanning electron-microscopic study.

The three-dimensional organization of the motor end plates in the red, white and intermediate striated muscle fibers of the rat intercostal muscle was observed under a field-emission type scanning electron microscope after removal of connective tissue components by HCl hydrolysis. The motor endplate of the white fiber had terminal branches (or axon terminals), which were large, long and thin, and small but numerous nerve swellings (or terminal boutons). The motor endplate of the red fiber had terminal branches, which were small, short and thick, and had large but fewer nerve swellings. The motor endplate of the intermediate fiber was intermediate in size and structure between these two. In detached nerve-ending preparations, primary synaptic grooves with slit-like openings of the junctional folds appeared on the surface of the muscle fibers. The primary synaptic grooves were more developed in the white fiber than in the red fiber, and they were intermediate in the intermediate fiber. The numerical ratio of slit-like openings was 1:1.8:3.5 in the red, intermediate and white fiber, respectively. The Schwann cells and their processes were observed on the surface of the motor endplate, with the processes covering the upper orifices of the primary synaptic grooves and sealing the terminal branches. The number of Schwann cells was usually three in the white fiber, two in the intermediate fiber and one in the red fiber.

Animals↗
PubMed1985

Scanning electron-microscopic studies on the three-dimensional structure of mitochondria in the mammalian red, white and intermediate muscle fibers.

The three-dimensional structure and arrangement of mitochondria in the red, white and intermediate striated muscle fibers of the rat were examined under a field-emission type scanning electron microscope after removal of cytoplasmic matrices by means of the Osmium-DMSO-Osmium procedure. Beneath the sarcolemma, spherical or ovoid subsarcolemmal mitochondria show accumulations. The mitochondria are numerous and large in size in the red fibers, intermediate in the intermediate fibers, and few and small in the white fibers. Paired, slender I-band-limited mitochondria were located on both sides of the Z-line and partly embraced the myofibrils at the I-band level; they occurred in all three types of fibers. In the intermyofibrillar spaces, numerous mitochondria formed mitochondrial columns. These columns were classified into two types: 1) thick mitochondrial columns, formed by multiple mitochondria each with an intermyofibrillar space corresponding to one sarcomere in length, and 2) thin mitochondrial columns, established by single mitochondria corresponding to one sarcomere in length. In the red fibers mitochondrial columns were abundant and the ratio of the thick and thin columns was almost the same, while in the intermediate fibers most of the columns belonged to the thin type. The white fibers displayed rare, very thin columns.

Animals↗
PubMed1985

Scanning electron-microscopic studies on the three-dimensional structure of sarcoplasmic reticulum in the mammalian red, white and intermediate muscle fibers.

The three-dimensional structure of the sarcoplasmic reticulum (SR) in the red, white and intermediate striated muscle fibers of the extensor digitorum longus muscle of the rat was examined under a field-emission type scanning electron microscope after removal of cytoplasmic matrices by the osmium-DMSO-osmium procedure. In all three types of fibers, the terminal cisternae and transverse tubules form triads at the level of the A-I junction. Numerous slender sarcotubules, originating from the A-band side terminal cisternae, extend obliquely or longitudinally and form oval or irregular shaped networks of various sizes in front of the A-band, then become continuous with the tiny mesh (fenestrated collar) in front of the H-band. The A- and H-band SR appears as a single sheet of anastomotic tubules. Numerous sarcotubules, originating from the I-band side terminal cisternae, extend in three-dimensional directions and form a multilayered network over the I-band and Z-line regions. At the I-band level, paired transversely oriented mitochondria partly embrace the myofibril. The I-band SR network is poorly developed in the narrow space between the paired mitochondria, but is well developed in places devoid of these mitochondria. The three-dimensional structure of the SR is basically the same in all three muscle fiber-types. However, the SR is sparse on the surface of mitochondria, so the mitochondria-rich red fiber has a much smaller total volume of SR than the mitochondria-poor white fiber. Moreover, the volume of SR of the intermediate fiber is intermediate between the two.

Animals↗
PubMed1985

Muddy lung.

A 31-year-old man, a racing car driver, was submerged in muddy water as the result of an accident. He died from respiratory failure after a 17-day clinical course. Foreign body granulomatosis and massive fibrosis of the lung were revealed at autopsy. The crystalline foreign bodies mainly were composed of silicon and ranged in size from 20 micron to 500 micron in diameter (average, 90 micron). Their distribution in the lungs corresponded to the areas of lung carnification. In this study, the authors demonstrate that near drowning in muddy water causes pulmonary silicate granulomatosis associated with carnificating fibrosis of the lung and term the pulmonary changes "muddy lung."

Adult↗
PubMed1985

[A case of immature mediastinal teratoma].

A case of mediastinal immature teratoma was treated with a multimodality approach that included surgery, chemotherapy, and radiotherapy. Serum alpha-fetoprotein at admission was elevated and changed in parallel with the therapy and tumor growth. The patient died of sudden respiratory failure 18 months after admission. Mediastinal immature teratoma with elevated serum levels of alpha-fetoprotein carries a poor prognosis, as does endodermal sinus tumor. We concluded that this condition should most probably be treated with a combination of intensive chemotherapy, surgical resection, and radiotherapy.

Adolescent↗
PubMed1985

[Adenocarcinoma of the esophagus (early stage) concomitant with lung cancer--a case report].

A case of early esophageal cancer, 2.5 cm in length, located just above the esophagogastric junction is presented. This cancer seemed to originate from the fundic gland of the esophagus, because it consisted of the submucosal invasion of well-differentiated adenocarcinoma which was almost completely covered with the squamous cell mucosa of the esophagus. This patient was referred to our clinic because of lower to be a small-cell carcinoma of the lung extending to the mediastinum. He died of the lung cancer one year after operation.

Adenocarcinoma↗
PubMed1985

[A case of simultaneous surgery for primary double cancer of the stomach and kidney].

A 46-year-old man had a general health check including an upper gastrointestinal series, gastric endoscopy and biopsy. He was diagnosed as advanced gastric cancer and hospitalized for surgery. Preoperative abdominal CT scan examination was performed, and a mass was incidentally detected in the left kidney. Further examination, ultrasound survey and selective renal angiography, confirmed a renal cancer. The patient had had no macroscopic or microscopic hematuria. Gastric resection with lymph node dissection and left nephrectomy were performed and then both cancers were radically removed. Pathologically, gastric cancer was poorly differentiated adenocarcinoma and renal cancer was carcinoma of the clear cell type.

Adenocarcinoma↗
PubMed1985

[A case of superficial esophageal cancer with metastasis to the gastric wall].

A 65-year-old man with superficial esophageal cancer associated with gastric wall metastasis is presented. He had suffered from epigastralgia and dysphagia for two months. X-Ray and endoscopic examination revealed esophageal erosion at the right wall of the lower esophagus and a large gastric submucosal tumor at the lesser curvature of the upper and middle stomach. Resection of the lower esophagus and total gastrectomy were performed. Histologically, the erosion of the lower esophagus was moderately differentiated squamous cell carcinoma invading as deep as the submucosal tissue and the tumor of the stomach was metastasis of the esophageal cancer. Intramural metastasis of esophageal cancer was discussed.

Aged↗
PubMed1984

Clara cell granules of peripheral lung cancers.

Thirty-five peripheral carcinomas of human lungs were morphologically examined in comparison with the bronchiolar nonciliated epithelium. Clara cell granules were found not only in 21 cases of papillary adenocarcinoma, including three of classical bronchiolo-alveolar carcinoma, but also two of acinar and four of solid carcinoma. The granules of tumor cells were identical to those of bronchiolar nonciliated cells on histochemical and ultrastructural levels. Most granules consisted of a monotonous and finely granular matrix, but there were variants containing fingerprint-like lamellae and small vesicles. These variants were also found in nonciliated cells of normal bronchiolar epithelium. The amount of granules was related to the degree of tumor differentiation. It is suggested that most peripheral carcinomas of the lungs have a potential for Clara cell differentiation, irrespective of whether they exhibit any histologic appearances.

Adenocarcinoma↗