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Biomedical subjects

T Obara

Publications and source records attributed to T Obara.

310 records · Page 18Linked to original sources
PubMedDate not supplied

Antibodies reacting against cytoskeletal proteins in Waldenstrom's disease.

Seventeen serum samples from patients suffering from monoclonal gammopathies (multiple myeloma, Waldenstrom's disease and idiopathic paraproteinemia) were tested by indirect immunofluorescence techniques for detection of antibodies against autoantigens. Neither serum from patients with multiple myeloma nor that from patients with idiopathic paraproteinemia showed reactions against the different antigens tested. Sera from two of six patients with Waldenstrom's diseases reacted against cytoplasmic proteins of basal and adnexal cells of squamous epithelia. One of the two also reacted with smooth muscle cells. Our studies showed that these antibodies were IgM kappa, therefore corresponding to the monoclonal component. Immunoenzymatic procedures on purified cytokeratin fixed on microtiter plates demonstrated reactions of the two sera against this protein in dilutions of up to 1:80 and 1:120 respectively. Western immunoblotting showed a specific reaction with 52 kD cytokeratin in one of the sera.

Animals↗
PubMedDate not supplied

Successful surgical treatment of pulmonary artery sling and partial anomalous pulmonary venous drainage in an infant.

A 8 month old infant with pulmonary artery sling and partial anomalous pulmonary venous drainage was reported. The patient was seen initially with severe stridor. Diagnosis was made by barium swallow study, echocardiography, bronchoscopy, and pulmonary arteriography. The patient was operated on through a median sternotomy; the left pulmonary artery was dissected deep between the trachea and esophagus, and then reimplanted to the side of the main pulmonary artery. Systemic heparinization and microsurgical technique were used. Simultaneous intracardiac repair was carried out by means of extracorporeal circulation. The patient improved dramatically after operation. Postoperative pulmonary arteriogram revealed a wide patent left pulmonary artery, and postoperative perfusion lung scan confirmed improved perfusion of the left lung. It is concluded that pulmonary artery sling should be treated surgically as soon as diagnosed. From the surgical point of view, the left pulmonary artery should be anastomosed to the main pulmonary artery with micro-surgical technique to avoid late occlusion of the left pulmonary artery.

Abnormalities, Multiple↗
PubMedDate not supplied

Efficacy of endoscopic diagnosis and treatment for postoperative biliary leak.

BACKGROUND/AIMS: The purpose of this study was to evaluate the efficacy of endoscopic approaches for the diagnosis and treatment of postoperative biliary leak. METHODOLOGY: Endoscopic retrograde cholangiopancreatography (ERCP) was performed in eight patients with postoperative biliary leak. Of 8 cases, 6 had biliary leak alone (4 cases with a cystic duct leak and 2 cases with a bile duct leak) and 2 cases with a bile duct leak were associated with a bile duct stricture. Endoscopic sphincterotomy (ES) and endoscopic biliary stenting (EBS) were employed in 5 patients and nasobiliary tube drainage (NBD) without ES was performed in 3 patients. RESULTS: In all the patients, ERCP was successfully performed and could demonstrate exact nature and site of postoperative bile duct injuries. In 2 patients with a concomitant bile duct stricture, repetitive endoprosthesis placements were required. The remaining six patients with biliary leak alone were successfully treated by temporary stenting, i.e., ES and EBS (n = 3), and NBD (n = 3). CONCLUSIONS: The patients with postoperative biliary leaks can be successfully diagnosed by ERCP and treated by temporary endoscopic methods. Among various endoscopic treatments, NBD alone appears to be preferable in treating patients with small bile leaks. However, cases with a concomitant bile duct stricture were intractable and required longer period of stenting.

Adult↗