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Biomedical subjects

T Numata

Publications and source records attributed to T Numata.

At least 109 records · Page 6Linked to original sources
PubMed1979

The role of mite allergen in chronic urticaria.

Fifty-two patients with chronic urticaria were tested intradermally with mite allergen (Dermatophagoides farinae). None had any past history of any other atopic diseases. Thirty of the 52 patients gave positive skin tests to mite allergen. A good correlation between skin sensitivity to mite allergen and in vitro mite antigen-induced histamine release from leucocytes was observed. These facts suggest that a mite may be an important role in chronic urticaria.

Allergens↗
PubMed1978

Treponema pallidum immune adherence test for serodiagnosis of syphilis. 1: An improved method of the TPIA test.

Clinical investigations using the Treponema pallidum immune adherence (TPIA) test as reported by Nelson (1953) were performed only by Olansky et al in 1954. In this paper an improved method of the TPIA test is described. The test was simple to perform and was highly specific for antitreponemal antibody. Furthermore, as it was possible to use heated T. pallidum as antigen the antigen suspension could be preserved for long periods. The TPIA test for syphilis was evaluated by examining the sera from 40 healthy subjects and from 166 patients with syphilis.

Complement System Proteins↗
PubMed1978

Treponema pallidum immune adherence test for serodiagnosis of syphilis. 2: Comparison with glass plate, TPHA, and FTA-ABS tests.

Using sera from 340 patients with syphilis the Treponema pallidum immune adherence (TPIA) test was compared with the glass plate, T. pallidum haemagglutination (TPHA), and fluorescent treponemal antibody-absorbed (FTA-ABS) tests. The results of the TPIA test agreed with those of the glass plate, TPHA, and FTA-ABS tests in 65%, 82%, and 73% of cases respectively. In the quantitative TPIA test no significant correlation with the other tests was observed, and it is, therefore, concluded that the TPIA test has highly individual characteristics. From gel filtration the particular feature of the test was its high sensitivity to the IgM antibody. The TPIA test thus appears to be suitable for estimating antibody in the early stages of the disease.

Chromatography, Gel↗
PubMed1978

Treponema pallidum immune adherence test for serodiagnosis of syphilis. 3: Clinical significance and evaluation of treatment.

Antibody titres were measured in patients with clinical syphilis, and the effect of treatment on the results of the Treponema pallidum immune adherence (TPIA) test is reported. In the Treponema pallidum haemagglutination (TPHA) test little change in antibody titre occurred after treatment while in the fluorescent treponemal antibody-absorbed (FTA-ABS) test only a slight decrease occurred. The decrease in the antibody titre in the TPIA test was similar to that in the glass plate test, but the findings were different. From the results of gel filtration of sera obtained from patients with syphilis at different intervals after treatment it was apparent that the decrease in antibody titre after treatment mainly concerned the IgM antibody; thus, because of the high sensitivity of the TPIA test to IgM antibody the test is useful in evaluating the effect of treatment.

Antibodies, Bacterial↗
PubMed1975

Physical properties of experimental vitreous membranes. I. Tensile strength.

The tensile strength of vitreous membranes, induced by silk sutures imbedded in the vitreous body and removed one to two weeks later, was investigated in rabbits. Three types of membranes were distinguished by their appearance under an operating microscope; dense, opaque, cylindrical membranes, (Type 1), broken with 2 to 16 Gm. of force and elongated from 127 to 200 per cent before breaking; thin, cylindrical membranes, (Type 2), broken with 200 mg. to 2 Gm. of force and elongated from 51 to 152 per cent before breaking; and thin film-like membranes imbedded in formed vitreous gel, (Type 3), broken with 200 mg. to 5.5 Gm. of force and elongated from 53 to 186 per cent before breaking. Vitreous membranes formed two to eight weeks after surgery resisted forces greater than those required to detach rabbit retina. The results of the experiment are relevant in the design of vitrectomy instruments.

Animals↗
PubMedDate not supplied

Effect of sex hormones on eosinophilic inflammation in nasal mucosa.

We examined the effects of sex hormones on the functions of eosinophils. Treatment of eosinophils with beta-estradiol significantly enhanced the eosinophil adhesion to human mucosal microvascular endothelial cells (HMMEC), and eosinophils stimulated by a combination of beta-estradiol and progesterone showed significant induced degranulation. On the other hand, testosterone significantly reduced the eosinophil adhesion to HMMEC and eosinophil viability. The experiments from the series of studies might provide a partial explanation for the aggravation of asthma and some forms of rhinitis that occurs during pregnancy.

Adult↗