Biomedical subjects
Publications and source records attributed to T Nozue.
In the uptake of Ca++ ions in the neural crest derivatives of the small intestine of rats during active transport of calcium, the neural crest derivatives and mast cells of senescent rat small intestine, incubated at 45 degrees C, showed elevated uptake of CA++ ions and increased cell death compared to younger rats.
In suckling mice injected intraperitoneally with mitomycin C, endotoxin, hydrocortisone and androgen, excessive, proliferation of blood cells was found in the blood vessels and in the sites where neural crest cells and non-staining spindle shaped neural crest cells may be present. It is speculated that these phenomena may be related with the cell surface properties of neural crest cells in the G1 phase of the cell cycle through the system mediated by cyclic AMP, and that the non-staining spindle-shaped neural crest cells in the blood vessels may be the hemopoietic stem cells.
In suckling mice injected i.p. with a 27 mg/kg dose of L-hydrochloric acid isoproterenol, multiple neural crest tumors developed and cell death of neural crest cells occurred. It is speculated that neural crest derivatives may be beta-receptor cells and contain regulatory units of neurotransmission mediated through cyclic AMP.
Neural crest cells in the pre- and postnatal development of mice showed a specific sensitivity to mitomycin C. In mice injected with mitomycin C 24-48 h after birth and surviving up to the 9th day, a free or attached denticle in the pulp and a fibroma or excessive cell proliferation in the dental follicle or the periodontal ligament were seen; further, a dentinoma developed.
In suckling mice injected with steroids, multiple tumors occurred in the sites where neural crest cells normally are present. It is speculated that the phase of the cell cycle of the neural crest cells may have something to do with its cell surface and cellular phenotypic expression in the system mediated by cyclic AMP.
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In suckling mice injected intraperitoneally with mitomycin C on the 1st to 5th day after birth and sacrificed in the course of 24 or 48 h after injection, mastocytosis occurred in the oral mucosa membrane, skin of the trunk or extremities and bone marrow of extremities.
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