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Biomedical subjects

T Noto

Publications and source records attributed to T Noto.

At least 109 records · Page 6Linked to original sources
PubMed1982

Thiolactomycin, a new antibiotic. III. In vitro antibacterial activity.

Thiolactomycin is a new broad-spectrum antibiotic, active in vitro against many species of Gram-positive cocci, Enterobacteriaceae, Haemophilus, acid-fast bacteria and anaerobic bacteria. However, the activity is generally moderate and bacteriostatic in action. This antibiotic eludes cross resistance with any of the known antibacterial drugs such as ampicillin, carbenicillin or cycloserine. The effect on Gram-negative bacilli in vitro is little affected by the inoculum size, the presence of horse serum, the pH of the medium or the type of medium. When thiolactomycin was added to the assay medium, the minimum inhibitory concentration of ampicillin against inducible beta-lactamase producing strains of Staphylococcus aureus and Pseudomonas aeruginosa was reduced. Thiolactomycin inhibited the production of inducible beta-lactamase in several organisms.

Anti-Bacterial Agents↗
PubMed1982

Thiolactomycin, a new antibiotic. IV. Biological properties and chemotherapeutic activity in mice.

The new thiolactone antibiotic, thiolactomycin, is rapidly absorbed in rats when administered either orally or by intramuscular injection. A peak in concentration of the drug is reached in the blood and in various visceral organs within 15 minutes after administration. The concentration decreases rather rapidly and about 51-69% of the drug is excreted in urine during the first 24 hours. Though the in vitro effect of thiolactomycin is moderate, it effectively protected mice challenged intraperitoneally with several strains of S. marcescens and K. pneumoniae and more effective than carbenicillin in treating experimental acute urinary tracts infected with S. marcescens. Also, in mice whom immunodefense was decreased by treatment with cyclophosphamide, thiolactomycin was more effective than carbenicillin against S. marcescens challenge.

Animals↗
PubMed1982

Cyanocycline A, a new antibiotic. Taxonomy of the producing organism, fermentation, isolation and characterization.

A new antibiotic, cyanocycline A, was isolated from the fermentation broth of Streptomyces flavogriseus strain No. 49, a soil isolate. The molecular formula of cyanocycline A was determined to be C22H26N4O5. The antibiotic has a cyano group and a N-heterocyclic quinone moiety in its structure. Cyanocycline A was found to have broad spectrum antimicrobial and antitumor activity.

Animals↗
PubMed1982

Analysis of the tissue and cellular localization of alpha-1-antichymotrypsin by an immunohistochemical technique.

The cellular localization of alpha-1-antichymotrypsin (alpha 1-ACT) was studied immunohistochemically using rabbit HRP-labeled Fab' against human alpha 1-ACT. alpha 1-ACT was found in cell nuclei of carcinomas of the stomach, liver, breast, pancreas and leiomyosarcoma and in cell nuclei of lymphoid cells infiltrated into the stomach carcinoma mass. alpha 1-ACT was not found in carcinoma cells of the colon, uterus, rectum or esophagus, or in lymphoid cells infiltrated into the rectal carcinoma mass or into inflammatory regions such as gastric ulcers or appendicitis. Further, alpha 1-ACT was not found in normal cells around the carcinoma mass or in normal tissues.

Breast Neoplasms↗
PubMed1982

Evaluation of usefulness of serial AMHTS--from the viewpoint of inpatients in our hospital.

We studied the relation between admission after check-up and check-up frequencies of AMHTS examinees in our hospital in order to evaluate the usefulness of serial check-ups. Follow-up studies were performed on a total of 16,630 examinees and continued until March 1982. There were 558 inpatients, 3.4% of the total. The main reason for their admission was cancer, followed by diabetes mellitus and chronic hepatitis. It was shown that the admission rates of examinees decreased as the check-up frequencies increased the examinees under 60 years old, but not for those over 60 years of age. In addition, both admission and cancer rates of AMHTS examinees decreased on the whole as their check-up frequencies increased.

Adult↗
PubMed1980

Isolation and identification of polyamine metabolites in urine of animals.

Fractionation of urinary metabolites of radioactive polyamines in rats yielded four fractions containing (A) non-polar and acidic compounds, (B) acidic and neutral ampholytes, (C) basic ampholytes, (D) polyamines, respectively. A large amount of radioactivity was found in Fractions A and D from rats injected with putrescine, and in Fractions C and D from rats injected with spermidine or spermine. Analysis indicated that gamma-aminobutyric acid, N-monoacetylputrescine, 2(3)-hydroxyputrescine, putreanine, N-(3-aminopropyl)-4-aminobutyric acid (isoputreanine), spermic acid, N-(3-aminopropyl), N'-(2-carboxyethyl)-1,4-diaminobutane, and N-monoacetylspermidines A and B were excreted as urinary metabolites. The possible significance of the findings is discussed.

Animals↗
PubMed1979

Effects of vasopressin and cyclic AMP on water transport at arachnoid villi of cats.

The effects of vasopressin and cyclic AMP on water transport at arachnoid villi into the superior sagittal sinus were examined using the isolated meninges preparations of cats. The meninges preparation, the superior sagittal sinus of which was opened at the midline of the outer surface, was held between two polyethylene tubes. The tubes were fixed vertically in the way that the opened surface of the sinus was directed downward and arachnoid surface upward. Water transport was determined by measuring the tritiated water dripping through the membrane preparation. Vasopressin from less than 50 to 500 muU/ml accelerated the water transport and this effect was dose-dependent. Cyclic AMP from 0.5 to 10 mM was proved to manifest the same effect as vasopressin. This effect of cyclic AMP appeared rapidly in comparison with that of vasopressin, suggesting that the effect of vasopressin may be manifested through cyclic AMP. From these findings a physiological role of vasopressin in cerebrospinal fluid was discussed regarding the regulation of intracranial pressure.

Animals↗