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Biomedical subjects

T Nose

Publications and source records attributed to T Nose.

At least 361 records · Page 20Linked to original sources
PubMed1980

[Chronic subdural hematoma--changed its density from low to high on follow-up CT (author's transl)].

Recently much attention has been paid once again to etiology of chronic subdural hematoma since the appearance of computed tomography (CT). Authors examined 1824 head injury cases by CT from January 1977 to September 1979. Among them, there are 40 cases (they were all over 16 years old) whose CT showed frontal extracerebral low density area. The low density area which is considered to be so-called fluid collection could be classified into four types (type I to IV). In two cases of those 40 cases (5%), the low density area changed into high density area which seemed to be hemorrhage. The 2 cases were diagnosed to be chronic subdural hematoma and proved surgery. The change of density on CT developed only from type I (the brain surface looks smooth and sulci are not recognized beneath the low density area). The change of density, occurred in 2 cases among 24 cases of type I (8.3%), was recognized about 2 months after the head injury. This fact is compatible with the report by Yamada et al. (1979). Thus, when CT after the head injury shows frontal extracerebral low density area of type I, the case may develop to chronic subdural hematoma about 2 months after the head injury. Therefore, careful observation should be needed especially during this period after the head injury.

Adult↗
PubMed1980

[Spontaneous spinal epidural hematoma--report of a case (author's transl)].

A typical case of spontaneous spinal epidural hematoma was reported. The patient was a 52 year-old male. He suddenly developed severe high back pain followed by complete paraplegia and rectovesical insufficiency. Myelography disclosed epidural mass extending fro Th2 t0 Th4. Laminectomy and removal of hematoma were carried out 4 days after the onset. Post-operative course was uneventful. Four months later he began to walk with the aids and 7 months later he was fully ambulatory and discharged. We analysed 110 cases already reported including our own and obtained the following conclusions. Spontaneous spinal epidural hematoma was 67% and secondary one 33%. The most frequent precipitating factor was usage of anticoagulant followed by trauma and vascular anomaly. There were relatively many case below the age of 15. The level of lesion predominated in thoracic region. Early operation was imperative but even in delayed cases good result could be expected especially in younger patient and those with lumbal lesion.

Age Factors↗
PubMed1980

[Computed tomography in diagnosis and management of acute head injury--correlation between clinical symptoms and CT findings (author's transl)].

A series of 202 patients with acute head injuries was investigated in correlation with clinical signs and computed tomographical findings. Clinical signs were classified into four types according to ARAKI's grading. Ninety three cases of type I, 61 cases of type II, 41 cases of type III and 7 cases of type IV were included in this series. The youngest patient was 40 days old and the oldest was 83 years old and average age was 31.3 years old. Initial C.T. was carried out in 70.80% of this series within 2 days after injury. Conclusions were obtained as follows: 1) Intracranial hemorrhages were recognized in 5.4% of type I, 18.0% of type II, 68.3% of type III and 100% of type IV on C.T. 2) All of intracranial hemorrhage in type I and type II were small and limited ones and showed no mass effect on C.T. 3) In all of severe cases with deep coma, their C.T. demonstrated poor visualization of so-called pentagone, ambient cistern and quadrigeminal cistern. These findings especially that of quadrigeminal cistern image were considered to be signs of poor prognosis. 4) Incidence of visualization of Sylvian fissure decreased in order of type I, type II, type III and type IV on C.T. Poor visualization of Sylvian fissure may reflect of small lesion in or out of cortex near Sylvian fissure such as small intracerebral hemorrhage, localized brain edema, small epidural hematoma etc. 5) Incidence of visualization of sulci decreased in order of type I, type II, type III, and type IV. Poor visualization of sulci may reflect existence of small lesion in or out of cortex in vertex area. 6) False negative of false positive finding on C.T. can result from slice level or time of C.T. and/or age of patient. Repeated C.T. may be recommended when the patient has conflicting neurological signs for these C.T. findings.

Adolescent↗
PubMed1979

[Computed tomography in metastatic brain tumors and meningeal carcinomatosis (author's transl)].

The computed tomogrpahy has been proved to be highly reliable in diagnosis of CNS diseases. The findings in 26 cases of metastatic brain tumors, and 2 cases of meningeal carcinomatosis performed with Hitachi CT-H scanner are analized. Metastatic tumors are seen on plain CT as mainly isodense nodules (60%). But, on enhanced CT, they increase in their density (97%). Larger nodules of metastatic tumors (over 2 cm in diameter) are tend to contain less dense central area, so called central cavitation. The direction of the expansion and/or extension of the perifocal low density is characteristic to the location of the tumor. In cases of meningeal carcinomatosis, diffuse periventricular higher density can be recognized enhanced CT.

Adult↗
PubMed1977

Responses to the postural change and orthostatic dysregulation symptoms: a population study on Japanese junior and senior high school students.

Unselected 580 male and 779 female junior and senior high school students were subjected to the tilting test and informations on 11 autonomic dysregulation symptoms and complaints were taken by interviews. Results of the analyses of the data are summarized as follows: 1) Number of symptoms and complaints possessed by each individual distributes continuously but nonrandomly among testees; that is, individuals having no symptom and those having 5 or more symptoms are significantly more numerous than those expected from random distribution, indicating accumulation of the symptoms into some individuals. 2) Some specific symptoms tend to coincide with each other. 3) Principal component analyses disclosed that the first principal component can explain only 16-20% of the observed variation in the presence or absence of symptoms and complaints, suggesting that numerous factors are responsible for the occurrence of the symptoms. 4) Measurements of the blood pressures and the pulse rate, and their responses to the postural change show continuous, normal distributions, and significantly correlate to each other. 5) The responses to the tilting test are increased with the increase of number of symptoms and complaints possessed by the testees.

Adolescent↗
PubMed1976

Clinical and radioisotopic follow-up study of 'Moyamoya'.

24 children with 'moyamoya' had average follow-up periods of 5 years and 9 months. The following factors were noted to influence the prognosis for mental function: early onset, repeated transient ischemic attacks followed by residual neurological deficit, symptoms suggesting bilateral or dominant hemispheric lesions, and angiographically widespread occlusion. Futhermore, radioisotopic procedures could replace angiography for follow-up studies of patients with Moyamoya.

Adolescent↗
PubMed1976

[Characteristics of brain scintigraphy in pediatric age group and its diagnostic value in brain tumors (author's transl)].

The diagnostic value of brain scintigraphy in intracranial diseases has been well recognized. Numerous reports have appeared in the literature concerning its use in adult cases. The reports dealing with pediatrics cases, however, are quite limited in number. The major factors limiting such studies in children may be considered as follows; (1) infratentorial tumors are common in this age group, in which its diagnostic accuracy has been believed to be quite low, (2) problems of exlosing children to radiation and (3) difficulty in keeping children in one position for a considerable length of time. These difficulties were almost overcome by the use of 99m Tc with a very short half life and a gamma camera, resulting in increased application of this procedure to children. The purpose of this report is to analyse and discuss the scintigraphical characteristics in children and evaluate the diagnostic value in brain tumors. The subjects consist of 199 non-tumoral cases and 53 cases of verified brain tumors. Following conclusions were obtained: (1) Aging changes are noted in normal brain scintigrams of children. One of them is related to the mode of visualization of the basal structures in lateral views. The cranial base appears to be flat before the age of 4 years. A triangular process then appears at the cranial base, approaching that of adult over the age of 10 years. Another change is related to appearance of the temporal and occipital muscles over the cranial vault and the posterior fossa. This becomes apparent about the age of 7 years and produces such masking effects as to interfere with diagnosis in this region over the age of 10 years. (2) The choroid plexus are visualized in about 10% of cases. (3) In brain tumor cases, the detecting rate is 93% in gliomas, and 73% in non-gliomatous tumors. It is particularly low in congenital tumors.

Adolescent↗
PubMed1975

The effect of penfluridol and some psychotropic drugs on monoamine metabolism in central nervous system.

Five neuroleptics: penfluridol, haloperidol, chlorpromazine, pimozide and oxypertine, and two benzodiazepine minor tranquilizers; chlordiazepoxide and diazepam, were studied in mice and rats. When the drugs were injected i.p. in mice, all neuroleptics increased the brain homovanillic acid (HVA) concentration but two benzodiazepines did not change it. Of the drugs tested, only pimozide increased the brain level of 5-hydroxyindoleacetic acid. Penfluridol accelerated the turnover rate of brain dopamine (DA), wheras haloperidol accelerated both DA and noradrenaline turnover rates. In rats, oral administration of penfluridol caused an increase in the striatal HVA and 3,4-dihydroxyphenylacetic acid which persisted longer than that following haloperidol. The concentration of brain 3-methoxy-4-hydroxyphenylethylene glycol, however, was not affected by penfluridol even when the drug was administered at a high dose. Based on these and earlier findings, it is concluded that the effect of penfluridol on DA metabolism resembles that of typical neuroleptic compounds and penfluridol acts only on DA neurons as a long-acting DA receptor blocker.

3,4-Dihydroxyphenylacetic Acid↗