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Biomedical subjects

T Noro

Publications and source records attributed to T Noro.

103 records · Page 6Linked to original sources
PubMedDate not supplied

Cytoplasmic inclusion bodies and minimal hepatitis: fibrinogen storage without hypofibrinogenemia.

A 12-year-old Japanese boy had chronic elevation and fluctuation of serum transaminase levels since infancy, with no signs or symptoms of liver failure. Usual infections or metabolic disorders were eliminated from consideration. No coagulopathy or abnormality in plasma concentrations of clotting factors was found. Light microscopy of liver biopsy specimens obtained at ages 2, 5, and 7 years showed slight hepatocyte disarray and minimal mononuclear-leukocyte lobular inflammation, with eosinophilic inclusion bodies in the cytoplasm of hepatocytes throughout the lobule. These bodies stained with the periodic acid-Schiff (PAS) technique; the PAS-positive material was partly diastase digestible and on immunostaining marked for fibrinogen but not for alpha 1-antitrypsin. On transmission electron microscopy, the bodies were represented by finely granular material contained within membranes and were interpreted as tentatively endoplasmic reticulum. Fibrinogen storage may be manifest as minimal hepatitis without coagulopathy.

Afibrinogenemia↗
PubMedDate not supplied

Biliary tract infection with anaerobes and the presence of free bile acids in bile.

Gallbladder bile from 24 patients (five with anaerobic biliary tract infection, 10 with aerobic biliary tract infection, and nine without biliary tract infection) was examined by thin-layer chromatography (TLC) for the presence of free bile acids. All five patients with an anaerobic biliary tract infection had small amounts of free bile acids in gallbladder bile. Seven of 10 patients with aerobic biliary tract infection and nine patients with sterile bile had no detectable free bile acids. Minute amounts of free bile acids were detectable on TLC in bile of three patients with aerobic infections. Calcium bilirubinate stones were more common in patients with free bile acids in bile.

Bacteria, Anaerobic↗