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Biomedical subjects

T Nomiyama

Publications and source records attributed to T Nomiyama.

66 records · Page 4Linked to original sources

Hematemesis and melena: Endoscopic examination.

Today, gastrointestinal endoscopy has become a routine examination. In our "Endoscopy center", about five hundred gastroscopies are performed every month. It has been said in many reports that endoscopy, especially emergency endoscopy, is an effective method of discovering sources of bleeding. In this report, we also emphasize that emergency endoscopy is effective in diagnosing upper gastrointestinal bleeding on the basis of reviewing 318 endoscopic examinations.

Adolescent↗

Hematemesis and melena: Mallory-Weiss syndrome.

The records of 29 patients with Mallory-Weiss tears diagnosed by endoscopy are reviewed. Ingestion of alcohol was a chief cause of bleeding. Single tears were the largest in number and 68% of the lacerations were seen just distal to the esophago-cardial junction. Lacerations occurred more frequently on the right lateral wall of cardia than on the left lateral wall. Most of these lesions were mild and could be treated medically except for two cases which were surgically treated.

Adolescent↗

Hematemesis and melena: gastric ulcer.

Differences in distribution of age, hemoglobin values, location and number of ulcers, activities of gastric secretion, associated conditions, treatment and prognoses between bleeding and non-bleeding gastric ulcer patients were studied. The ages of bleeding patients were distributed more widely than those of non-bleeding patients and the number of patients over 70 years of age was greater in bleeding patients than in non-bleeding patients. Associated conditions of bleeding patients were more serious than those of non-bleeding patients and some bleeding patients showed coagulation disorders. Fifteen out of 17 bleeding patients were treated and well controlled surgically, and seven out of 62 bleeding patients who were treated medically died. In this study, the exact cause which made the difference between bleeding ulcers and non-bleeding ulcers could not be found. Bleeding ulcer patients with associated conditions did not always die directly from bleeding, but the bleeding decreased their general condition and, as a result, they died. Therefore, surgical treatment is the first choice in these patients if their conditions will tolerate such treatment.

Adult↗

The therapeutics of peptic ulcers: clinical evaluation of C-Fe therapy.

Ascorbic acid and ferrous sulfate were given to peptic ulcer patients (C-Fe therapy). In gastric ulcer patients, the healing index of the C-Fe therapy group was significantly higher than that of controls, but in duodenal ulcer patients, no significant difference was observed between the healing index of the C-Fe therapy group and that of controls. According to these results, it was concluded that C-Fe therapy was effective in healing gastric ulcers and that the cause of duodenal ulcers might depend more on aggressive factors than that of gastric ulcers.

Adult↗

Serum CEA levels in gastrointestinal diseases.

Preoperative carcinoembryonic antigen (CEA) levels in 36 colorectal carcinoma patients were corrected in accordance with pathological stage and tumor location. Increasing levels of CEA were found in advanced stages of the disease. There were no significant differences among the CEA levels of right-sided colon tumors, left-sided tumors and rectal tumors.

Adolescent↗

Gastric emptying in normal subjects and patients with peptic ulcer: a study using the acetaminophen method.

Gastric emptying in patients with peptic ulcer and normal subjects was studied using the acetaminophen method. The subjects consisted of 15 normal subjects, 52 gastric ulcer patients and 65 duodenal ulcer patients, who were studied in active stage of the ulcer. As an indicator of gastric emptying, the plasma acetaminophen concentration was measured by dye method (diphenylhydrazyl), as mcg/ml, at 45 minutes after ingestion of a high calory pasty test meal (200 ml) with 1.5 gr of acetaminophen. In normal subjects, the plasma acetaminophen concentration was 9.4 +/- 3.6 mcg/ml. In gastric ulcer patients, the concentration was 7.4 +/- 3.2 mcg/ml, which showed significantly delayed gastric emptying (P less than 0.05). In duodenal ulcer patients, the concentration was 11.6+/-3.3 mcg/ml, which suggested significantly rapid gastric emptying (P less than 0.05). In consideration of gastric secretion, gastric ulcer cases with lower acid secretion have more delayed gastric emptying. In duodenal ulcer cases with hypersecretion, gastric emptying is more rapid than normo-and/or hyposecretory cases (P less than 0.005). The delayed gastric emptying may play a role in etiology of gastric ulcer. On the other hand, the rapid gastric emptying with gastric acid hypersecretion may be important in the pathogenesis of duodenal ulcer.

Acetaminophen↗

Eosinophilic pustular folliculitis in association with nevoid basal cell carcinoma syndrome.

This study reports on the clinical and light microscopic features of a nevoid basal cell carcinoma syndrome with the complication of eosinophilic pustular folliculitis. To the authors' knowledge, this is the first report of such an association, which is possibly due to immune dysregulation. Moreover, the patient experienced remission of eosinophilic pustular folliculitis after removal of the jaw cyst. One possible explanation for the remission is that a long-lasting TH, type inflammatory response as a result of the bone defect produces effective cytokines such as interferon-gamma.

Adult↗