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Biomedical subjects

T Nishimura

Publications and source records attributed to T Nishimura.

At least 1,657 records · Page 92Linked to original sources
PubMed1977

[A case of medullary thyroid carcinoma with ectopic ACTH syndrome (author's transl)].

A 53-year-old male with Cushing's syndrome due to ectopic ACTH production from medullary carcinoma of the thyroid was reported. The clinical course and results of detailed endocrinological studies and immunohistochemical findings about the cancer tissue were described. An abnormally high concentration of calcitonin, ACTH and beta-MSH in both plasma and cancer tissue (thyroid, lymph nodes and liver) were documented by radioimmunoassay. Urinary 17-OHCS was as high as 38.4 mg/day and showed no supression following dexamethasone 8 mg/day administration. ORAL METYRAPONE (3 G/DAY) CAUSED NO RESPONSE IN URINARY 17-OHCS. Parallel increments in plasma calcitonin, ACTH and beta-MSH were observed following calcium and gastrin loading. Total thyroidectomy with modified radical neck dissection caused minimal changes of plasma levels of calcitonin, ACTH and beta-MSH and no improvement in the clinical manifestations of Cushing's syndrome. An aortogram revealed metastatic tumors in the liver. A second operation, total adrenalectomy, resulted in an improvement of the clinical and laboratory findings such as hypokalemia, high blood pressure, muscle atrophy and moon face. Immunofluorescent study showed different distribution patterns in calcitonin- and ACTH-positive cells in the primary focus but similar patterns in the liver metastasis.

Adrenalectomy↗
PubMed1977

Immunoglobulin A in split ejaculates of patients with prostatitis.

7S and 11S IgA (immunoglobulin A) levels in split ejaculates of 17 patients with chronic prostatis and 16 normal subjects were studied by the Hanson radial immunogel filtration method. The results suggest at least in certain cases of prostatitis increase of IgA level involves elevation of both types of IgA, and they are mainly of prostatic origin.

Body Fluids↗
PubMed1977

Clinical use of immunoelectrophoresis of split ejaculates. I. Variation of patterns due to antisera.

As a preliminary investigation for the clinical application of immunoelectrophoresis of ejaculate in the diagnosis of male reproductive organ diseases, variations of immunoelectrophoretic patterns in normal subjects due to the difference of antigenicity between split ejaculates were demonstrated with rabbit antisera. Fresh samples and antisera against them gave larger numbers of and more intense precipitin lines than in stored samples. The precipitin lines developed by acid phosphatase were most remarkable between first portion of ejaculate (F1) and anti-F1, whereas the line caused by protein from the seminal vesicle was most prominent between the remainder of the ejaculate following F1 (F2) and anti-F2.

Animals↗
PubMed1977

Evidence for androgen participation in induced ovulation in immature rats.

Rabbit antiserum to testosterone injected intravenously (iv) together with 10 IU human chorionic gonadotropin (hCG) markedly reduced the number of tubal ova in intact or hypophysectomized immature rats primed with 5 IU pregnant mare's serum gonadotropin. Normal rabbit serum (NRS) injected instead of the antiserum resulted in a normal complement of ovulated ova. Ten microgram of testosterone or 5alpha-dihydrotestosterone dissolved in NRS administered iv 1 h after simultaneous injection of hCG and antiserum to progesterone (anti-P) restored ovulation that would otherwise have been blocked by anti-P, with a comparable number of ova to control animals not given anti-P. The results indicate active participation of androgen in induced ovulation in immature rats.

Animals↗