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T Nishimura

Publications and source records attributed to T Nishimura.

At least 1,171 records · Page 65Linked to original sources
PubMed1987

Oxygen radical generation by polymorphonuclear leucocytes of beige mice.

Oxygen radical generation was measured using peritoneal exudate polymorphonuclear leucocytes (PMN) from a strain of beige mice, an animal model of the Chediak-Higashi syndrome. These PMN have been shown to exhibit delayed microbial killing and impaired phagosome-lysosome fusion. The amount of superoxide anion released by the PMN of the beige mice was similar to that released by the PMN of the control mice. The PMN of beige mice generated slightly less hydrogen peroxide than the control. Hydroxyl radical (.OH) generation and luminol-dependent chemiluminescence were significantly lowered in beige PMN stimulated with opsonized zymosan (OZ) or phorbol myristate acetate (PMA). Cytochalasin B-treated beige PMN showed a decreased ability to degranulate myeloperoxidase in response to OZ or PMA. We demonstrated the significant decrease in .OH generation and chemiluminescence in beige PMN, which might be one of the reasons to explain delayed microbial killing.

Animals↗
PubMed1987

Visualization of right atrial thrombus associated with constrictive pericarditis by indium-111 oxine platelet imaging.

A right atrial thrombus is not often seen and only a few reports of visualization have been described. We report a 44-yr-old man who had a large atrial thrombus associated with constrictive pericarditis. Two-dimensional echocardiography and computed tomography showed a large right atrial mass. Indium-111 oxine platelet deposition was demonstrated on the surface of thrombus by platelet imaging. Platelet imaging was useful for differential diagnosis from cardiac tumor, and as an indication for surgical treatment, since right atrial thrombus may have a high risk of pulmonary embolism or severe right heart failure.

Adult↗
PubMed1987

Characteristics of mouse thymocyte-derived, interleukin 2-activated killer cells and their precursors.

Culture of hydrocortisone (HC)-resistant C57BL/6 mouse thymocytes with recombinant human interleukin 2 (IL 2) allowed the proliferation of the thymocytes and resulted in the generation of lymphokine-activated killer (LAK) cells cytotoxic to a variety of tumor cells. The cytotoxic activity of the LAK cells was greatly reduced by treatment with anti-Thy 1.2 or anti-Lyt 2.2 monoclonal antibody and complement but not with anti-asialoGM1 antibody plus complement. Fractionation of IL 2-stimulated thymocytes by means of Percoll density gradient centrifugation revealed that both cytotoxic activity and binding capacity to target cells were greater in the cells with lower density and larger size than in the cells with higher density and smaller size. These IL 2-activated thymocytes expressed higher levels of both Thy 1, Lyt 2 and lymphokine-activated cell-associated (LAA) antigens than unstimulated thymocytes, as indicated by a flow cytometric analysis. The frequency of LAK precursor cells was found to be 7.5 times greater in the HC-resistant thymocyte population than in total thymocytes, as determined by means of a limiting dilution method. The LAK precursor cells in HC-resistant thymocytes appeared to be Lyt1- (or dull Lyt 1+), L3T4-, Lyt 2-, asialoGM1-T cells, because elimination of bright Lyt 1+, Lyt 2+ or L3T4+ T cells from HC-resistant thymocytes had no effect on the generation of LAK cells. These results indicate that LAK cells from mouse thymocytes are Lyt 2+ T cells which are inducible from HC-resistant Lyt 2- thymocytes.

Animals↗
PubMed1987

[A case of large diverticular stone of the anterior urethra].

A case of large diverticular stone of anterior urethra is reported. A 70-year-old man was admitted for dysuria, miction pain and hard mass beneath the scrotal skin. Retrograde urethrogram revealed a large stone in anterior urethral diverticulum and extravasation of contrast medium through the fistula from diverticulum. Open resection of diverticulum was performed and the stone was removed. Three months after the operation, the urethrogram showed no abnormal findings. The stone was 40 x 19 x 17 mm in size, weighed 16 g and was mainly composed of calcium phosphate.

Aged↗
PubMed1987

[Influences of percutaneous nephrolithotomy on renal function, an observation using the NAG-index and beta 2-microglobulin as indices].

To examine the influence of percutaneous nephrolithotomy (PNL) on renal function, we measured the activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) and beta 2-microglobulin (beta 2MG) in patients with nephrolithiasis, before and 3, 5, 7, 14 days and 1 month after PNL. With PNL, renal function was recovered within one month, and PNL was thought to be a more protective method than pyelolithotomy. Recovery of renal function was delayed in the cases in which PNL had been attempted over three times. In the patients with preoperative high-grade hydronephrosis, the excretion of NAG and beta 2MG in the urine was delayed. NAG-index was considered to be a more sensitive parameter than beta 2MG to evaluate renal function. The NAG-index and beta 2MG values of bladder urine were in good correlation with those of nephrostomy urine 5 days or more postoperatively. Measurement of the urinary NAG-index 3, 7, 14, 30 days after PNL operation was considered valuable for determining changes in renal function.

Acetylglucosaminidase↗
PubMed1987

[Myocardial perfusion detected using digital subtraction angiography as compared with X-ray CT and Tl-201 myocardial imaging].

Forty-two patients who underwent aorto-coronary bypass surgery were examined with intra-aortic digital subtraction angiography (IADSA) to detect abnormalities of myocardial blood perfusion. Tl-201 myocardial imaging and cardiac X-ray CT were performed nearly simultaneously about one month postoperatively. Cardiac imaging using IADSA was performed at a rate of 30 frames/sec with matrix size of 512 x 256. Time density curves of each pixel in the region of the myocardium of the left ventricle were post-processed to obtain functional images. The maximal concentration (Cmax), integration of the time-density curve (Cinteg), mean transit time (MTT), Cmax/MTT and Cinteg/MTT were computed for each pixel. Cmax and Cinteg are parameters related to the volume of the coronary vascular bed. Cmax/MTT and Cinteg/MTT are parameters related to the regional myocardial blood flow. These functional images showed hypoperfusion areas in 35 of 37 ischemic segments confirmed by wall motion in digital subtraction left ventriculography, Tl-201 myocardial imaging and ECG. Normal perfusion areas of the functional images were observed in 18 of 54 infarcted segments. These results show the complexities of myocardial perfusion in old myocardial infarction.

Coronary Angiography↗
PubMed1987

[Laboratory and clinical studies of flomoxef in the pediatric field].

We have carried out laboratory and clinical studies on flomoxef (FMOX, 6315-S). The results were summarized as follows. FMOX was given by 5-minute intravenous administration to 3 children at a single dose of 20 mg/kg. After the intravenous administration, mean serum levels of FMOX were 110.1 +/- 30.95 micrograms/ml at the end of injection, 44.4 +/- 10.55 micrograms/ml at 15 minutes, 11.0 +/- 1.72 micrograms/ml at 1 hour and 0.42 +/- 0.17 microgram/ml at 6 hours. The mean half-life was 1.14 +/- 0.30 hours. The mean urinary excretion rate was 68.8 +/- 17.4% up to 6 hours after the intravenous administration. FMOX was given by 30-minute drip infusion to 2 children at a single dose of 20 mg/kg and to 3 children at a single dose of 40 mg/kg. After the 30-minute drip infusion, mean peak serum levels of FMOX obtained for the 2 dose levels were 45.5 +/- 0.45 micrograms/ml and 87.4 +/- 18.35 micrograms/ml at the end of injection, respectively, and mean half-lives were 0.63 +/- 0.23 hours and 0.70 +/- 0.27 hours, respectively. The mean urinary excretion rate was 53.4 +/- 6.1% up to 6 hours after the 30-minute drip infusion of 40 mg/kg FMOX. Treatment with FMOX was made in 24 cases of pediatric bacterial infections; 5 cases of purulent tonsillitis, 2 cases of bronchopneumonia, 12 cases of pneumonia, and 1 case each of lymphadenitis, pyothorax, purulent meningitis, cellulitis, and abscess. Results obtained were excellent in 15 cases and good in 9 cases. No significant side effect due to the drug was observed in any cases.

Adolescent↗
PubMed1987

[Effects of cefotaxime on the coagulation system, especially their dependence on vitamin K-related factors].

The authors administered cefotaxime to 20 children and studied laboratory parameters concerning peripheral blood: hemoglobin count, blood platelet count, red blood cell count, and hematocrit value, and the coagulation system: protein induced by vitamin K deficiency or by the presence of a vitamin K antagonist II (PIVKA II), hepaplastin test (HPT), prothrombin time (PT) and active partial thromboplastin time (APTT). The results obtained are summarized as follows: 1. Peripheral blood No abnormal values were observed. 2. Coagulation system (1) PIVKA II: In all cases, PIVKA II was negative. (2) HPT, PT and APTT: In all cases, no significant changes of these values which would suggest the tendency for prolonged bleeding were observed.

Adolescent↗