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T Nishimura

Publications and source records attributed to T Nishimura.

At least 955 records · Page 53Linked to original sources
PubMed1990

[Correction of time resolution of an ambulatory cardiac monitor (VEST)--using a pulsate cardiac phantom].

Using ambulatory cardiac monitor (VEST) at exercise study, its time resolution is very important factor. We evaluated the time resolution of VEST using pulsate cardiac balloon phantom. Four analyses were carried out; no smoothing (NS) method, 3 points smoothing (3S) method, short sampling interval (SS) method, and digital filter (DF) method. By comparison of [delta EF[ ([EF: HR120-EF: HR60[) among 4 analysis methods, [delta EF[ by DF method was significant small. (NS: 3.58 +/- 3.01, 3S: 4.46 +/- 0.95, SS: 3.35 +/- 3.26, DF: 1.11 +/- 1.28%). We conclude that correction of time resolution by digital filter is necessary when we use VEST during exercise.

Ambulatory Care↗
PubMed1990

[Dye laser photocoagulation treatment for experimental subretinal neovascularization. 1. Histopathological findings of healing process].

To clarify the healing process of subretinal neovascularization (SRN) histopathologically following laser photocoagulation treatment, we performed laser photocoagulation for experimental SRNs produced in rhesus monkey eyes. To produce long-lasting SRNs, 0.5M 1-ornithine hydrochloride solution was injected intravitreously 2 weeks after photocoagulation. These SRNs were treated a 590nm dye laser, and examined clinically and histopathologically at 24 hours, 2 weeks, 3 months. Histopathologically, new vessels in the subretinal space were coagulated intensely and disappeared during the course of healed lesion. In these lesions, the retinal pigment epithelial cells proliferated in the subretinal space after the disappearance of the SRNs and covered the scar tissue. In strongly coagulated lesions, glial cells were related to the formation of scar tissue. These results showed that closure of new vessels was necessary for the healing of SRNs by photocoagulation and proliferation of the retinal pigment epithelial cells and glial cells occurred during their healing process.

Animals↗
PubMed1990

[Dye laser photocoagulation treatment for experimental subretinal neovascularization. 2. Histopathological findings of unsuccess lesions].

We observed the histopathological process in unhealed lesions following photocoagulation treatment for experimental subretinal neovascularization (SRN) in rhesus monkey eyes. Long-lasting SRNs were produced experimentally by the method which we previously reported. These SRNs were treated by a 590nm dye laser beam, and were examined clinically and histopathologically. Lesions in which insufficient photocoagulation treatment was performed showed serous fluid accumulation and fluorescein angiography revealed remaining neovascularization. In these lesions abundant patent neovascularization was seen with proliferation of spindle-shaped fibroblast-like retinal pigment epithelial (RPE) cells in the subretinal space. These metaplastic RPE cells produced matrix and abundant collagen fiber around the cells. The above results showed that insufficient photocoagulation induced neovascularization and proliferation of RPE cells in the subretinal space and promoted the formation of fibrovascular membrane.

Animals↗
PubMed1990

Streptococcal type-specific antibody in patients with glomerulonephritis (2): Correlation to their histological types.

Using the PHA method, streptococcal type-specific antibody was studied in sera from 230 patients with various types of nephritis diagnosed by renal biopsy in order to clarify the relationship between streptococcal infection and the histological types of glomerulonephritis. Two or more serologic types of streptococcal type-specific antibodies with high titers (1:384 or more) were significantly increased in patients with MGA, FGS, PGN, endocapillary proliferative GN, MPGN and IgA GN as compared with those in healthy subjects. Two or more serologic types having high titers (1:384 or more) were significantly increased in MGA, PGN, MPGN and IgA GN as compared with MN. The highest titers (1:768 or more) of streptococcal type-specific antibodies were significantly more frequent in endocapillary proliferative GN as compared with healthy subjects, and such titers were significantly increased in endocapillary proliferative GN and MPGN as compared with MN. The frequency of detection of streptococcal serologic types having high titers (1:384 or more) as found in patients with various nephritis, was in the order of Types 18, 3, 30, 1, 12, 10, 6 and 37, and more than half of the nephritogenic types were included in these serologic types. The above data, which suggest a higher probability of contact with nephritogenic strains during alternative establishment of streptococci by different serologic types, may indicate a close relationship of streptococcal infections with MGA, PGN, MPGN, IgA GN, FGS and endocapillary proliferative GN.

Adolescent↗
PubMed1990

[Effect of specific desensitization therapy in combination with an immunopotentiator, Neurotropin, on perennial nasal allergy--with special reference to mite specific IgG and IgG4 antibody levels].

We treated perennial nasal allergy with specific desensitization in combination with or without Neurotropin injections (NSP) from March 1983 to September 1984, and analyzed blood anti-mite IgG and IgG4 levels in relation to therapeutic efficacy. Desensitization and NSP were given once a week and seventy subjects (33 from the desensitization group and 37 from the desensitization + NSP group) were evaluated at 24, 36 and 48 weeks. 1) In total cases clinical usefulness showed no significant difference between the desensitization group and combined group at 24 weeks, while in "useful or more" cases significantly better results were attained in the latter at 24 weeks and 48 weeks (p less than 0.05, respectively). 2) Dermatophagoides pteronyssinus (D.p.) specific IgG antibody showed no significant difference between both groups as well as in each group during the overall examination period. 3) In total cases both D.p. specific and D. farinae (D.f.) specific IgG4 were significantly higher in the combined group at 24 and 36 weeks (D.p.: p less than 0.01 and D.f.: p less than 0.05, respectively), whereas in "useful or more" cases only D.p. specific IgG4 showed a significant elevation in the combined group at 24 weeks (p less than 0.05). These results suggest that specific desensitization in combination with NSP can promote early production of mite specific IgG4, which tend to rise in correlation with clinical efficacy.

Adjuvants, Immunologic↗
PubMed1990

[Laboratory and clinical studies of cefodizime in pediatric field].

We have carried our laboratory and clinical studies on cefodizime (CDZM, THR-221). The results were summarized as follows. CDZM was given by 30-minute drip infusion to 2 children at a single dose of 10 mg/kg and to 2 children at a single dose of 20 mg/kg and to 3 children at a single dose of 40 mg/kg. After the 30-minute drip infusion, mean serum levels of CDZM obtained for the 3 dose levels were 76.16 +/- 5.52 micrograms/ml, 170.49 +/- 16.70 micrograms/ml, 270.01 +/- 50.44 micrograms/ml at the end of injection, respectively, and serum half-lives were 2.03 +/- 0.78 hours, 2.03 +/- 0.38 hours, 2.28 +/- 0.30 hours, respectively. The mean urinary excretion rate of CDZM were 83.3 +/- 22.3%, 73.1 +/- 13.9%, 51.1 +/- 8.5% in the first 8 hours after the 30-minute drip infusion of 10 mg/kg, 20 mg/kg, 40 mg/kg, 40 mg/kg, respectively. Treatment with CDZM was made in 28 cases of pediatric bacterial infections; 5 cases of tonsillitis, 2 cases of bronchitis, 10 cases of pneumonia, 6 cases of enteritis, 3 cases of urinary tract infection and 1 case each of maxillary sinusitis and laryngitis. Results obtained were excellent in 13 cases, good in 7 cases, fair in 2 cases, poor in 6 cases. No significant side effect due to the drug was observed except one case of thrombocytosis and 2 cases each of elevated GOT and elevated GOT and GPT.

Absorption↗
PubMed1990

Prediction of central apnea episodes in infants during sleep.

This study describes a prediction method for central apnea episodes of newborns during sleep. The cross-correlation between heart rate and respiration obtained from newborns is calculated. Employing the cross-correlation, the displacement between heart rate and respiration before central sleep apnea episodes was much larger than the displacement in the stationary state. As the result, it is possible to predict central sleep apnea episodes several minutes before their occurrence.

Algorithms↗
PubMed1990

Exercise-induced ST-segment elevation in leads over infarcted area and residual myocardial ischemia in patients with previous myocardial infarction.

The purpose of this study was to evaluate the clinical significance of exercise-induced ST elevation in patients who had previous myocardial infarction. Electrocardiographic leads were placed over the infarcted area in 65 patients who had previous myocardial infarction (PMI; isolated left anterior descending coronary artery disease). All patients also had stress thallium scan. Exercise-induced ST changes in leads placed over patients' infarcted areas were compared with the extent of both their myocardial ischemia [thallium ischemic score (TIS)] and the area of their infarcted tissue [defect score (DS)]. The latter was derived from a circumferential profile analysis. In patients who had PMI less than three months after the onset of myocardial infarction (n = 36), the left ventricular ejection fraction (LVEF) and the extent of abnormal left ventricular wall motion did not significantly differ from those in patients with exercise-induced ST elevation (greater than 2 mm, n = 26; less than 2 mm, n = 10). In patients who had PMI more than three months after the onset of myocardial infarction (n = 29), patients with high exercise-induced ST elevation (greater than 2 mm, n = 15) showed left ventricular dyskinesis more frequently than those with low ST elevations (less than 2 mm, n = 14). In addition, the former showed higher DS and lower TIS than the latter. In patients who had PMI less than three months after onset (n = 26), 73% of those with ST elevations with prominent upright T waves (n = 15) also had transient thallium defects in their infarcted areas. They also had higher LVEF and TIS than those with low ST elevations (less than 2 mm, n = 11). These results indicated that exercise-induced ST elevations in leads placed over the infarcted areas are to be interpreted differently depending on the degree of recovery of injured myocardial tissue.(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Circulation↗
PubMed1990

[111In-antimyosin Fab scintigraphy in cardiovascular diseases: (multicenter clinical trial)].

In a multicenter study, a total of 380 patients with myocardial infarction, myocarditis and cardiomyopathy underwent 111In-Antimyosin Fab myocardial imaging. 111In-Antimyosin Fab was administered intravenously and myocardial images were obtained 48 hours later. Only 3 patients developed mild adverse effects. Human antimouse antibodies were detected in 7 patients. Positive scans in patients with myocardial infarction were seen in 92/119 (77%) within 2 weeks after the onset of myocardial infarction, in 58/71 (82%) at 3-4 weeks, in 20/22 (91%) at 4-8 weeks and 17/31 (55%) thereafter. The location of myocardial damage delineated by 111In-Antimyosin Fab imaging was concordant with the infarct location by ECG and coronary angiography. In patients with myocarditis, 111In-Antimyosin Fab uptake was positive in 7/12 (58%) within 8 weeks and 6/17 (35%) thereafter. Positive 111In-Antimyosin Fab scans were seen in 12/36 (33%) in dilated cardiomyopathy and in 17/19 (89%) in hypertrophic cardiomyopathy. Although the mechanism of persistently positive 111In-Antimyosin Fab images in the subacute to chronic stage of myocardial infarction and myocarditis remains to be clarified, 111In-Antimyosin Fab may be useful for the detection of the diseases and in evaluating the prognosis of patients with cardiomyopathy.

Adult↗
PubMed1990

[Accumulation of 111In-antimyosin antibody at the focal site of inflammation].

An p6-year-old man with anterior acute myocardial infarction was administered antimyosin antibody labeled with 74 MBq (2 mCi) 111In, and abnormal hot activity was observed in the left lung by immunoscintigraphy. 67Ga-citrate scintigraphy also showed abnormal uptake in this lesion. At this time, this patient complained of fever and cough with sputum, and roentgenography showed a coin lesion-like shadow at the same location of the lung. By treatment with antibiotics, his symptom was improved and coin lesion-like shadow disappeared. So we thought the RI uptake area in the left lung was inflammatory lesion. This case suggests that 111In-antimyosin antibody can be trapped to the focal site of inflammation.

Aged↗
PubMed1990

[Clinical variables that can cause the underestimation of the viable myocardium in the infarcted area: results of the sequential exercise thallium-201 myocardial scintigraphy].

Clinical variables that can cause the underestimation of the viable myocardium were examined in the sequential exercise thallium-201 study before and after PTCA. Among 60 patients who had documented myocardial infarction with single coronary artery disease, 43 patients had successful PTCA. Compared to the initial images after PTCA, the 4 hour-delayed images before PTCA had larger and more severe defect in the infarcted area of 14 patients (33%). This underestimated group had shorter period from the infarction to the stress study. (3.4 +/- 2.4 M vs. 7.1 +/- 9.2 M; p less than 0.05), and attained more maximal heart rate during the stress study. The numbers of the patients who had severe stenosis (greater than or equal to 99%) were more in the underestimated group (79% vs. 34%; p less than 0.01). The patients who have recent myocardial infarction, especially within three months, are likely to be underestimated their viable myocardium in the infarcted area, and this variable is dependent from their workload during the stress study and the severity of the stenotic lesion which also affect the estimation of the myocardial viability.

Angioplasty, Balloon, Coronary↗
PubMed1990

[Metastatic tumors of the gingiva--report of 3 cases].

Metastatic tumors to the oral region are uncommon and most are located in the mandible, with only a few in the soft tissue of the oral cavity. A review of the literature has revealed only 63 cases of a gingival soft tissue metastases. The prevalent primary site are the lung, the liver and the kidney in that decreasing order. Reported are two lung carcinomas and an esophageal carcinoma all showing a metastases to the gingival soft tissue. The primary lesions of two lung carcinomas were diagnosed after the detection of the gingival lesions. In all cases the diseases had disseminated when the gingival metastases were diagnosed. The longest survival time was only 4 months. The prognosis for such cases is poor, but early diagnosis and treatment is essential in order to prevent the pain and discomfort associated with the ulceration, the infection, and the local tissue destruction by the lesions.

Adenocarcinoma↗
PubMed1990

[A case of bilateral interhemispheric subdural hematoma].

Interhemispheric subdural hematoma (ISDH), although not infrequent in children, has been rarely encountered in adults. Spread of CT, ISDH has been reported sporadically, and so far more than 40 cases have been reported. But bilateral ISDH is an extremely rare lesion, with only 5 cases reported in the literature. We report a sixth case of bilateral ISDH in adults. A 68-year-old woman was admitted because of headache and vomiting. Two days before admission she had fallen, striking her occiput, and had lost consciousness for a few minutes. Neurological examination on admission revealed hyperreflexia of her extremities, especially in her left leg. However, motor weakness was not recognized. There was no fracture visible on the plain X ray films of the skull. Axial CT scan demonstrated a high density lesion along the falx and its extension down over the tentorium. Coronal CT scan also demonstrated a convexo-convex high density lesion beside the falx, and its extension onto the tentorium. Cerebral angiogram showed lateral displacement of the callosomarginal artery, and an avascular area beside the falx and onto the tentorium. After admission she was managed conservatively, but on the 14th day after head trauma, paraparesis and left arm paresis were recognized. This condition deteriorated and she developed an inability to stand. On the 19th day parasagittal craniotomy and evacuation of the hematoma were performed. Her postoperative course was uneventful and she was discharged with no neurological deficits.

Aged↗
PubMed1990

[Pharmacokinetic and clinical studies on aztreonam in neonates].

Pharmacokinetic and clinical studies on aztreonam (AZT) in mature and premature neonates were carried out. The results are summarized as follows. The mean serum peak level of AZT after intravenous administration at a single dose of 20 mg/kg in 3 to 4 day-old-neonates was 36.6 +/- 2.39 micrograms/ml at 1 hour after dosage. The mean serum level at 6 hours after dosage was 13.5 +/- 2.03 micrograms/ml. The mean half-life time was 3.86 +/- 0.92 hours. The mean urinary excretion rate was 25.1 +/- 5.18% in the first 6 hours after intravenous administration. AZT was administered in 4 cases, but the effects could not be evaluated. No side effect was observed except an elevation of GOT.

Ampicillin↗
PubMed1990

[Follow-up pulmonary perfusion scintigraphy pulmonary arterial embolization in two cases of familial pulmonary arteriovenous fistula].

Follow-up pulmonary perfusion scintigraphy in evaluating pulmonary arterial embolization were assessed by two cases of pulmonary familial arteriovenous fistula. Pulmonary arteriovenous fistula was found for brain abscess in the older brother, and for dyspnea on effort in the younger brother. Pulmonary arterial embolizations were performed. (older brother: 4 times, younger brother: 5 times) Before embolization, pulmonary perfusion scintigram showed pale defect, clear asymmetric perfusion between right and left lung, and clear renal visualization. On the other hand, after the embolization, clear multiple defects agreed with the sites of embolization, and asymmetric pulmonary perfusion and renal visualization disappeared. We conclude that follow-up pulmonary perfusion scintigraphy is useful to evaluate in pulmonary arteriovenous fistula after embolization.

Adolescent↗