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Biomedical subjects

T Niimi

Publications and source records attributed to T Niimi.

At least 109 records · Page 6Linked to original sources
PubMed1990

[Effect and prognosis of rehabilitation for cerebrovascular dementia in the elderly].

The effect of rehabilitation and prognosis for elderly cases of cerebrovascular dementia were evaluated by comparing the group of the patients receiving rehabilitation with those who did not receive rehabilitation. There were no significant differences in the age, neurological symptoms, psychotic symptoms, physical complications, ADL and Hasegawa's dementia rating scale between the two groups. The main reason for rehabilitation was recurrence of cerebrovascular attack (42.9%), disuse atrophy (42.9%) and bone fracture and others (14.3%). There was significant improvement of ADL in the patients showing a score of more than 10 on Hasegawa's dementia rating scale and in the patients given drugs to improve cerebral circulation and metabolism, but there was no significant improvement of Hasegawa's dementia rating scale. Concerning the prognosis of patients receiving the rehabilitation, there was no change of ADL and Hasegawa's dementia rating scale. In the group of patients which did not receive rehabilitation, significant decrease of ADL was noted, but there was no change of Hasegawa's dementia rating scale.

Activities of Daily Living↗
PubMed1990

Recognition of tRNA identity determinants by aminoacyl-tRNA synthetases.

By analyzing aminoacylation activities of variants of isoleucine tRNAs and glutamic acid tRNA from Escherichia coli, it was found that the anticodons are the major determinants for "identities" of these tRNAs. It was also shown that the post-transcriptional modifications are essential to aminoacylation of these tRNAs. Interactions between the tRNAs and the aminoacyl-tRNA synthetases were analyzed by NMR spectroscopy.

Amino Acyl-tRNA Synthetases↗
PubMed1990

[A case report of endobronchial lipoma].

Endobronchial lipomas are rare benign tumors of the lung. Nineteen cases have been reported in Japan. We present a case of endobronchial lipoma obstructing the left B4b and chronic saccular bronchiectasis throughout the left upper lobe. A 42-year-old man, 174 cm tall and weighing 47 kg, was referred for investigation of an abnormal chest X-ray film. He had a history of pneumonia and pyothorax in infancy. The chest X-ray film showed linear densities and ill-defined, irregular opacities in the upper-middle lung field. CT scan and tomographic studies showed multiple cystic spaces in the left upper lobe in which the volume was diminished. An angiogram of the left bronchial artery showed peripheral hypervascularity in the left upper lobe and systemic-to-pulmonary artery shunt. Fiberoptic bronchoscopy revealed a smooth, pink mass obstructing B4b. Biopsy specimens were insufficient for histological diagnosis. Preoperatively, an inflammatory polyp in association with chronic saccular bronchiectasis was suspected. Left upper lobectomy was performed on January 13, 1989. Gross examination of the resected specimen showed a pedunculated polypoid mass, 1.5 X 1.2 X 0.6 cm, attached to the bronchial mucosa of B4bii and saccular ectatic changes of bronchi not only in the lingular division but also in upper division. Microscopically, the endobronchial tumor consisted of mature adipose tissue covered with columnar bronchial epithelium. The fat was fairly well localized in the submucosa, but was not encapsulated and did not enclose glands or smooth muscle fibers. The endobronchial lipoma was thought to originate in the bronchus of chronic saccular bronchiectasis.

Adult↗
PubMed1989

A case of primary intrapulmonary neurilemoma and review of the literature.

In this paper, we present an extremely rare case of a primary intrapulmonary neurogenic tumor, in which localization of S-100 protein, neuron specific gamma-enolase (NSE) and CEA was investigated using immunohistochemical staining. The patient, who was a 39-year-old man, experienced no symptoms; however, a routine chest X-ray revealed a round tumor-like shadow in the infrahilar area of the right lung. As the tumor appeared to be gradually increasing in size, surgery was performed and histopathological examination of the excised tumor revealed it to be a primary intrapulmonary neurilemoma. Immunohistochemical staining demonstrated the presence of S-100 protein in the tumor cells but NSE and CEA were not detected. For the 2 years following his operation, the patient has been in good health and is now under careful observation.

Adult↗
PubMed1989

[An autopsy case of pallido-nigro-luysian atrophy associated with OPLL].

Clinical and neuropathological studies of a case of pallido-nigro-luysian atrophy with thalamic degeneration and ossification of the posterior longitudinal ligament (OPLL) is reported. The patient was a 72-year-old man, suffering from gait disturbance caused by OPLL for about 3 years. The clinical features were characterized by gradual development of disorientation in place, time and person, memory disturbance, vertical gaze palsy and rigidity of extremities. Dysarthria, dysphagia, bradykinesia, masked face and neck dystonia appeared at the advanced stage of his illness. There was no tremor or other involuntary movements. A clinical diagnosis of parkinsonism was suspected. The main neuropathological findings were neuronal loss and gliosis in globus pallidus, substantia nigra, subthalamic nucleus and thalamus. In addition, neuronal loss of the anterior horn of the cervical spinal cord due to compression by OPLL (C4-C7) was recognized. The neuropathological findings of the present case were consistent with systemic degenerative disorder of the nervous system affecting the pallido-nigro-luysian tract. This rare disorder should be considered in the differential diagnosis of parkinsonism in old people.

Aged↗
PubMed1989

[A clinicopathological analysis of cardiac rupture following acute myocardial infarction in elderly patients].

In all autopsied cases from January 1980 to June 1988 (56-102 years old, 243 men and 307 women), cardiac rupture death was observed in 14 cases out of 68 deaths of acute myocardial infarction in our hospital. Cardiac rupture occurred in 2, 4, 3, and 5 cases in their 60's, 70's, 80's, and 90' respectively, and 4 in men and 10 in women. Complaints of chest pain were present in 4 cases. Cerebrovascular disease was present in 9 cases and hypertension in 7. In 9 cases, the thickness of the ruptured wall was over 14 mm. The location of the ruptured lesion was the anterior wall in 4 cases, anteroseptal in 3, anterolateral in 1, lateral in 1, posterior in 1, and apical in 1. In conclusion, the incidence of cardiac rupture was higher in female than in males, and in silent myocardial infarction than in painful one. The location of rupture was frequently in the anterior or lateral wall. Aging and hypertension would not be a worsening factor in the pathogenesis of cardiac rupture in myocardial infarction, but cerebrovascular disease might be a risk factor in respect to masking occurrence of myocardial infarction.

Aged↗
PubMed1989

[Development of Alzheimer neurofibrillary changes in two autopsy cases of myotonic dystrophy].

Histopathological examination of two autopsy cases of myotonic dystrophy (MyD), a 65-year-old man (case 1) and a 61-year-old woman (case 2), revealed Alzheimer's neurofibrillary tangle (NFT) in the limbic system without concomitant presence of senile plaque as well as cavum septi pellucidi and thalamic inclusion body. The NFT were particularly abundant in the mesolimbic cortex. In addition to these, small traumatic scars were observed in the frontal lobe of case 1, who had clinically shown severe dementia. From these findings, it might be assumed that both premature aging and head trauma played an important role in the pathogenesis of NFT in these patients with MyD. The dementia of case 1 could be correlated well with abundance of NFT in the mesolimbic cortex.

Aged↗
PubMed1989

[A case of benign mesenchymoma of the chest wall recurred 8 years after the last operation].

Benign Mesenchymoma of the chest wall is very rare neoplasm. We report a case of the tumor. The patient is a 64 year-old male, whose tumor was removed on 1978. Histologically, the tumor was diagnosed as benign mesenchymoma. However, 8 years after the last operation, the tumor recurred in the right chest wall. The tumor was 4.5 X 4.0 cm in size and was removed smoothly n Nov. 1986. It was composed of fat tissue, blood vessels and smooth muscles. One year and two months later, the patient is alive without recurrence.

Humans↗
PubMed1988

[Clinical study on transfer into lung tissue and postoperative prophylactic effect of new cephamycin antibiotics, particularly cefotetan and cefbuperazone].

The following findings were obtained in our clinical study on the transfer of cefotetan (CTT) and cefbuperazone (CBPZ), new antibiotics of cephamycin series, into the lung tissue and on their postoperative prophylactic effect. 1. The mean serum concentration 30 minutes after the start of an intravenous drip infusion of 1 g of CTT over a period of 30 minutes was 99.4 micrograms/ml, and it decreased gradually thereafter with the half-life of 2.45 hours. After an intravenous drip infusion of 1 g of CTT over a period of 1 hour, the mean peak concentration of 104.1 micrograms/ml appeared 1 hour after the start of the infusion, and mean concentrations at 2, 4 and 6 hours after the infusion were 63.4, 34.3 and 27.0 micrograms/ml, respectively, with the half-life of 2.35 hours during phase beta. 2. Following 30 minutes of an intravenous drip infusion of CTT, the tissue CTT level in normal lung tissues was Tmax 1.82 hours and Cmax 19.8 micrograms/g. After 1 hour of an intravenous drip infusion the mean concentration in the tissues was at the peak of 39.7 micrograms/g in 2 hours after the start of an administration, while mean levels at 3, 4 and 6 hours after an administration were 32.2, 22.2 and 8.76 micrograms/g, respectively, with Tmax of 1.82 hours and Cmax of 30.5 micrograms/g. 3. Following an intravenous drip infusion of 1 g of CBPZ over a period of 1 hour, the mean serum drug concentration 1 hour after the start of infusion was at its peak, 83.3 micrograms/ml, while mean values at 2, 4 and 6 hours after the start of an administration were, respectively, 40.4, 19.8 and 9.62 micrograms/ml, with the beta-phase half-life of 2.03 hours. 4. By 1 hour after the start of intravenous drip infusion of CBPZ, the mean tissue level in normal lung tissues was at the peak of 31.6 micrograms/g, while mean levels at 3, 4 and 8 hours after an administration were 16.2, 11.0 and 4.56 micrograms/g, respectively, with Tmax of 1.67 hours and Cmax of 21.9 micrograms/g. 5. Infused CBPZ was transferred into bronchiole tissues. Drug concentrations in these tissues at 3 and 5 hours after the start of the infusion were 7.87 and 4.85 micrograms/g, respectively, with their ratios to the peak serum level were 9.4 and 5.8%, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1988

[A clinical trial of astromicin, a new aminoglycoside antibiotic, in thoracotomized patients and astromicin concentrations in the lung tissue].

There have been no report on concentrations in human lung tissue of aminoglycoside antibiotics which are frequently used in combination with cephem antibiotics in the treatment of severe respiratory infections. The authors examined lung tissue concentration of astromicin (ASTM) during clinical trials in thoracotomized patients using intravenous drip infusion just before operation. And the following conclusions have been obtained: 1. The average peak serum level obtained upon intravenous drip infusion of ASTM 200 mg for 1 hour just before operation was 11.2 micrograms/ml at 1 hour after starting the administration and half-life of ASTM in beta phase was 2.90 hours. 2. ASTM concentrations in the lung tissue upon 1 hour intravenous drip infusion just before operation at a dose level of 200 mg reached a maximum at 2 hours after the start of the administration averaging 7.7 micrograms/ml and were 27.7-68.8% of serum peak level. 3. Bronchiolar concentrations of ASTM 200 mg upon 1 hour intravenous drip infusion just before operation were 33.0-72.3% of peak serum level. These concentrations appear to be sufficient for the treatment of target infections. 4. The 1 hour intravenous drip infusion of ASTM 200 mg appeared to be clinically safety and useful as was the intramuscular injection of ASTM 200 mg.

Adolescent↗
PubMed1987

Immunohistochemical characteristics of proliferative and metaplastic lesions in bronchial mucosa.

To elucidate the characteristics of metaplastic changes of bronchial mucosa, the distribution of four epithelial antigens and two subtypes of enolases was studied immunohistochemically. The authors classified the metaplastic changes into three types: basal cell hyperplasia, stratification, and squamous metaplasia. Secretory component (SC) was detected in all lesions with stratification and in three of ten lesions of squamous metaplasia. Epithelial membrane antigen (EMA) was localized not only on the luminal surfaces but also among the stratified layers of metaplastic epithelium. No carcinoembryonic antigen (CEA) was detectable in normal epithelium, whereas almost all metaplastic lesions had both nonspecific cross-reacting antigen (NCA) and CEA immunoreactivity. In normal mucosa, basal cells were strongly positive for alpha-enolase but negative for gamma-enolase, and columnar cells expressed both enolases. In areas of metaplasia, alpha-enolase was present throughout the layer, but gamma-enolase was absent. These immunohistochemical findings suggest that metaplastic squamous epithelial cells have glandular differentiation and that several biochemical and metabolic aberrations occur during the process of metaplasia.

Antigens, Surface↗
PubMed1987

[Clinical study of cefmenoxime in thoracic surgery. Transfer of cefmenoxime to lung tissue and pleural fluid and prophylaxis of postoperative infections].

Twenty-six patients who underwent pulmonary resection for the lung disease were administered 1 g of cefmenoxime (CMX) by intravenous drip infusion just before the operation. The CMX levels in the serum, lung tissue and pleural fluid were measured using the agar-well technique. The effect of the drug on the prophylaxis of postoperative infections was investigated. The obtained results are summarized as follows; 1. The peak concentration of CMX in the serum was 58.23 micrograms/ml 1 hour after starting the drip infusion of 1 g of CMX. The serum half-life of CMX (beta-phase) was 2.15 hours. 2. The ratio of the CMX concentration in lung tissue to the peak serum level was 14.9% 202 minutes after starting the drip infusion. In the pulmonary lesion, the ratio was 9.72% at the 201 minutes. In the bronchiole, the ratio was 20.7% 191 minutes after starting the drip infusion. 3. The concentration of CMX in the pleural fluid was 2.53 micrograms/ml 12 hours after starting the drip infusion. 4. CMX is useful as a prophylaxis of postoperative infections after thoracotomy, because no postoperative infectious complications were observed.

Adult↗