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Biomedical subjects

T Naruke

Publications and source records attributed to T Naruke.

At least 109 records · Page 6Linked to original sources
PubMed1985

[Adjuvant chemotherapy for lung cancer].

After analysing 1929 cases of resection for lung cancer under the classification of adjuvant therapy, histology, stage and chronology, we learned positive points of adjuvant chemotherapy and its problems. The five year survival rate of 45 cases of small cell carcinoma is 23.9% (oat cell 18.5%, intermediate 28.6%). Long-term survivors are always found among the stage I patients, however, better results (14.7%-60.6%) have been shown since 1980. This fact must be derived from recent achievements of chemotherapy. Seven cases of adjuvant surgery for small cell carcinoma shows needs of chemotherapy. The randomized controlled study by using vindesine for non-small cell carcinoma, stage III, and also other studies showed no signs of effectiveness of chemotherapy on non-small cell carcinoma. Clinical application of clonogenic cell assay has made an advance in selecting types of chemotherapy. The problems are, however, administration of drugs, i.e. selection of drugs, time and period to administrated, accurate diagnoses and precise judgement of clinical stage and drug tolerance of patients. We expect more effective drugs to come in the near future.

Adult↗
PubMed1984

Six cases of well-differentiated adenocarcinoma simulating fetal lung tubules in pseudoglandular stage. Comparison with pulmonary blastoma.

Six cases of well-differentiated adenocarcinoma resembling fetal lung were studied histologically, immunohistochemically, and ultrastructurally, and compared with three cases of pulmonary blastoma. The six cases had no sarcomatous features, unlike the pulmonary blastoma. Individual tumor cells characteristically possessed clear cytoplasm with plentiful glycogen and were similar to the epithelial cells of the branching tubules in the pseudoglandular stage of the fetal lung, as well as the epithelial component of pulmonary blastoma. They also showed little differentiation toward mucous cells and ciliated cells. Although cells containing endocrine-type granules were not found ultrastructurally, a few tumor cells possessed the characteristics of endocrine cells, i.e., cytoplasm was immunohistochemically reactive with anticalcitonin and antigastrin-releasing peptide. Therefore, this type of adenocarcinoma is considered to have a histogenesis similar to that of pulmonary blastoma and may be a tumor with one-sided development of pulmonary blastoma showing only an epithelial component.

Adenocarcinoma↗
PubMed1984

[Problems and future directions for early detection of lung cancer].

Mass screening methods for lung cancer consist of X-ray examination in men and women over 40 years of age and X-ray examination plus sputum cytology test confined to high risk groups. Examination methods which seem to be most effective for early detection at present are introduced based on the results of the examinations and treatment provided. If we are to conduct this method extensively in the future there remain many problems unsolved yet: how to systematize the execution, to contact with more examinees, to increase examination capability and effectiveness etc. Our recent directions for the nation-wide mass screening of lung cancer consist of four methods: 1. Utilization of local self-governmental mass screening. 2. Mass screening conducted by general practitioners at local clinics. 3. Active cooperation of general practitioners with local self-government. 4. Public participation in the lung project. We should continue our efforts to solve these problems.

Adult↗
PubMed1983

Bronchoplastic surgery for lung cancer and the results.

Fifty-nine patients with lung cancer underwent bronchoplastic surgery in our institute from September, 1965 to May, 1982. The post surgical stages of disease were as follows: 7 cases of Stage I disease, 7 cases of Stage II, 41 cases of Stage III, 4 cases of Stage IV. The bronchoplastic surgery performed included sleeve resection combined with lobectomy in 35, wedge resection combined with lobectomy in 11, reconstruction of the lower area of the trachea in 5, bronchial sleeve resection combined with pulmonary artery resection in 6 and bronchial wedge resection combined with pulmonary artery resection in 2. There was no case of operative mortality within 30 days after the operation. To prevent postoperative complications, careful techniques are required in suturing and postoperative bronchoscopic suction of intrabronchial secretion is necessary. The use of Dexon or Dexon S, polyglycolic acid sutures, showed good results. Adjuvant therapies were performed on 42 cases, including preoperative infusion of Mitomycin C into the bronchial arteries or postoperative irradiation or both. Twenty-eight of 59 were alive and well from 7 months to 16 years after the operations. The relative 5 year survival rates were 40.5 per cent in total cases and 46.5 per cent in those with squamous cell carcinomas. The prognosis of patients undergoing bronchoplasty was compared with that of patients undergoing lobectomy and pneumonectomy. There was a statistical difference between bronchoplasty and pneumonectomy.

Adenocarcinoma↗
PubMed1983

[Efforts for early detection of lung cancer].

The 3rd survey of "The Lung Cancer Early Detection Project" inaugurated in 1972, was conducted by Naruke team during the period from 1978 to 1980 on 1, 632, 157 test subjects collected from 60 institutions throughout Japan. Cases of detected lung cancer were classified in two groups as Prevalence case and Incidence case and discussed in the report. As the result, X-ray examination was effective to detect early peripheral lung cancer, and for high risk group X-ray examination combined with sputum cytology test indicated the highest detection rate for early hilar lung cancer. Our recent directions for the nation-wide mass screening of lung cancer consist of four methods: 1. Utilization of local self-governmental mass screening. 2. Mass screening conducted by general practitioners at local clinics. 3. Active cooperation of general practitioners with local self-government. 4. Public participation in the Lung Project. We should continue our efforts to solve these problems.

Adult↗
PubMed1983

[Immunomorphologic responses of regional lymph nodes and prognosis in patients with stage Ia pulmonary adenocarcinoma].

The relationship between postoperative prognosis and the immunomorphologic response of regional lymph nodes was examined in 50 patients with stage Ia peripheral bronchial adenocarcinoma and compared with 22 patients in stage Ib and II. Regarding paracortical lymphocyte hyperplasia, the prognosis of the responsive group in patients with stage Ia was significantly better than that of the non-responsive group; however, no definite relationship was found between follicular hyperplasia and prognosis. Follicular hyperplasia correlated with the size of the primary lesion or the distance from the site of the primary lesion. In stage Ib and II cases with metastasis to the pulmonary hilar lymph nodes, paracortical lymphocyte hyperplasia or follicular hyperplasia had no relation to the postoperative prognosis.

Adenocarcinoma↗