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Biomedical subjects

T Naito

Publications and source records attributed to T Naito.

At least 343 records · Page 19Linked to original sources
PubMed1976

A necropsy case of interstitial nephritis probably related to cefazolin and methenamine.

It is the purpose of this paper to alert the medical community on the potential nephrotoxicity of certain agents among certain patients, especially with some types of renal insufficiency. A young man, who was suffering from apparent renal disturbance, died of massive, post-operative bleeding accompanied by uremia. The uremia occurred within a very rapid clinical course and was related apparently to treatment with methenamine, a ruinary disinfectant, and cefazolin, a cephalosporin derivative. The patient was proved to have a fatal, servere interstitial nephritis based on gross and histological findings of the necropsied kidney, i.e., intense cell infiltration mainly in the interstitum of the cortex, absence of glomerular involvement, and marked softening and enlargement. The present case may suggest how to treat patients suffering from untoward renal ailments with various antibiotics.

Adult↗
PubMed1975

Acetylation of amikacin, a new semisynthetic antibiotic, by Pseudomonas aeruginosa carrying an R factor.

A clinical isolate Pseudomonas aeruginosa GN315 resistant to amikacin (AK), a new semisynthetic antibiotic, inactivated AK by acetylation. The acetylating enzyme was purified approximately 146-fold from a crude extract of GN315 by affinity chromatography. Fractionated samples obtained by affinity chromatography showed almost the same inactivation curves toward 3',4'-dideoxykanamycin B (DKB) and AK. Partially purified AK-acetylating enzyme inactivated DKB and kanamycin A but could not inactivate gentamicin C(1). The optimal pH for their inactivation was 6.0 to 7.0, and the pH curves for the inactivation of both drugs were almost the same. These facts indicate that AK and DKB are inactivated by the same aminoglycoside-acetylating enzyme. Through elemental analysis, the inactivated AK was found to be a monoacetylated product of AK. A sample of inactivated AK was purified and compared with a synthetic 6'-N-acetyl AK by thin-layer chromatography, and the results indicated that AK was inactivated by acetylation of the 6'-NH(2) group. The ultraviolet, infrared, and nuclear magnetic resonance spectra of the inactivated AK showed that AK was inactivated by the enzyme through acetylation of the amino group of 6'-amino-6'-deoxy-d-glucose moiety of AK. This enzyme, mediated by R factor, is capable of conferring resistance to AK, DKB, kanamycin, gentamicin, and sulfanilamide.

Aminoglycosides↗
PubMed1975

[Observations on the gastrointestinal movements of the tortoise (Geoclemys reevesii) by means of the abdominal-window-technique].

In the tortoise the gastrointestinal movements were observed utilizing the abdominal-window-technique. The results obtained were summarized as follows: (1) So far as the intestine was exposed to the atmosphere both in vivo and in vitro, the intestine was motionless in most cases. On the other hand, the abdominal-window-technique proved to be very useful to observe the gastrointestinal movements. (2) The operation was carried out under the aseptic precaution as follows: First the back of the animal was removed at its left side to make a retangular window of 8 X 1.5-4 cm, then ovaries and fallopian tubes on the left side were removed and lastly the window thus formed was covered with a 0.2 mm thick, transparent vinyl-plate, being sutured at its border to the back. In addition, the border of the window plate was firmly sticked to the back by means of adhesives, Aron Alpha A and Araldite. (3) a. In the region of the stomach situated just anal to the cardia contractions (stomach peristalses) recurrently started with a time interval of 21 to 32 sec, sweeping down the wall of the stomach with a velocity of 0.5 to 0.9 mm/sec, until they came to an end at the pylorus. b. In the small intestine, there recurrently occurred contraction waves with a time interval of about 45 seconds, traveling analwards with a velocity of about 0.3 mm/sec. c. In the large intestine, there were observed two kinds of movements, i.e., antiperistalses as well as mass peristalses. In the former contraction waves recurrently started at the anal end (coprodaeum) of the large intestine with a time interval of 18 to 25 sec, propagating oralwards with a velocity of about 1 min/sec, until they waned rapidly to disappear after propagating only a short distance (about 2 to 3 cm). In the latter powerful contractions occasionally started at the uppermost part of the large intestine to propagate analwards at first slowly with a velocity of about 0.15 mm/sec, and then rapidly with a velocity of about 0.5 mm/sec, until they arrived at the proctodaeum to expel a fecal mass 7 to 8 mm thick and 15 mm long.

Abdomen↗