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Biomedical subjects

T N Krasnova

Publications and source records attributed to T N Krasnova.

25 records · Page 2Linked to original sources
PubMed1991

[The treatment of chronic glomerulonephritis with ultrahigh doses of cyclophosphane].

Pulse therapy with cyclophosphamide was administered to 44 patients with chronic glomerulonephritis of the nephrotic type with different morphological varieties. The treatment was effective in 59% of cases including 11 out of 24 patients resistant to oral treatment with immunosuppressors. The treatment results were better in patients with normal blood serum creatinine and normal arterial pressure. Remission of the nephrotic syndrome could be observed in mesangioproliferative glomerulonephritis, mesangiocapillary glomerulonephritis, mesangial glomerulonephritis and focal-segmentary hyalinosis. In fibroplastic nephritis, remission of the nephrotic syndrome was recorded in none of the cases. The only prognostically significant sign predicting the treatment effect was the activity index--the totality of the morphological signs reflecting nephritis activity. The sclerotic changes produced no significant effect on the treatment outcome.

Adolescent↗
PubMed1990

[Kidney involvement in cryoglobulinemia].

The authors provide the reported data on renal impairment in mixed cryoglobulinemia (CGE) and 3 own CGE case reports. Renal impairment by the type of rapid-progressing nephritis with episodes of acute renal failure was the major sign in the clinical picture of those cases.

Adult↗
PubMed1990

[The action of cyclophosphane in different morphological variants of glomerulonephritis in mice].

Heterologous serum glomerulonephritis (GN) was induced in CBA and C57BL mice. CBA mice developed diffuse proliferative GN. Glomerular changes in C57BL mice corresponded to the mesangial GN with proliferation of glomerular mesangial cells and mesangial infiltration with mononuclear phagocytes. Single administration of cyclophosphamide (CP) at the time of immunization exerted different effect on the development of the two morphological variants of GN. In CBA mice CP treatment resulted in disappearance of the immune complexes deposits with no influence on the cell reactions. In C57BL mice CP completely inhibited the development of the glomerular morphological changes. The lack of morphological similarity is most likely connected with the immunological differences in the histocompatibility complex (H-2).

Animals↗
PubMed1989

[Treatment of chronic glomerulonephritis with cytostatics].

A retrospective analysis was made of the efficacy of oral treatment with cytostatics (azathioprin, batriden, cyclophosphamide) in 109 patients with chronic glomerulonephritis (CGN) (with a known morphologic appearance in 94 patients) and with excessive doses of cyclophosphamide i. v. in 32 patients with CGN depending on the nephritis standing, its clinical pattern and morphologic variant. The best results were recorded with nephritis lasting up to 2 years in patients suffering from the nephrotic pattern of CGN or at the stage of the nephrotic syndrome formation in patients with latent CGN, in membranoproliferative, membranous and membranocapillary versions of CGN, during pulse therapy, and in patients with focal segmental glomerulohyalinosis. No remissions were observed in mixed CGN. The experimental data are also provided concerning the influence of a single oral cyclophosphamide administration on the morphologic signs of nephritis in GBA and C57BL mice.

Animals↗
PubMedDate not supplied

[The bases for the formalization of syndrome diagnosis for an automatic system of patient management].

The paper shows approaches to formalizing the terms "symptom", "symptom-complex", "syndrome", "syndrome-complex" and their quantitative assessments for diagnosis of major renal diseases. The latter are chosen as their diagnosis based on a combination of a great deal of medical parameters, implies virtually all aspects of therapeutical diagnostic activity. Based on qualitative assessments, the authors propose methods for construction of automatic systems for management of patients. The specific algorithms of interaction of databases on major medical parameters, which determine various pathological processes, and that of knowledge background with the rules of diagnostic application of these parameters.

Algorithms↗