Low yield of pulmonary surfactant in cigarette smokers.
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Biomedical subjects
Publications and source records attributed to T N Finley.
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Endobronchial saline lavage was used to obtain acellular material and cells from the dog lung. The centrifuged lavage fluid yielded a sediment consisting of an upper white layer and a lower brown layer. The white layer was strongly surface-active. It consisted of a mixture of lipids and proteins; the composition of the lipid portion was the same in three dogs. The predominant lipids were phosphatidyl choline, cholesterol, and cholesteryl esters; 75-88% of the fatty acids in each phospholipid fraction were saturated. Electron microscopy showed a strong morphological resemblance between the white layer and alveolar lining material in situ.
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