An 8-year-old girl with chronic idiopathic intestinal pseudo-obstruction (CIIP), who is the first case of CIIP in Japan, has been receiving total parenteral nutrition (TPN) for more than 6 years. During this time, she experienced deficiencies of copper, zinc, vitamin A, vitamin B12, folic acid, and biotin, and an excess of vitamin A; she exhibited a series of signs and symptoms due to these deficiencies and vitamin A overdosage. Nevertheless, careful monitoring of serum levels of trace elements and vitamins and appropriate therapy have almost solved these problems. She has achieved normal physical and mental development and goes to school, while receiving home parenteral nutrition with an ambulatory infusion system.

Biotin↗

PubMedDate not supplied

Mitotic figures of glial fibrillary acidic protein-positive cells in the periphery of human brain abscess.

It has been unclear until now as to whether human astrocytes proliferate through mitosis or through amitosis, and little attention has been paid to the biological meaning of glial cell division. We examined an autopsy case of a 53-year-old man who died of brain abscesses and have found GFAP-positive mitotic cells in the zone between the abscess cavity and the reactive gliosis. The results suggest that human normal astrocytes which act in response to the brain abscess proliferate the process of mitosis, and become reactive to repair the lesions.

Astrocytes↗