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Biomedical subjects

T Moshang

Publications and source records attributed to T Moshang.

At least 55 records · Page 3Linked to original sources
PubMed1985

The prolactin response to thyrotropin-releasing hormone does not distinguish teenaged males with hypogonadotropic hypogonadism from those with constitutional delay of growth and development.

We attempted to confirm the results of a previous study in which patients with hypogonadotropic hypogonadism (HH) could be readily distinguished from normal adolescents with constitutional delay of growth and development (CDGD) by their lower serum PRL responses to TRH. We compared the PRL responses to TRH of 13 teenaged males with HH to those of 14 teenaged males with CDGD. Although the mean maximum serum PRL concentration after TRH in HH patients (29.5 ng/ml) was significantly less (P less than 0.05) than that in the CDGD subjects (41.1 ng/ml), there was considerable overlap between the 2 groups. Seven of the 13 HH patients had peak serum PRL concentrations in response to TRH that were greater than 25 ng/ml, the lowest value in the CDGD subjects. These results suggest that a normal PRL response to TRH in a male who has delayed puberty does not exclude the diagnosis of HH, but that a subnormal response probably does support that diagnosis.

Adolescent↗
PubMed1985

Pituitary enlargement mimicking pituitary tumor.

Primary hypothyroidism can result in reactive enlargement of the pituitary gland which is indistinguishable from primary pituitary lesions on computerized tomography (CT) scans. The presenting symptoms may be due to pituitary gland enlargement, as in two of the three cases reported here. Therefore, the diagnosis of pituitary hypertrophy or hyperplasia secondary to hypothyroidism must be based on the endocrinological work-up. Following treatment of primary hypothyroidism, the diminution in size of the pituitary gland can be demonstrated with CT.

Adolescent↗
PubMed1984

Evolution of the hyperandrogenism-polycystic ovary syndrome from isosexual precocious puberty: report of two cases.

Two girls who presented initially with isosexual precocity later developed the hyperandrogenism-polycystic ovary syndrome. We propose that the pathogenesis of the hyperandrogenism-polycystic ovary syndrome in these two children is related to an abnormal release of hypothalamic gonadotropin-releasing hormone, a subsequent sustained secretion of luteinizing hormone, and a consequent excessive secretion of ovarian androgens that results in hyperandrogenism. The clinical findings in these patients suggest that the dysfunction of the hypothalamic-pituitary regulation of luteinizing hormone secretion that leads to the hyperandrogenism-polycystic ovary syndrome may occur prior to puberty.

Adolescent↗
PubMed1981

Growth hormone release in hypertensive adolescents treated with clonidine.

The release of the growth hormone in the basal state and in response to strenuous exercise was studied in a group of 15 hypertensive adolescents receiving clonidine therapy and in a control group of 17 untreated adolescents of which ten were hypertensive volunteers and seven were health normotensive volunteers. Mean basal growth hormone in clonidine-treated adolescents was 2.8 +/- 0.50 S.E.M. ng/ml, compared to 2.7 +/- 0.48 ng/ml in untreated adolescents. Following exercise stimulation, mean growth hormone was 14.8 +/- 3..1 S.E.M. ng/ml in the treated group and 13.5 +/- 2.8 ng/ml in the untreated group. Growth hormone release is regulated by alpha-adrenergic receptor stimulation. Clonidine acts centrally by alpha-adrenergic stimulation. However, this study demonstrates no effect of chronic clonidine therapy on growth hormone release.

Adolescent↗
PubMed1981

Premature thelarche. Natural history and etiologic investigation.

The natural history of premature thelarche was investigated by contacting 46 patients with previously diagnosed cases. Palpable breast tissue had persisted for at least three to five years in 57% of these girls. Only 11% reported that the breasts had continued to enlarge. Those cases in which breast tissue had been present at birth and persisted were significantly more likely to have progressive enlargement. Comparing the cases with matched control subjects showed no relationship between premature thelarche and maternal obstetrical problems, exposure to medications, diet, or prenatal infections. Girls with premature thelarche were no more likely than control subjects to have other sexual or medical problems develop during the period of follow-up.

Breast↗
PubMed1980

Menarchal determinants in cystic fibrosis.

Age, derived fat index (FI), and clinical score at the time of menarche were determined from records of 63 girls with cystic fibrosis (CF) and from 17 comparably aged but nonmenarchal girls with CF. The mean age of menarche in girls with CF was 14.5 years at a mean FI of 20.1% fat; thus, they were significantly older and had less fat than normal girls. Menarchal age was related to severity of illness. Amenorrheic girls with CF, mean age of 14 years, were significantly sicker and smaller. Gonadotropin and estradiol levels in 23 girls with CF were normal. The delay in menarche in CF appears to be closely related to severity of illness. Furthermore, although the relationship of puberty to body composition may or may not be coincidental, it is unlikely that puberty is initiated by a "critical body composition."

Adolescent↗
PubMed1976

Propranolol and exercise as a screening test for growth hormone deficiency.

There is a need for a safe, inexpensive, and reliable screening test for growth hormone (GH) reserve. Exercise has been utilized for this purpose but false-negative responses (inadequate GH release in non-GH-deficient patients) has limited the effectiveness of this stimulus as a screening test. Beta-adrenergic blockade (propranolol) was used to enhance the effect of exercise on GH release. Thirty-two non-GH-deficient children and five GH-deficient children were evaluated. All of the non-GH-deficient children responded to propranolol and exercise with serum GH levels exceeding 7 ng/ml. The peak serum GH levels in the five GH-deficient patients did not exceed 4 ng/ml. Propranolol and exercise appears to be an effective screening test for GH function.

Adolescent↗
PubMed1975

Low serum triiodothyronine in patients with anorexia nervosa.

Patients with anorexia nervosa can demonstrate clinical and/or laboratory findings suggestive of reduced thyroid hormone secretion. In this study, the thyroxine (T4) and triiodothyronine (T3) serum concentrations, and thyrotropin (TSH) response to intravenous administration of thyrotropin releasing hormone (TRH) were determined in 6 patients (aged 9 to 15 yr) with anorexia nervosa and the results compared to those found in a group of 15 normal subjects. The mean basal TSH concentration and mean maximum increase in TSH after TRH were comparable to those in the normal subjects. The mean T4 concentration (7.2 mug/100 ml) in the anorexia nerovsa group was slightly but significantly lower than in the normal group (9.5 mug/100 ml). Five of the 6 patients had serum T3 concentrations below the lower limits of normal and the mean T3 concentrations (49.7 ng/100 ml) was significantly lower than in the normal group (106 ng/100 ml). The extremely low serum levels of T3 in these patients with anorexia nervosa suggest that peripheral conversion of T4 to T3 is impaired during chronic starvation.

Adolescent↗