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Biomedical subjects

T Moriyama

Publications and source records attributed to T Moriyama.

At least 325 records · Page 18Linked to original sources

[A surgical case with traumatic false aneurysm, arteriovenous fistula of the middle meningeal artery, ipsilateral chronic subdural hematoma and contralateral subdural hydroma and nontraumatic vertebrooccipital anastomosis (author's transl)].

A 48-year-old man with traumatic false aneurysm, arteriovenous fistula of the middle meningeal artery, ipsilateral chronic subdural hematoma, contralateral subdural hydroma, and nontraumatic vertebrooccipital anastomosis was reported with a review of the literature. Traumatic false aneurysm of the middle meningeal artery of 32 cases was already reported in the world, and traumatic arteriovenous fistula of the middle meningeal artery was found in 47 cases, but combination of the both is very rare and only 6 including ours have been found in the literature. In a case that a fracture line crosses over the middle meningeal artery, meningeal false aneurysm or arteriovenous fistula as well as epidural or subdural hematoma is supposed. Therefore common carotid angiography or selective carotid external angiography should be examined thinking of these above mentioned lesions. Comment was made from the anatomic, angiographic, and therapeutic point of view. In our case, the false aneurysms were removed while necessary ipsilateral craniotomy was performed for the chronic subdural hematoma. And operative and histological findings suggest the false aneurysms were on the way to spontaneous disappearance.

Adult↗

[Interesting radiological and pathological findings of the internal carotid artery observed in a case of cavernous sinusitis (author's transl)].

A 47-year-old man was admitted to the neurosurgical department of Nagasaki University Hospital with complaints of high fever, deteriorated conciousness and nonpulsating exophthalmus on the left side. The first carotid angiography which had been done 2 days prior to admission, showed only an irregular narrowing in the cavernous portion of the left carotid artery. The right carotid angiogram did not show any recognizable abnormality. The second angiography which was performed 4 days after the admission, revealed an cylindrical aneurysmal opacification about 0.8 cm in diameter in the left intracavernous portion. The right angiography could not be done at that time. On the 47th hospital day, the third angiogram was performed. There noted again, the aneurysmal opacification in the left carotid artery and furthermore, the right carotid artery was occluded completely at its entrance into the cavernous sinus. On post-mortem examination, the cavernous sinus was filled with coagulated blood which drived from the ruptured left internal carotid artery. Microscopic examination revealed marked invasion of leucocytes to the wall of the internal carotid artery at the cavernous portion in both sides. These findings suggested that a mycotic aneurysm which resulted from the cavernous sinusitis ruptured into the left cavernous sinus and spelled blood compressed the opposite (right) carotid artery within the carvernous sinus which resulted in occlusion of the artery.

Carotid Artery, Internal↗

Production of homocytotropic antibody against acid extracts isolated from group A streptococcal cell walls in intact and adrenalectomized rats.

Intact and adrenalectomized rats of male Sprague-Dawley were injected with acid-extracted materials isolated from group A streptococcal cell walls using aluminum gel as an adjuvant. We have clearly demonstrated the production of homocytotropic antibodies against this antigens in rats. However, the homocytotropic antibody titers in adrenalectomized rats were much higher than those in intact rats.

Adrenal Glands↗

[Percutaneous revision of shunt with obstructed ventricular catheter (author's transl)].

Shunt dysfunction due to an obstructed ventricular catheter can be avoided, at least in part, by placing the of the catheter anteriorly to the Foramen of Monro. However, once the catheter is obstructed, surgical removal under general anesthesia is almost inevitable. Irrigation method for an obstructed ventricular catheter enables us to gain scarcely anything and accumulation of instilled fluid in the ventricle often causes the dangerously increased intracranial pressure. 1) Technique for placement of the ventricular catheter. The skin incision is a semicircular. After the skin flap is reflected, "8-shaped" burr hole is placed (Fig. 1 in the text). At first, two openings, large and small, are made in the skull. At 1/4 inch drill is used for making a small hole and a regular perforator for an adjacent large one, then, with a small Schlessinger roungeur, a thin wall dividing these two holes is removed. Two to 3 cm lateral from the midline and also posterior to the frontal hair line is usually chosen for placement of burr holes. A straight ventricular catheter with multiple small perforations at its tip is connected to the Rickham reservoir and inserted in the ventricle anteriorly to the Foramen Monro, through the small hole of the "8-shaped" burr hole. Rest of surgical procedure is performed according to a routine manner. 2) Technique for release of ventricular catheter obstruction by percutaneous management through the "8-shaped" burr hole. A 20-gaze modified spinal needle is inserted through the Rickham reservoir under fluoroscopic control and gradually progressed to the tip of the obstructed catheter. Simple aspiration through the needle may occasionally open the catheter by removing small obstruents, but in many instances, insertion of an another ventricular needle through the large hole and combined irrigation are indispensable. 3) Results. Ten of 72 patients who had placement of the ventricular catheter by this technique developed obstructions of the catheter. Percutaneous technique was successful in releasing the obstructions in 12 times of these 8 patients and remaining 2 patients were subsequently operated upon for the following reasons. One patient, because of dislodging of the reservoir cap after successful release of obstruction and the other, due to extraventricular location of the tip of the catheter prior to the percutaneous management. No serious complications has been encountered and the technique was proved to be safe and simple ensuring good functional return of the shunt in long-term follow-up.

Catheterization↗

Exertional hemoglobinuria.

A 16 years old boy had a typical exertional hemoglobinuria after walking with his new leather shoes on. The attacks of hemoglobinuria were associated with the appearance of an unstable hemoglobin in red cells. A slightly decreased fragility curve by 24 hr incubated red cells, the increase of autohemolysis and the appearance of heat labile hemoglobin were observed after exertion. These findings support that exertional hemoglobinuria may be regarded as a transitory erythropathia.

Adolescent↗

Some Immunochemical Properties of Dextransucrase and Invertase from Streptococcus mutans.

Dextransucrase and invertase of some strains of Streptococcus mutans were examined by immunodiffusion with antisera against enzymes purified from strain HS-6 (Bratthall's serotype a). Both antisera cross-reacted with crude enzyme preparations from the other serotype a (strains HS-1 and AHT) and d organisms (strains KIR, OMZ176, and OMZ65) but not with those from serotype b (strains FA-1 and BHT) or c organisms (strains GS-5, Ingbritt, and NCTC 10449). Based upon the antiserum used, the orders of antigenic similarity of the cross-reacting enzymes to the HS-6 enzymes were HS-6 > HS-1 > AHT = KIR = OMZ176 = OMZ65 for dextransucrase and HS-6 = HS-1 > AHT = KIR = OMZ176 = OMZ65 for invertase. It was found that the enzymes from serotype a organisms were not always antigenically homogeneous, as seen between strains HS-6, HS-1, or AHT for dextransucrase, and between the HS group and strain AHT for invertase. Antiserum against the HS-6 dextransucrase markedly inhibited the heterologous dextransucrases of serotype a organisms with the exception of strain HS-1 and d organisms, with or without the addition of dextran.

Journal Article↗

Purification and properties of dextransucrase and invertase from Streptococcus mutans.

Invertase (beta-d-fructofuranoside fructohydrolase, EC 3.2.1.26) and dextransucrase (alpha-1, 6-glucan: d-fructose 2-glucosyltransferase, EC 2.4.1.5) were purified from the culture fluids of Streptococcus mutans by chromatography on Sepharose 6B and diethylaminoethyl-cellulose followed by treatment with hydroxyapatite. Each of the enzyme preparations gave a single band when analyzed by either polyacrylamide gel electrophoresis or immunodiffusion. The antigenic determinant of invertase was different from that of dextransucrase on immunodiffusion. The pH optima were 5.25 for invertase and 5.75 for dextransucrase, and the K(m) values were 20 mM for invertase and 2.0 mM for dextransucrase. The molecular weights determined by sodium dodecyl sulfate gel electrophoresis were 160,000 for invertase and 170,000 for dextransucrase. The data obtained suggest that the dextransucrase had dextran-synthesizing activity and invertase-like activity.

Carbon Radioisotopes↗

Acceleration of dextransucrase activity of Streptococcus mutans by secretory immunoglobulin A.

The effect of immunoglobulins on the activity of dextransucrase purified from Streptococcus mutans strain HS-6 is described. When human salivary immunoglobulin A (IgA) or colostral IgA, either natured or denatured, was incubated with dextransucrase, the rate of the dextran synthesis was markedly accelerated, whereas human serum IgA or IgG neither accelerated nor inhibited the enzyme activity. The results suggest that a portion unique for secretory IgA, the secretory component, might be related to the enzyme acceleration. On the other hand, specific rabbit antiserum against the dextransucrase inhibited completely dextran synthesis by the enzyme.

Animals↗