Iodine-123-metaiodobenzylguanidine [123I-MIBG] has been used to evaluate the cardiac sympathetic nervous system. We evaluated the effect of pulmonary hypertension on the sympathetic neuronal function of the left ventricle in patients with pulmonary hypertension. We studied 20 patients with either chronic lung disease or pulmonary vascular disease. The patients were divided into a pulmonary hypertensive group and a control group. Single photon emission tomography was performed in the resting state 15 min and 4 h after administration of 123I-MIBG. Regions of interest (ROI) were set in the left ventricular (LV) free wall, the interventricular septum (IVS) and outside the LV free wall on short-axis images. The washout rate and the ROI/LV uptake ratio were calculated in each ROI. The IVS:LV uptake ratio was significantly lower in the pulmonary hypertensive group than in the control group. Our results suggest that left heart sympathetic neuronal dysfunction initially occurs in the IVS before it involves the LV free wall subsequently.

3-Iodobenzylguanidine↗

PubMedDate not supplied

A new test of Eustachian tube function with otoadmittance meter: tubotympanometry.

A new method for testing Eustachian tube function using an otoadmittance meter (Tubotympanometry) is reported. The otoadmittance meter is set for the aural reflex test, namely in the position of Y-T- recording. The patient is asked to carry out deep breathing. Valsalva's maneuvre, normal breathing, and swallowing in succession. In normal 40 ears, three types of the tubotympanogram were classified. In type A, observed in 32 ears, the graph shows no changes during deep breathing, a sudden downward deflection with Valsalva's maneuvre, a return to a level after the maneuvre and on repeated swallowing the graph returns to the initial level in stepwise. In type B, observed in 5 ears, the graph returns to the initial level directly after Valsalva's maneuvre without swallowing. This indicates a slightly patent tube, even though in the normal range. Type C was observed in 3 ears of patients who failed to perform Valsalva's maneuvre correctly. In the case of a patent tube, the graph shows a remarkable fluctuation synchronizing with inspiration and expiration. In the case of an occluded tube, the graph shows slower recovery after Valsalva's maneuvre and no complete return to the initial level even after repeated swallowing. In another case of occluded tube, the graph was deflected upward by Valsalva's maneuvre and showed no change on deglutition. The greatest advantage of this test is the simplicity of the equipment and of the test procedure.

Acoustic Impedance Tests↗

PubMedDate not supplied

The ultrastructure of lymphatic vessels in the human middle ear with cholesteatoma.

Lymphatic vessels were few in the edematous portion of the cholesteatoma perimatrix of the human middle ear. But the lymphatic vessels contained mucus and consisted of degenerated endothelial cells. Edema of the perimatrix was considered to be caused by the degeneration of lymphatic vessels. Normal lymphatic vessels were found in the fibrous perimatrix, while macrophages infiltrated and phagocytosed cell debris. In addition, regenerating blood vessels were observed. Degeneration of connective tissue due to lymphatic edema and its repair were both present in the perimatrix. The degeneration of perimatrix was hypothesized to be caused by confined mucous epithelium behind the cholesteatoma matrix.

Cholesteatoma↗