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Biomedical subjects

T Moore

Publications and source records attributed to T Moore.

At least 145 records · Page 8Linked to original sources
PubMed1990

Lymphocyte proliferative responses to HIV-1 envelope and core antigens by infected and uninfected adults and children.

Lymphocytes derived from children and adults infected with the human immunodeficiency virus (HIV-1), as well as from seronegative children and adults, were tested for their ability to proliferate in response to recombinant HIV envelope (env) and core (cor) peptides. Proliferative responses to env were seen in 9% of control children compared with 27% of infected children (p less than 0.02). There was no difference in the response rates of seropositive and seronegative adults (17% and 16%, respectively). Proliferative responses to cor were seen more frequently in children and adults (22% and 28%, respectively) than their seronegative cohorts (11% and 12%, respectively). Also, the proliferative response to env and cor was seen in 27% and 37%, respectively, of seronegative children who were born to seropositive mothers and then subsequently seroreverted. These results suggest that sensitization to HIV recombinant antigens has resulted in a cell-mediated immune response in some HIV-infected individuals. Furthermore, the significant cell-mediated immune response to these antigens in seroreverting children raises the possibility that they may have been sensitized to this antigen by previous HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1990

A different kind of clinical evaluation instrument for use in a programme in radiography.

Clinical evaluation of radiography students during their performance of non-routine radiographic examinations can be quantified if the proper instrument is used. Such an instrument, referred to as the non-routine radiography examination evaluation by radiographic science faculty at Idaho State University, requires the student to perform a variety of atypical radiography examinations including trauma, paediatrics and portables. This particular instrument provides a mean of documentation and evaluation in an area of student competency which can otherwise be difficult to assess and evaluate.

Documentation↗
PubMed1990

Yaws in the Solomon Islands.

Yaws is a chronic, relapsing, non-venereally transmitted disease caused by Treponema pertenue. As a result of the WHO mass treatment campaign of the late 1950s, the prevalence in the Solomon Islands fell dramatically. Here the disease was thought to have been eradicated until an outbreak occurred in 1981. In 1984 a mass treatment survey following modified WHO guidelines was carried out. Subsequent to this campaign, yaws recurred and in 1987 a further treatment survey was required. Two observations were made as a result of our recent experience in controlling yaws in the Solomon Islands. (1) The disease appears to be attenuated. (2) WHO control policy may now be an inappropriate method for dealing with yaws in the Solomon Islands and should be replaced by a method which is integrated into the existing primary health care (PHC) structure.

Adolescent↗
PubMed1989

Studies of the horizontal vestibulo-ocular reflex in spaceflight.

Changes in the vestibulo-ocular reflex (VOR) during space flight have been suspected of contributing to space motion sickness. The horizontal VOR was studied in nine subjects on two space shuttle missions. Active unpaced head oscillation at 0.3 Hz was used as the stimulus to examine the gain and phase of the VOR with and without visual input, as well as the visual suppression of the reflex. No statistically significant changes were noted inflight in the gains or phase shifts of the VOR during any test condition, or between space motion sickness susceptible and nonsusceptible populations. Although VOR suppression was unaffected by spaceflight, the space motion sickness-susceptible group tended to exhibit greater error in the suppression than the nonsusceptible group. It is concluded that at this stimulus frequency, VOR gain is unaffected by spaceflight, and any minor individual changes do not seem to contribute to space motion sickness.

Adult↗
PubMed1989

Human immunodeficiency virus type 1 antigenemia in children.

Human immunodeficiency virus type 1 (HIV-1) core antigen was assayed in the plasma of children at risk for infection with HIV to determine its usefulness in the diagnosis of infection and to correlate it with the clinical stage of disease. Antigen was detected in the plasma of all children less than 15 months of age with acquired immunodeficiency syndrome (AIDS). Two thirds of children with AIDS-related illnesses and half of children with asymptomatic infection had antigen. Although 53% of plasma specimens originating from HIV-infected children younger than 6 months of age contained antigen, only 25% of plasma specimens from children younger than 6 months who had no symptoms and none of the 10 specimens from HIV-infected newborn infants contained antigen. Half of the specimens containing core antigen also contained anticore antibody. Quantitative mean antigen levels were more likely to be elevated in children with AIDS (516 pg/ml) than in children with AIDS-related illnesses (295 pg/ml) or in those who had no symptoms (70 pg/ml). Antigen levels tended to increase over time in children with advancing clinical illness, but they tended to decrease over time after a diagnosis of AIDS was made. Antigen was detected in the plasma of 4 of 14 children without symptoms who subsequently reverted to an HIV seronegative state. We conclude that the detection of core antigen occurs with high frequency in children, even young infants, with symptomatic HIV infection. Plasma core antigen was less frequent in children without symptoms and was not detected in 10 infected children when they were tested at birth.

AIDS-Related Complex↗
PubMed1989

Cloning and expression of a protective antigen from the cattle tick Boophilus microplus.

Glycoproteins located on the luminal surface of the plasma membrane of tick gut epithelial cells, when used to vaccinate cattle, are capable of stimulating an immune response that protects cattle against subsequent tick infestation. One such tick gut glycoprotein, designated Bm86, has been purified to homogeneity and the amino acid sequences of peptide fragments generated by endoproteinase Lys-C digestion have been determined. We report here the isolation and characterization of a cDNA that encodes Bm86. The nucleotide sequence of the cDNA contains a 1982-base-pair open reading frame and predicts that Bm86 contains 650 amino acids including a 19-amino acid signal sequence and a 23-amino acid hydrophobic region adjacent to the carboxyl terminus. The main feature of the deduced protein sequence is the repeated pattern of 6 cysteine residues, suggesting the presence of several epidermal growth factor-like domains. A fusion protein consisting of 599 amino acids of Bm86 and 651 amino acids of beta-galactosidase was expressed in Escherichia coli as inclusion bodies. Ticks engorging on cattle vaccinated with these inclusion bodies were significantly damaged as a result of the immune response against the cloned antigen.

Amino Acid Sequence↗
PubMed1989

Exercise-training protocols for astronauts in microgravity.

The question of the composition of exercise protocols for use by astronauts in microgravity is unresolved. Based on our knowledge of physical working requirements for astronauts during intra- and extravehicular activity and on the findings from bed-rest studies that utilized exercise training as a countermeasure for the reduction of aerobic power, deterioration of muscular strength and endurance, decrements in mood and cognitive performance, and possibly for bone loss, two exercise protocols are proposed. One assumes that, during microgravity, astronaut exercise physiological functions should be maintained at 100% of ground-based levels; the other assumes that maximal aerobic power in flight can be reduced by 10% of the ground-based level. A recommended prescription for in-flight prevention or partial suppression of calcium (bone) loss cannot be written until further research findings are obtained that elucidate the site, the magnitude, and the mechanism of the changes. Hopefully these proposed exercise prescriptions will stimulate further research and discussion resulting in even more efficient protocols that will help ensure the optimal health and well-being of our astronauts.

Exercise↗
PubMed1989

Multifocal glioblastoma with liver metastases in the absence of surgery. Case report.

A patient with two intracerebral glioblastomas of differing histology with metastases to the liver in the absence of surgery is reported. The gliomatous nature of the lesions was confirmed by staining for glial fibrillary acidic protein. Histological and immunohistochemical evidence suggests that the metastases arose from the more poorly differentiated of the intracerebral tumors. One of the intracerebral tumors had enhanced expression of the ras p21 oncogene as compared to the other tumors and as compared to nonmalignant brain tissue from this patient.

Aged↗
PubMed1989

Employee assistance program evaluation. Employee perceptions, awareness, and utilization.

Periodic evaluation is necessary to maintain a quality employee assistance program. This survey was undertaken to determine employee awareness of the existing EAP and their satisfaction with the program. Likewise, the survey allowed for employee input on areas of the program they had concerns with that may have caused hesitancy in further use of the program. The survey not only documents to management that the program is of value to employees and identifies areas where changes may be focused in the future to meet employee needs, but actually serves as a communication tool in itself as a reminder of the availability of the Employee Assistance Program.

Adult↗