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Biomedical subjects

T Moore

Publications and source records attributed to T Moore.

At least 199 records · Page 11Linked to original sources
PubMed1983

Effects of low concentrations of chlorine on pulmonary function in humans.

Eight healthy unacclimated volunteers were exposed to chlorine gas in concentrations of 0.5 or 1 ppm, and several pulmonary function measurements were made. Comparisons were made by paired t test between the percent change from base-line values obtained at various times after chlorine exposure and the percent change from base line at analogous times after a sham exposure. With the sham vs. 0.5-ppm exposure, there were trivial changes observed. Total lung capacity (TLC) was lower before 0.5-ppm exposure than before sham exposure, and the percent decrease in carbon dioxide pulmonary diffusing capacity was smaller 24 h after 0.5-ppm exposure than 24 h after sham exposure. With the sham vs. 1-ppm exposure, there were many differences in percent change from base line that were significant at the P less than 0.05 level or better. These were in forced vital capacity (FVC), forced expiratory volume at 1 s (FEV1), peak expiratory flow rate (PEFR), forced expiratory flow rate at 50 and 25% vital capacity (FEF50 and FEF25, respectively), and airway resistance (Raw). There were, in addition, significant changes after only 4 h of exposure. These were in FEV1, PEFR, FEF50, FEF25, TLC, Raw, and the difference in nitrogen concentration. Most of the test results had returned to normal by the next day. We conclude that even though chlorine at low concentrations does not produce any serious subjective symptoms, it adversely affects pulmonary function transiently.

Adult↗
PubMed1981

Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study.

Between June 1977 and December 1978, occult testicular leukemia (OTL) was discovered at three years of continual complete remission (CCR) from the time of diagnosis of acute lymphoblastic leukemia (ALL) in 5 of 59 (8.5%) of males undergoing bilateral wedge testicular biopsy at 1 of 15 participating Southwest Oncology Group (SWOG) institutions. Forty-six of the 54 males with normal biopsies (78% of the total group of 59) have remained free of recurrent ALL at a median of 18 months (range 13 to 23 months) since the biopsy procedure, whereas eight have relapsed for the first time--five bone marrow (BM), one sclera, one simultaneous BM and testes, and one testes--at a median of 12.5 months (range 4 to 22 months) after the normal testicular biopsy. With aggressive therapy after biopsy in the five boys with OTL, one has died 19 months after biopsy (after two BM relapses), one is alive 21 months after biopsy (after two BM relapses), and three are alive and free of recurrent ALL 13, 16, and 19 months, respectively, since the diagnosis of OTL.

Biopsy↗
PubMed1981

Resistance of neonatal human lymphoid cells to infection by herpes simplex virus overcome by aging cells in culture.

Mononuclear leukocytes freshly harvested from human umbilical cord blood were refractory to infection by herpes simplex virus (HSV) type 1, whereas cells aged in vitro for a week produced 10- to 100-fold or greater more virus. Increased sensitivity of aged cells to infection by HSV was not dependent on active DNA synthesis by the cells at the time of exposure to HSV. The aging phenomenon was not due to the outgrowth of a specific cell subpopulation that is uniquely susceptible to HSV because increased sensitivity to HSV type 1 occurred in a variety of cell subpopulations enriched or depleted of T lymphocytes, phagocytic cells, or adherent cells. About 25% of aged cells contained virions detectable by electron microscopy, considerably more cells than formed infectious centers. These virions were seen in large activated lymphocytes which are the principal cell subpopulation present in the aged cultures, but virions were also seen in small lymphocytes.

Animals↗
PubMed1979

Hypervitaminosis A combined with calcium deficiency in rats.

Weanling male rats were fed for 24 days on a meat diet. Some received supplements of CaCO3, but others did not. For the final 14 days of the experiment some of the rats were given massive doses of retinol as retinyl acetate, but others were undosed. Some of the rats not given retinol had their food intakes paired with those given retinol. Skeletal examinations were made by radiography, and postmortem by measurement of the femur ash contents. The meat diet regularly reduced the femur ash to about half its normal level, but the CaCO3 supplements prevented any reduction. Skeletal fractures occurred consistently in all the rats given retinol, and with little if any difference in severity between the Ca-deficient and Ca-supplemented animals. Histological studies confirmed the accumulation of abnormal amounts of lipid round the liver Kupffer cells in hypervitaminosis A. Chemical estimations of liver fat gave higher values for the retinol-dosed animals than for their controls on paired food intakes. For control rats on unrestricted food intakes, however, higher values than for the retinol-dosed animals were found, but without lipid depositions round the Kupffer cells.

Animals↗
PubMed1976

Complications of Meckel's diverticulum.

This paper reviews the presentation and surgical pathology of 50 Meckel's diverticula encountered in one hospital in a 20-year period. It is concluded that in children with intestinal bleeding or a "raspberry tumour" of the umbilicus a Meckel's diverticulum is usually suspected. In adults with an acute surgical emergency Meckel's diverticulum is unlikely to be considered. However, a Meckel's diverticulum can give rise to surgical problems in many ways and at any age. In particular, the possiblity of an attached mesodiverticular band leading to obstruction must be stressed.

Acute Disease↗
PubMed1976

Carrier detection in classic hemophilia by combined measurement of immunologic (VIII AGN) and procoagulant (VIII AHF) activities.

Accurate carrier detection in classic hemophilia has been difficult because of (1) technical problems related to the performance of both immunologic (VIII AGN) and procoagulant (VIII AHF) determinations, and (2) statistical problems related to the analysis of these data. VIII AHF was determined by a one-stage assay based on the partial thromboplastin time (PTT). VIII AGN was measured by the method of quantitative immunoelectrophoresis. The discriminant function U. = 0.67 1n (AHF) -- 3.17 AGN X 10(-3) was calculated for a validation group of 20 normal persons and for seven obligate carriers, and tested for accuracy of prediction on a cross-validation group of seven additional normal women and ten additional obligate carriers. A U. score of greater than or equal to 2.54 correctly identified 25 of 27 normal persons. Sixteen of 17 obligate carriers had U. scores below 2.54. In addition, of seven possilbe carriers, four were identified as normal and three as carriers. Five normal women taking oral contraceptives had disproportionately high U. scores. It is concluded that detection of carriers of classic hemophilia should be possible in the clinical laboratory by calculation of a discriminant function from combined measurements of VIII AGN and VIII AHF.

Adolescent↗