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Biomedical subjects

T Momose

Publications and source records attributed to T Momose.

At least 145 records · Page 8Linked to original sources
PubMed1984

Determination of peptidoaminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites in human plasma by capillary gas chromatography negative ion chemical ionization mass spectrometry--2.

The capillary gas chromatographic negative ion chemical ionization mass spectrometric assay of peptidoaminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) (1) and its three metabolites in human plasma reported in Part 1 was changed as follows: (1) the reagent gas was changed to ammonia from isobutane; (2) each unlabelled compound (1%) was added to the deuterium-labelled compound used as the internal standard; (3) all samples were injected in the splitless mode; (4) one more metabolite, lormetazepam, was determined; (5) day-to-day reproducibility was checked in the range of 1-50 ng ml-1. Points 1 to 3 improved the preciseness with small-sized samples. Calibration curves were prepared in the range of 0.5-50 ng ml-1. Plasma levels of compound 1 and its four metabolites in 10 volunteers were measured.

Gas Chromatography-Mass Spectrometry↗
PubMed1984

[Pressure control of a pressurized proportional counter for 4 pi beta-gamma coincidence counting--effects of pressure variation and study of a non-flow type system].

Effects of the pressure variation of counting gas on the efficiency function were examined using a 4 pi beta-gamma coincidence counting system with a pressurized proportional counter. The results showed that the pressure variation of about ten kPa could not give large effects on the efficiency function and that a non-flow type of pressurized proportional counter with a simple gas control system could work well in the case of the pressure higher than 1 MPa, an ordinary pressure for the counting.

Beta Particles↗
PubMed1983

Analysis of deposits on high water content contact lenses.

Deposits on soft contact lenses of high water content were investigated morphologically and chemically and compared with those on conventional soft contact lenses of poly (2-hydroxyethyl methacrylate). The material of the lenses examined in this investigation was the crosslinked copolymer of methyl methacrylate and N-vinylpyrrolidone with a water content higher than 70%. Morphologically, the deposits on the lenses with high water content were found to have no characteristics distinguishable from those on conventional lenses. By the electron microscopic observation of the cross section of a lens that had become opaque, it was confirmed that the deposit was on the lens surface and that no deposit was within the lens. Some spots on the lenses were recognized as colonies of microorganisms, but the majority of the spots had no involvement by microorganisms. Surface analysis with Fourier transform infrared spectrometer (FT-IR) confirmed that the main component of the filmy deposit was protein. Protein was detected in most of the deposits. The amino acid compositions of the proteins were found to be close to that of lysozyme. From the elemental analysis of several spots, silicon, aluminum, iron, and some other elements were detected. The structural analysis of some spots by a laser Raman microprobe (MOLE) revealed the existence of lipids. In several cases, the deposits were found to have grown around a defect of the lens surface. A mechanism for the formation of deposits is suggested.

Amino Acids↗
PubMed1983

Effectiveness of zopiclone as a preoperative hypnotic.

A controlled, double-blind study was made of the efficacy and safety of a new hypnotic, zopiclone, on the preoperative night's sleep by a Joint Study Unit Group of the anesthesiology departments in 6 national hospitals. The following results were found: (1) zopiclone 7.5 and 10 mg and nitrazepam 10 mg were significantly superior to placebo both on the quality of sleep and the mental state of the patient, while no significant differences were observed among these three active drugs; (2) a significantly higher incidence of side-effects was observed for nitrazepam 10 mg than for zopiclone 7.5 and 10 mg and placebo; (3) zopiclone 7.5 and 10 mg and also nitrazepam 10 mg were significantly more useful than placebo, and (4) the above results show that 7.5 and 10 mg of zopiclone are of great benefit to the preoperative night's sleep and have less side-effects than 10 mg of nitrazepam.

Adult↗
PubMed1983

Inhibitory effects of unsaturated fatty acids of trans-2-C10:1 to trans-2-C16:1 several C18:n and C20:n on gastric secretion and experimental ulceration in rats.

Among various unsaturated fatty acids which were examined in this experiment, trans-2-tridecenoic acid was found to be a potent inhibitor on gastric secretion in rats (i.p. or i.d.). Therefore, the effects of trans-2-tridecenoic acid on several experimental ulcerations in rats were examined. At the dose of 10 mg/kg, trans-2-tridecenoic acid significantly decreased the ulcer index in pylorus-ligated rats; aspirin-, phenylbutazone-, histamine- and stress-induced ulcerations were also significantly inhibited at the dose of 25 mg/kg. Finally, effects of trans-2-tridecenoic acid on hexosamine and sialic acid contents in the gastric mucous were examined. In intact or phenylbutazone-induced ulcerated rats, trans-2-tridecenoic acid increased the sialic acid levels in the gastric mucous at the dose of 25 mg/kg. The decreased hexosamine content in the gastric mucous by phenylbutazone treatment was recovered by the administration of trans-2-tridecenoic acid.

Animals↗
PubMed1982

Determination of peptidoaminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites in human plasma by glass capillary gas chromatography negative ion chemical ionization mass spectrometry--1.

A highly sensitive and selective glass capillary gas chromatographic negative ion chemical ionization mass spectrometric assay was developed to measure peptidoaminobenzophenone(2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites; chlorodiazepam, chlorodesmethyldiazepam and lorazepam in human plasma. As peptidoaminobenzophenone underwent pyrolysis during gas chromatography, it was converted to a thermally stable aminoquinolone. Internal standards for these compounds were the respective deuterium labelled compounds. Calibration curves were prepared for the range of 1-100 ng ml-1. Interference by endogenous substances was negligible in the isobutane negative ion chemical ionization mode in contrast to the electron impact or positive ion chemical ionization mode. This method was used to determine the plasma levels in humans following oral administration of two 5 mg doses.

Anti-Anxiety Agents↗
PubMed1982

Effectiveness of zopiclone as a preoperative hypnotic.

A controlled, double-blind study was made of the efficacy and safety of a new hypnotic, zopiclone, on the preoperative night's sleep by a Joint Study Unit Group of the anesthesiology departments in 6 national hospitals. The following results were found: (1) zopiclone 7.5 and 10 mg and nitrazepam 10 mg were significantly superior to placebo both on the quality of sleep and the mental state of the patient, while no significant differences were observed among these three active drugs; (2) a significantly higher incidence of side-effects was observed for nitrazepam 10 mg than for zopiclone 7.5 and 10 mg and placebo; (3) zopiclone 7.5 and 10 mg and also nitrazepam 10 mg were significantly more useful than placebo, and (4) the above results show that 7.5 and 10 mg of zopiclone are of great benefit to the preoperative night's sleep and have less side-effects than 10 mg of nitrazepam.

Adult↗
PubMed1980

Mechanical properties of the soft contact lens of poly(methyl methacrylate-N-vinylpyrrolidone).

The mechanical properties of the hydrogel membrane of poly(methyl methacrylate-N-vinylpyrrolidone) were studied for the purpose of making soft contact lenses for extended wear. The dependence of tensile fracture energy, flexibility, and recovery from deformation on the water content and thickness of the hydrogel membrane was studied. Reducing the thickness of a lens was found to exert a more advantageous effect than increasing its water content on maximizing the tensile fracture energy under the condition of an adequate supply of oxygen to the cornea through the contact lens. As long as its water content is controlled between 63 and 78%, the contact lens made of poly(methyl methacrylate-N-vinylpyrrolidone) has the flexibility on the same order as that of conventional soft contact lenses of poly(2-hydroxyethyl methacrylate). The rate of recovery from deformation increases with water content, and the residual elongation is negligible in the range of water content over about 70%. It is concluded that practical requirements for use of these contact lenses, determined by these three mechanical properties, can be satisfied at the same time if the water content of the contact lens is adjusted at about 70%.

Contact Lenses, Hydrophilic↗
PubMed1979

The significance of drug analysis of sweat in respect to rapid screening for drug abuse.

Morphine and methamphetamine, which are excreted in the sweat, are detected by the use of routine serological and physicochemical techniques for urinary examinations. Screening for drug abuse can be done with the same accuracy of that of urine. Rapid excretion of the drug via kidney (within one day) is followed by a slow but steady excretion of the sweat gland. Methamphetamine given orally in a dose of 10 mg is excreted in the sweat at a constant rate (1.4 microgram/ml). No significant difference of the amount excreted by both systems is found. Alveolar lining seems to prevent the elimination of the volatile methamphetamine via respiration. Not only narcotics and stimulants, but also many alkaloids and barbituarates are excreted in the sweat and detected quantitatively by the same principles. The toxicological analysis of the sweat promises a new scope of forensic investigation.

Forensic Medicine↗