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T Mizoguchi

Publications and source records attributed to T Mizoguchi.

204 records · Page 12Linked to original sources
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Kindling epileptogenesis in orbital and mesial frontal cortical areas of subhuman primates.

Despite ready bilateralization of ictal and interictal EEG discharge throughout cortical kindling, the rate of convulsive seizure development was slow at both orbital and mesial frontal sites, even in the epileptic baboon. However, convulsive generalization occurred swiftly from the mesial frontal cortical (MF) sites once conjugate head, eye, and body adversion developed in the three primate species examined. Only epileptic baboons developed Stage 5 bisymmetrical and bisynchronous convulsion. Stimulation of the contralateral homotopic mesial cortical site readily produced afterdischarge that remained localized and convulsive seizure development did not occur. The findings suggest that (a) the frontal lobe plays an important role in the generation of nonconvulsive seizures, (b) the frontorolandic cortex plays a unique role in convulsive seizure generalization, (c) the role of the intrinsic (genetic) factor is significant in determining the quality of the kindled seizure, and (d) the development of focal epileptogenesis at one MF site interferes with clinical seizure development at the "mirror focus." Our findings underscore (a) the necessity of the conceptual differentiation between the EEG mirror focus and the epileptogenic focus capable of generating clinical seizures and (b) the importance of dissecting interictal behavior reflecting a "continuous disorder of neuronal function," which may cause symptoms other than seizures.

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PubMedDate not supplied

Histopathological safety evaluation of polyethylene glycol applied subcutaneously in mice.

Polyethylene glycol is used as a non-aqueous solvent for a variety of medical agents. We believe it could also be used as a base component in root canal filling material and aimed to test the histological safety of subcutaneously injected polyethylene glycol. We injected polyethylene glycol subcutaneously into the dorsal area of 30 6-week-old anaesthetized male ddY mice. An equal number of mice were injected with propylene glycol as controls. One week, 3 weeks and 9 weeks after injection, the tissue surrounding the injection site was removed from 10 mice in each group and examined. We found no histopathological changes, degeneration, necrosis, foreign body reactions or granulation tissue proliferation in either group. Some inflammatory cell infiltration was observed in both groups. Based on these results, we believe that polyethylene glycol could be used safely as a base component of biomaterials for internal medical use, such as in root canal filling material.

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