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Biomedical subjects

T Miyagishima

Publications and source records attributed to T Miyagishima.

49 records · Page 3Linked to original sources
PubMed1986

[Carcinoid of the papilla of Vater-somatostatinoma--a case report].

A 46-year-old woman was referred to our hospital because of liver dysfunction. She had been suffering from right hypochondralgia for two months. On admission, Laboratory data indicated extrahepatic cholestasis. Both X-ray and endoscopic examinations confirm a submucosal tumor of the papilla of Vater, and surgical diagnosis was performed. Histologically, the tumor was diagnosed as carcinoid, and a further immunohistochemical study by the PAP method using antisomatostatin serum indicated somatostatinoma. Electron microscopically, the tumor cells were found to contain numerous intracellular granules, which looked like D cells in the pancreatic islet. Somatostatinoma in the intestinal tract has been reported in only 13 cases, in only one of which was it located in the papilla of Vater. That means that, this is the second case so far.

Adenoma, Islet Cell↗
PubMed1984

Effects of enflurane on excitation-contraction coupling in frog skeletal muscle fibers.

The effect of enflurane on the excitation-contraction (E-C) coupling of frog skeletal muscle fiber was studied. Low (19.13 +/- 0.70 mg%) and high (108.52 +/- 4.52 mg%) concentrations of enflurane did not cause substantial changes of the resting membrane potential but a high concentration of enflurane reduced the peak of action potentials and prolonged the duration measured at 50% peak amplitude. During the twitch response, enflurane reduced the peak response of light signal measured with calcium-sensitive photoprotein, aequorin, but peak tension was not diminished by a low concentration of enflurane. A high concentration of enflurane remarkably inhibited both light signal and tension. During tetanus, a low concentration of enflurane partially abolished light signal and tension. At the high concentration, this inhibitory effect was pronounced and action potentials were only observed in the initial phase of tetanic stimulation. Enflurane enhanced the increase of light signal observed in rapid cooling contracture. In glycerinated muscle fiber, enflurane shifted the pCa-tension relation to the left in low calcium and suppressed maximally activated tension at high calcium concentration. Inhibitory effect of enflurane on light signal in twitch response without abolition of action potential suggests that enflurane might inhibit E-C coupling in frog skeletal muscle fiber (but it enhances direct calcium release from SR induced by caffeine) and increase calcium sensitivity of contractile element.

Action Potentials↗
PubMed1983

Synthesis and antibacterial activity of asparagine derivatives of aminobenzylpenicillin.

In order to improve the antibacterial activity of aminobenzylpenicillin, penicillin derivatives having an asparagine moiety in the 6-acyl side chain (11a approximately g, 12a, b, f, g) were synthesized. The structure-activity relationship of new penicillins, N4-alkyl-asparaginylaminobenzylpenicillins, was investigated. N4-Methyl-D-asparaginylamoxicillin (11a), TA-058, was found to possess a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria. In acute toxicity, TA-058 showed good tolerance in mice (LD50 greater than 10 g/kg, i.v.).

Amoxicillin↗