Search PubMed⌕ Search

Biomedical subjects

T Mitsui

Publications and source records attributed to T Mitsui.

At least 397 records · Page 22Linked to original sources
PubMed1982

[Effect of infusion therapy on intrauterine fetal growth retardation (author's transl)].

It is requested for the control to the intrauterine fetal growth retardation (IUGR) to clarify the cause-and-effect relationship and to take the proper treatment under such a precondition. Following report covers the clinical report on the maternal infusion therapy mainly consisting of amino acids. 1) In the cases, to which the diagnosis of IUGR was given on basis of the development of symphisis-fundus length on the pregnogram and the fetal biparietal diameter (BPD), the occurrence of appropriate-for-gestational-age (AGA) is as extremely high as 44.5% when it is felt without treatment. In the abnormal patterns of symphisis-fundus length, consisting mainly of the threatened premature labor, the differential diagnosis is needed to the outward IUGR. 2) As the effect of the maternal infusion therapy mainly of amino acids on IUGR, given in addition to the oral nutrition, the increase of placental weight and fetal weight was observed at around NP-Cal/N of 99-116. No abnormality was observed in the maternal renal and liver function. 3) As the result of the maternal infusion therapy to 131 cases of IUGR, the occurrence ratio of the small-for-gestational-age (SGA) was 26.7%. No case of perinatal death or congenital malformation was observed.

Adult↗
PubMed1982

Successful excision of intracardiac teratoma.

A 6-year-old boy underwent successful extirpation of an intracardiac teratoma without injury to the myocardium or conduction system. Before operation, two-dimensional echocardiographic examination indicated a possibility of the teratoma. This is believed to be the seventh case to be reported and the second case of successful excision for an intracardiac teratoma.

Child↗
PubMed1981

Neuroendocrine carcinoma (trabecular carcinoma) of the skin with ectopic ACTH production.

A case of ACTH-producing cutaneous neuroendocrine carcinoma occurring in the cheek of an 80-year-old woman is reported. The tumor was composed of undifferentiated cells which had a uniform round nucleus and scanty cytoplasm containing argyrophil granules. An ultrastructural study demonstrated neurosecretory-type granules in the cytoplasm of the tumor cells. Radioimmunoassay revealed an elevated level of ACTH in tumor tissue as well as in the plasma of the patient. This is believed to be the first documented case of ACTH-producing neuroendocrine carcinoma (trabecular carcinoma) of the skin.

Adenocarcinoma↗
PubMed1981

Ultrastructure of adult T-cell leukemia/lymphoma.

Eighteen cases of adult T-cell leukemia/lymphoma (ATLL) in Japan were analyzed by electron microscopy and compared with 5 cases of B-lymphoma and well-established groups of T-lymphomas (4 cases of T-lymphoblastic lymphoma and 2 cases of Sézary syndrome). Five hundred cells in each case, categorized ultrastructurally as to the cellular size and nuclear shape, showed an essentially pleomorphic cellular distribution in ATLL in remarkable contrast with the monomorphism of B-"histiocytic", B-well-differentiated lymphocytic, and T-lymphoblastic lymphomas. Some B-lymphomas and Sézary syndrome also showed pleomorphism. Cases of ATLL were classified according to the predominant cells and degree of nuclear irregularity, which delineated a spectrum of node-based, peripheral T-cells neoplasms probably encompassing T-immunoblastic sarcoma, T-zone lymphoma, as well as multilobated T-cell lymphoma. The characteristic fine structure of ATLL, in comparison with that of B-lymphomas, included slight to marked nuclear irregularity with convoluted-shape predominance, a specked chromatin pattern of the large cells, prominent lysosomes, and glycogen accumulation in addition to the difference in cellular distribution. Although T-lymphoblastic lymphoma and Sézary syndrome shared some of these features, the ultrastructural differentiation of ATLL from them seems to be possible.

Adult↗
PubMed1981

[Cardiovascular and metabolic effects during longtime treatment with beta 2-stimulants (author's transl)].

To study the influence of beta 2-stimulants on pregnant woman and fetus from cardiovascular and metabolic viewpoint, tests were conducted on pregnant rats and human clinical cases of threatened premature labor. 1) When terbutaline 800 micrograms was administered to groups of pregnant rats for 4 days and 8 days, body weight, and weight of liver, placenta and heart of both mother and fetus indicated the trend of decrease when compared to the control, but the difference was not statistically significant. 2) Concentration of c-AMP in the fetal serum was found to be less than the control (P less than 0.001) under the above conditions and consequently c-AMP/c-GMP indicated decrease. Concentrations of c-AMP and c-GMP in the maternal, fetal cardiac tissue were in a decreasing tendency in the terbutaline group. In the patholo-histological studies, terbutaline-induced myocardial necrosis was not observed. 3) In the past five years, of the terbutaline treated cases, specifically 15 cases of large dose and long period of administration were analyzed and the prognosis of their children were followed up. The doses were 20.6 mg (iv, im), and 1276 mg (po), arrest less than 37W was noted in four cases, but onset of SFD was not observed. During the administration term, no abnormality of mothers was noted before and after delivery, and unusual phenomenon was not recognized in the prognosis traced on newborns.

Adult↗
PubMed1981

[Beta 1-, beta 2-effects of ritrodine and terbutaline in the treatment of preterm labor (author's transl)].

beta 2-Stimulants are at present the most effective tocolytic agents. The aim of the study was to evaluate the beta 1- . beta 2-effects of terbutaline and ritodrine in the treatment of preterm labor. 1) Terbutaline, administered intravenously at a rate of 0.4-1.2 microgram/min, and ritodrine also at a rate of 50-300 microgram/min, effectively inhibited uterine activity during 180 minutes. Among the patients there was no difference in responses between those who received terbutaline and ritodrine. 2) The levels of c-AMP and c-GMP in the blood after administration of terbutaline or ritodrine increased and showed dose-response. The levels of c-AMP during a 180-minute infusion increased from 15 to 27 pmol/ml. 3) The action of c-AMP related substances on the circulatory systems was manifested as the dose-response of beta 1 action to the maternal blood pressure, maternal and fetal heart rate. Both beta 2-stimulants produced a tolerable changes in maternal heart rate and blood pressure, no significant changes during the infusion.

Cyclic AMP↗