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Biomedical subjects

T Mitsui

Publications and source records attributed to T Mitsui.

At least 343 records · Page 19Linked to original sources
PubMed1986

Radical surgical cure of Wolff-Parkinson-White syndrome: the Kanazawa experience.

Between 1973 and 1983, we operated on 160 patients with Wolff-Parkinson-White syndrome at Kanazawa University Hospital; 126 had Wolff-Parkinson-White syndrome alone, and 34 had combined cardiac diseases. Of the 160 patients, 140 were completely cured; postoperatively, they had no delta wave on electrocardiograms and no tachycardia attacks. In 11 patients, the delta wave reappeared an average of 56 days after operation. They, and three other patients with concealed Wolff-Parkinson-White syndrome, experienced several postoperative episodes of tachycardia. However, in 12 of the 14 patients with postoperative tachycardia attacks, these disappeared completely in the course of a long follow-up period and these patients are also considered to be cured symptomatically. In the two remaining patients, the tachycardia attacks persisted. Of the 126 patients with Wolff-Parkinson-White syndrome alone, none died as a direct result of the operation. Patients with combined cardiac diseases other than cardiomyopathy, mild Ebstein's anomaly, or venous abnormality were treated in one operation. Six of the 34 patients with combined cardiac diseases died. In none of the 160 patients was the His bundle intentionally interrupted as an alternative method of interrupting the accessory conduction pathway. Our study showed that life-threatening arrhythmias occur more often than expected in patients with Wolff-Parkinson-White syndrome and the tolerance for tachycardia attacks differs from patient to patient. Because the surgical treatment of Wolff-Parkinson-White syndrome is safe and reliable, as indicated in this report, the radical correction of this disease should be considered in carefully evaluated patients.

Adolescent↗
PubMed1985

Biosynthesis of rice seed alpha-amylase: two pathways of amylase secretion by the scutellum.

The alpha-amylase molecule secreted from the scutellar tissues of rice seedlings bears asparagine-linked oligosaccharides which include both (modified) complex-type and high-mannose-type structures. On the basis of their sensitivity to endo-beta-N-acetylglucosaminidase (Endo-beta-H), they are designated as R and S types. When labeled with [3H]fucose a typical R-type alpha-amylase is labeled. By contrast, [3H]mannose-labeled alpha-amylase can be partly digested by Endo-beta-H; hence, it contains both R and S molecules. The role of the Golgi complex in the post-translational oligosaccharide maturation of alpha-amylase was explored by use of the carboxylic ionophore, monensin (10(-7)M), a known perturbant of the structure and function of the Golgi complex. The monensin sensitivity of alpha-amylase transport and acquisition of terminal sugars as well as the morphologic consequences of monensin treatment point to a similarity between the Golgi complex of plant and animal cells. In order to elucidate the relationship between the secretion of two different forms of alpha-amylase and the partial inhibitory effect exerted by monensin, the possible role of Ca2+ in the secretory pathway was examined. The secretion of the R form was stimulated by Ca2+, whereas that of the S form was not affected by the external concentration of Ca2+. In pulse-chase experiments, we found that R-type alpha-amylase accumulates intracellularly under Ca2+-free conditions. These results indicate that there is both Ca2+-dependent and Ca2+-independent secretion of alpha-amylase in the rice scutellar epithelium cells.

Biological Transport↗
PubMed1985

Acute spontaneous subdural hematoma of arterial origin.

A patient is described who had a history of sudden vomiting and rapidly becoming deeply unconscious. There was no history of head trauma. The cause turned out to be an acute spontaneous subdural hematoma from arterial rupture. Comparable cases in the literature are reviewed and the etiological possibilities are discussed.

Adult↗
PubMed1985

Ultrasonic aspiration in coronary artery surgery.

With the aid of an ultrasonically powered aspiration device, the coronary artery to undergo distal anastomosis during aortocoronary bypass grafting can be exposed in the beating heart prior to institution of cardiopulmonary bypass and systemic administration of heparin. The thick adipose tissue and bridging muscles of the superficial layer are removed with almost no bleeding, leaving the vascular elements intact. The optimal site for anastomosis of the coronary artery is readily exposed and confirmed, and aortic cross-clamp time is minimized.

Coronary Vessels↗
PubMed1985

Time-resolved x-ray diffraction studies on the intensity changes of the 5.9 and 5.1 nm actin layer lines from frog skeletal muscle during an isometric tetanus using synchrotron radiation.

Time-resolved x-ray diffraction studies have been made on the 5.9- and 5.1-nm actin layer lines from frog skeletal muscles during an isometric tetanus at 6 degrees C, using synchrotron radiation. The integrated intensities of these actin layer lines were found to increase during a tetanus by 30-50% for the 5.9-nm reflection and approximately 70% for the 5.1-nm reflection of the resting values. The intensity increase of both reflections was greater than that taking place in the transition from rest to rigor state. The intensity change of the 5.9-nm reflection preceded those of the myosin 42.9-nm off-meridional reflection and of the equatorial reflections, as well as the isometric tension development. The intensity profile of the 5.9-nm layer line during contraction was found to be different from that observed in the rigor state.

Actins↗
PubMed1985

Factors influencing postexposure immunoprophylaxis of hepatitis B virus infection with hepatitis B immune globulin. High deoxyribonucleic acid polymerase activity in the inocula of unsuccessful cases.

Hepatitis B immune globulin was given intramuscularly to 102 staff members of a dialysis unit within 48 h after the accidental needlestick exposure to blood containing hepatitis B surface antigen (HBsAg). Hepatitis B virus (HBV) infection developed in 11 of 56 persons (20%) who had been exposed to blood containing hepatitis B e antigen (HBeAg). Among 56 HBeAg-positive inocula, HBsAg-associated deoxyribonucleic acid polymerase activity in the 11 inocula that transmitted HBV infection was significantly higher than that in the remaining 45 inocula that did not (log counts per minute 3.27 +/- 0.57 vs. 2.09 +/- 1.19, p less than 0.001). These 11 HBeAg-positive inocula revealed higher hemagglutination titers of HBsAg (geometric mean 13.5 +/- 1.4 vs. 11.2 +/- 3.2, p less than 0.001). The receptor for polymerized human serum albumin was detected significantly more often in the inocula that transmitted HBV infection than those that did not (10/11 vs. 24/45, p less than 0.05). Based on the results obtained, the failure in protecting all of those exposed to HBeAg-positive blood would be attributable to a high concentration of HBV in some HBeAg-positive inocula and the inability of intramuscular injection to raise a protective level of antibody in the circulation immediately.

DNA-Directed DNA Polymerase↗
PubMed1985

Specific receptor binding of atrial natriuretic peptide to rat renal cortex.

Radiolabeled receptor assay (RRA) of atrial natriuretic peptide (ANP) was studied in rat kidney membranes. Binding of [125I]-ANP to membrane preparations of rat whole kidney was saturated and show a high affinity (Kd = 0.51 nM). Furthermore, renal cortex membrane had a higher affinity for ANP binding site (Kd = 0.26 nM) than renal medulla membrane (Kd greater than 100 nM). This high affinity ANP receptor site in renal cortex membrane indicated that ANP controlled the balance of water and sodium excretion due to this receptor site in the kidney.

Animals↗
PubMed1985

Reduction of specific arginine-vasopressin binding sites of renal medulla membranes in lithium treated rats.

To elucidate the early effects of lithium treatment on the kidney, arginine-vasopressin (AVP) binding sites in the renal medulla were measured by radiolabeled receptor assay (RRA) in rats injected intraperitoneally with lithium chloride (4 mmol/kg body weight) for 7 days. After the 8th day, urine volume of rats injected lithium (Li group) increased and was significantly larger than that of the control rats that were injected physiological saline (control group). On the same day, the AVP binding capacities of renal medulla membranes of the Li group (Bmax = 28.9 +/- 7.2 fmol/100 micrograms protein) were significantly lower than that of the control group (Bmax = 50.0 +/- 6.3 fmol/100 micrograms protein), but there was no difference in the dissociation constant between the two groups. Our findings suggested that lithium-induced diabetes insipidus was due to a reduction in the number of AVP binding sites in the kidney.

Animals↗