Search PubMed⌕ Search

Biomedical subjects

T Mitsui

Publications and source records attributed to T Mitsui.

At least 289 records · Page 16Linked to original sources
PubMed1990

[Clinical usefulness of scintigraphy with 99m technetium phosphates in rhabdomyolysis].

We performed bone scans with 99mTechnetium phosphates in 15 cases of clinically suspected rhabdomyolysis admitted to Chigasaki Tokushukai Hospital. Whole body scans were performed within 5 days from the onset of illness or admission. Accumulation of the radioactivity in the skeletal muscle was revealed in 13 of the 15 cases and the involved muscle groups were visualized vividly. Etiologies of rhabdomyolysis were diverse, ranging from malignant syndrome to sepsis. Myocardial concentration was absent in all of the cases. Renal concentration of the isotope was seen in cases where the degree of rhabdomyolysis was higher and renal impairment was present. We conclude that 99mTechnetium phosphate bone scan is useful in clinically suspected rhabdomyolysis as a diagnostic test and as a test to localize and quantitate the muscular involvement.

Adult↗
PubMed1989

Combined hepatitis B immune globulin and vaccine for postexposure prophylaxis of accidental hepatitis B virus infection in hemodialysis staff members: comparison with immune globulin without vaccine in historical controls.

Twenty-three staff members serving in a hemodialysis unit were exposed accidentally to needlestick contaminated with blood containing hepatitis B surface antigen and hepatitis B e antigen, as well as high levels of DNA polymerase activity (greater than 100 cpm). They received hepatitis B vaccine (20 micrograms) simultaneously with hepatitis B immune globulin (5 ml, 200 IU per ml) within 48 hr after the exposure, and the vaccination was repeated at 1 and 3 months. The protective efficacy was compared with that in a past study in the same unit in which 33 members were given hepatitis B immune globulin alone within 48 hr after the exposure to blood with similarly high levels of DNA polymerase activity. No differences were noted in age or sex between the staff members who were vaccinated and those who were not, nor were there any differences between their inocula in the titers of hepatitis B virus markers. During 12 months after the accident, only one (4%) of the 23 vaccinated members contracted hepatitis B virus infection, at a frequency significantly lower than 11 (33%) of the 33 members who did not receive vaccine (p less than 0.02). These results indicate that hepatitis B vaccine, when given in combination with hepatitis B immune globulin, is efficacious for postexposure immunoprophylaxis of accidental infection.

Adult↗
PubMed1989

[An unresectable gastric cancer radically resectable following UFT, ADM, MMC therapy].

A 58-year-old woman who was inoperable because of S3 (pancreas and colon) and P1 at the initial operation was treated with UFT, ADM and MMC at a dosage of 242.7 g, 418 mg and 166 mg, respectively. After the chemotherapy (2 years and 6 months from initial operation), a second look operation revealed that a tumor was localized in the submucosal layer and there were no lymph node metastases. Thus, it could be resected radically. Until now, various methods of chemotherapy for unresectable gastric cancer have been reported, and many cases of CR contained fluoropyrimidine derivates. In the case under study, combination chemotherapy containing UFT was performed with good results.

Adenocarcinoma↗
PubMed1989

Localization of alpha 1-adrenoceptor in the rat kidney: in vitro autoradiography using [3H]-bunazosin.

We studied the precise localization of alpha 1-adrenoceptor in the rat kidney using in vitro macro- and micro-autoradiography (ARG) of [3H]-bunazosin. The slide-mounted nonfixed frozen sections (10 micron) of kidney were incubated with [3H]-bunazosin (5 nM) at 24 degrees C for 45 min, and then applied to macro- and micro-ARG. The macro-ARG revealed that the bunazosin binding sites were present mainly in the rat renal cortex. These bindings were evaluated to be specific by means of computerized image analysis system (RAS 1,000) of ARG. Micro-autoradiogram showed that the tubules in the renal cortex had higher specific grain density than the glomeruli. These findings suggested that alpha 1-adrenoceptor in the rat kidney located mainly on the cortical tubules.

Adrenergic alpha-Antagonists↗
PubMed1989

[Effects of the site of distal anastomosis on the branch flow of coronary arteries in an A-C bypass grafting].

Hemodynamics of coronary branch with retrograde blood flow of the host artery was examined in seven mongrel dogs, when the distal side of the graft was anastomosed at distal site to branching point in A-C bypass grafting. A Y-shaped tube was interposed to reconstruct coronary blood flow between the right carotid artery and the left anterior descending coronary artery (LAD), its one arm of Y was connected to proximal site of the branching point of the first diagonal artery (proximal anastomosis), and the other arm was connected to distal site of the branching point (distal anastomosis). After the LAD was ligated just distal to the bifurcation from the left main coronary artery, each arm was clamped in turn, and blood flow of the first diagonal branch was evaluated. Heart rate, left ventricular pressure and cardiac output (cardiac function), and blood pressure, flow and resistance of the interposed tube (bypass function) were not changed significantly in each arm clamped. The diagonal branch flow decreased from 11.2 +/- 2.7 ml/min (mean +/- S.D.) in proximal anastomosis to 10.3 +/- 3.1 ml/min in distal anastomosis with significant difference (P less than 0.05). The diagonal branch/bypass graft flow ratio decreased from 0.422 +/- 0.159 in proximal anastomosis to 0.395 +/- 0.160 in distal anastomosis with significant difference (p less than 0.05). The blood flow in systolic phase of the diagonal branch tended to increase in distal anastomosis as compared with proximal anastomosis. However, diastolic flow of the branch significantly decreased from 8.3 +/- 2.1 ml/min in proximal anastomosis to 7.1 +/- 2.2 ml/min in distal anastomosis (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1989

[The importance of aortic compliance as a prognostic factor after aortic valve replacement].

A variety of clinical variables and physiological parameters have been discussed in relation to postoperative survival and symptoms in aortic regurgitation (AR). Many of them have been derived from left ventricular morphology and functions, but there has been no parameter from aortic functions. As the heart is united with the aortic tree to form a circulatory system and both heart and aorta affect each other, aortic functions also have an important prognostic value after aortic valve replacement (AVR). This study was performed to clarify the participation of aortic functions in determining the prognosis after AVR. Fifteen consecutive patients undergoing isolated AVR for AR were evaluated. Twenty-one preoperative hemodynamic and dimensional variables of both heart and aorta were analyzed to determine the risk factors for early postoperative morbidity. These variables were obtained from chest X-ray film, electrocardiogram, echocardiogram, cine-aorto-ventriculogram and pressure manometries. All patients were divided in two groups according to the postoperative course. Group I composed of 10 patients took relatively smooth postoperative course, except two patients suffering from cardiac tamponade. Group II composed of 5 patients suffered from low cardiac output syndrome (LOS) and/or dangerous arrhythmias postoperatively. Two out of them died of uncontrollable ventricular arrhythmias. There were no statistic differences between two groups in the factors derived from preoperative examinations, i.e. CTR, LVDsI, PWT, R/Th, %FS, EDVI, EF, CI, LVEDP, etc. Mean aortic compliance of group II, (3.8 +/- 2.1) X 10(-4) mmHg-1, was, however, significantly lower than that of group I, (21.7 +/- 4.8) X 10(-4) mmHg-1, (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Bronchiolo-fiberscopic, histological and ultrastructural studies of peripheral lung tissues in bronchial asthma patients].

Bronchiolar findings in B8 and 9 of the right lung were taken with a BF-1. 8T bronchiolo-fiberscope in a total of 11 patients with bronchial asthma (6 male, 5 female, average age 59 years). In these patients air pollution was considered responsible for bronchial asthma. Approximately one month after the bronchoscopic examination, transbronchial lung biopsies were performed in the same portion of the lung. Histological and electron microscopic findings were correlated with the above results. Abundant secretion of a serous nature was constantly noted in the peripheral airways of each patient, which was consistent with the histological finding of goblet cell hyperplasia. Dark greenish pigmentation over the edematous mucosa was identified as anthracotic pigments, with or without iron deposit in the tissues. All patients showed occasional aggregates of alveolar macrophages with various amounts of carbon-mixed mineral dusts in their cytoplasm. Six of them formed in the alveolar interstitium micro-granuloma which consisted of epithelioid cells and multinucleated giant cells. These monocyte-derived cells were obviously adherent to one another by development of paired or unpaired subplasmallemmal linear densities along their cell membranes. Nine patients showed regeneration of bronchiolar cuboidal and type II alveolar epithelial cells along the proximal alveolar sacs. They frequently showed nuclear inclusions. This proliferative tendency is suggestive of previous bronchiolo-alveolar damage due possibly to the air pollutants in these patients.

Adult↗
PubMed1989

[Brain abscess following intracerebral hematoma].

A 53-year-old man fully conscious was admitted with lt. hemiparesis due to a rt. putaminal hemorrhage. A phlebitis of superficial vein at lt. leg was noted on the 7th hospital day. Following administration of antibiotics, he was afebrile three days after. But local inflammation of phlebitis and leukocytosis continued for over one week. He had no sign of infection thereafter. Four months later, the hemiparesis exacerbated. CT scan revealed a cystic lesion with ring-like enhancement at the site of the hematoma. He was afebrile and had no sign of meningeal irritation. The patient underwent a stereotaxic aspiration of brown turbid pus. The culture from the aspirate was positive for staphylococcus, and histopathological examination of the excised specimen demonstrated a brain abscess with hemosiderin deposits. Follow-up CT scan revealed a progressive diminution in the size of the abs cess. We felt the hematoma represented an area of locus minoris resistentiae and that bacterial seeding of the hematoma from phlebitis resulted in brain abscess formation. Brain abscess formation should be considered as having possibly developed in patients with clinical deterioration after cerebral vascular disease.

Basal Ganglia Diseases↗
PubMed1989

[A papillary-cystic neoplasm of the pancreas, a calcifying-inverted variant].

A calcifying-inverted variant of a papillary-cystic neoplasm (PCN) is reported, presenting presented the same histological and cellular features, and similar immunohistochemical characteristics and the ultrastructure of a papillary-cystic neoplasm of the pancreas (PCN) that usually afflicts younger women. It took the form of a partiality of a capsule, a common trait for a PCN, and proliferated on infiltrating the pancreatic parenchyma. The case involves a 51-year-old woman, whose PCN was detected by an abdominal X-ray that showed a calcified shadow in a health examination, though there was no palpable abdominal tumor. Usually, a PCN is detected by palpation tumor. Thus, the author demonstrates the existence of PCN variants, characterized by intrapancreatic infiltrating proliferation and an incomplete cyst formation or intratumoral calcified foci, and reports on variants of the usual PCN.

Calcinosis↗
PubMed1989

[Different characteristics of 123I-IMP SPECT images of cerebral embolism and cerebral thrombosis].

We performed 123I-IMP SPECT in patients with cerebral infarction within 48 hours after onset, to investigate its usefulness in differentiating cerebral embolism from thrombosis. Clearcut wedge-shaped defect was seen on the SPECT image in all six cases of clinically suspected cerebral embolism in our series, while this pattern was not observed among the five cases of cerebral thrombosis.

Adult↗
PubMed1988

A self-induced translation model of myosin head motion in contracting muscle. I. Force-velocity relation and energy liberation.

In our previous model, it was assumed that the two heads of myosin act co-operatively in producing force for the sliding of actin filaments relative to myosin filaments. We eliminate the assumption of co-operativity in the present model, following the conclusion by Harada and co-workers that a co-operative interaction between the two heads of myosin is not essential in producing actin filament movement. We assume that (1) a myosin head activated by ATP hydrolysis binds to the thin filament at a definite angle and does not do the power stroke, i.e. does not change its orientation during attachment, (2) a potential of force acting on the myosin head is induced around the thin filament when an ATP-activated myosin head binds to an actin molecule in the thin filament, and (3) the potential remains for a while after detachment of the myosin head and statistically controls the direction of thermal motion of the myosin head, so that the myosin head translates toward the Z-line as a statistical average. We did calculations on these assumptions with a mean tension approximation and got the following results. (a) The calculated force-velocity relation in muscle contraction is in fairly good agreement with experimental observation, including the give phenomenon that lengthening velocity becomes very large for a force about twice the isometric tension. (b) The calculated rate of energy liberation during muscle contraction as a function of load on muscle is in good agreement with experimental results. (c) The calculated distance over which a myosin molecule moves along the thin filament during one ATP hydrolysis can be more than 60 nm under unloaded conditions.

Energy Metabolism↗
PubMed1988

Localization of receptors for atrial natriuretic polypeptide (ANP) in the glomerulus: in vitro electron microscopic autoradiographical investigation using 125I-labeled ANP.

The localization of receptors for atrial natriuretic polypeptide (ANP) in the glomerulus of the rat was studied by electron microscopic autoradiography using 125I-labeled ANP. A total of 1,134 silver grains counted in 30 glomeruli were distributed as follows: processes of the podocytes (36.4%), cell bodies of the podocytes (14.8%), basement membrane (12.3%), endothelial cells (6.3%), mesangial cells (7.7%) and others, for example the vascular spaces (22.5%). This finding indicates that ANP binding sites are mainly localized on the foot processes of the podocytes in the glomerulus.

Animals↗
PubMed1988

Notes on the peroxidase activity of human basophil leukocytes.

In recent years, basophils have been described as peroxidase-positive in some textbooks (6, 8). However, as far as basophils in the peripheral blood from healthy persons are concerned, they must be considered as peroxidase-negative. This discrepancy is thought to be based on the following points: 1) fixation of human basophils is more difficult than that of the other leukocytes; 2) counterstaining with a certain basic dye causes misinterpretation of the enzyme reaction; 3) diaminobenzidine which has been most frequently used as hydrogen donor in the peroxidase reaction is so sensitive to non-enzymatic substances that substrate-minus experiments as well as inhibition experiments for peroxidase are absolutely necessary; and 4) basophils in the peripheral blood from healthy persons are originally peroxidase-negative. On the other hand, basophils in the peripheral blood from patients with myeloid leukemia are frequently peroxidase-positive, and yet, the peroxidase demonstrated in such basophils is not true myeloperoxidase since peroxidase from the above patients is resistant to heating, methanol and other chemicals known as inhibitors of myeloperoxidase. These data are illustrated by many color photographs.

Basophils↗
PubMed1988

Properties of [3H]bunazosin binding in rat kidney.

Properties of alpha 1-adrenoceptor binding in the renal cortex of rats were studied with [3H]bunazosin as the radiolabeled ligand. Both temperature and incubation time influenced bunazosin receptor binding. Subcellular distribution of [3H]-bunazosin binding revealed that the membrane fraction (30,000 x g pellet) had the largest proportion of total binding sites. Pretreatment of membrane preparation at 56 degrees C for 30 minutes greatly decreased the specific binding of [3H]-bunazosin, though there was no significant effect of the pretreatment at 24 degrees C and 37 degrees C for 30 minutes. Among various cations, some divalent ions such as Cu++ and Zn++ greatly decreased bunazosin binding, whereas monovalent ions had no effect on specific binding. Results of Scatchard analysis suggested that the rat renal cortex membrane has single binding sites with an apparent dissociation constant of 0.38 +/- 0.06 nmol/L, though the rat medulla membrane has no potent binding activity with bunazosin. The displacement study revealed that various adrenergic agents inhibit [3H]bunazosin binding in dose-dependent fashion; the rank order of potencies was bunazosin prazosin > phentolamine >> dl-norepinephrine > clonidine, yohimbine >> pindolol, propranolol. These findings reveal that bunazosin has specific receptor binding in the rat renal cortex, indicating that alpha 1-adrenoceptors exist in the rat renal cortex.

Adrenergic alpha-Antagonists↗