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Biomedical subjects

T Miller

Publications and source records attributed to T Miller.

At least 307 records · Page 17Linked to original sources
PubMed1978

99m technetium sulphur colloid localization in renal infection. An experimental evaluation.

Renal uptake of 99mTechnetium sulphur colloid (99mTcSC) was investigated in 99 animals with experimentally induced unilateral pyelonephritis and in 60 animals with a thermally induced renal injury. The degree of localization of 99mTcSC in the kidney was determined by direct counting of retained isotope after bilateral nephrectomy at autopsy. Phagocytosis of 99mTcSC by inflammatory tissue has been reported and it was anticipated that renal infection would lead to an increase in 99mTcSC uptake by the kidney. In fact it was found that renal infection with pathologic changes resulted in a significant decrease in the localization of 99mTcSC in the pyelonephritic kidney. A similar decrease was found in the thermally injured kidney but renal infection without pathologic changes did not give rise to any changes in radionuclide uptake. These findings suggested that phagocytosis by the proximal convoluted tubular cells is the normal mechanism for 99mTcSC accumulation in the kidney and that renal infection reduced the phagocytic capability of these cells.

Animals↗
PubMed1977

Intermittent dislocation of the liver. A syndrome associated with volvulus of the transverse colon and stomach and obstructive jaundice.

Displacement of the right lobe of the liver into the left upper abdominal quadrant can occur only if the diaphragmatic attachments are congenitally absent or traumatically disrupted. To our knowledge, the former situation has not been previously described in an adult patient. A young man with a lifelong history of unexplained intermittent, bizarre upper abdominal pain was found to have a freely movable right lobe of the liver that was attached only to the inferior vena cava. When this lobe was intermittently displaced into the left upper abdomen, volvuli of both the stomach and transverse colon developed. Stretching and tension of the common bile duct on the round ligament resulted in intermittent jaundice. At operation, these findings were confirmed, and the right liver lobe was secured to the diaphragm in its normal position. In addition, the mesenteric attachments of the liver, stomach, and colon were plicated. The patient has had complete relief of all symptoms for the two years since his operation.

Adult↗
PubMed1977

Effects of spontaneous and artificial membrane rupture in labour upon fetal heart rate.

This study reports the effects of spontaneous rupture of membranes and artificial rupture of membranes on fetal heart rate patterns during labour in 87 normal and 25 complicated pregnancies. The incidence of early deceleration patterns following membrane rupture was 6.25 per cent during the first 15 minutes and 1.78 per cent after 45 minutes, regardless of whether the pregnancy was normal or complicated. It is concluded that rupture of membranes does not significantly increase the incidence of early deceleration patterns. However, the occurrence of other heart rate alterations such as late decelerations, loss of beat-to-beat variability, changes in base line and tachycardia, need to be investigated further in larger collaborative studies.

Extraembryonic Membranes↗
PubMed1976

Studies on the neuropharmacological activity of bicuculline and related compounds.

Bicuculline and 3 chemical derivatives were assayed on a variety of biological systems. Consistent with reports of studies on other animals, some of these compounds caused convulsions in insects and blocked inhibitory postsynaptic potentials in insect muscle. They all potently inhibited mouse brain acetylcholinesterase. Bicuculline and its analogs inhibited the binding of GABA in vitro to sites in crayfish muscle membranes which have properties of receptor sites; this site of action could explain the activity of bicuculline at arthropod neuromuscular junctions. These compounds, at high concentrations (over 100 muM), also inhibited GABA uptake by mouse brain homogenates at 0 degrees C apparently non-competitively. Bicucine methyl ester inhibited GABA transport by brain at 37 degrees C, consistent with non-specific membrane effects at high concentrations of drug. These and other observations cast doubt upon the specificity of bicuculline-like compounds for action on GABA synapses, especially for in vitro studies at high drug concentrations (over 10 muM). The neuroactivity of low doses of bicuculline is apparently not explained by these in vitro effects, and could very well be due to inhibition of GABA synapses at either receptor or ionophore sites. At physiological conditions of pH and temperature, bicuculline is hydrolyzed at its lactone moiety to the less active compound bicucine; this could lead to underestimates of the biological activity of bicuculline. More stable analogs studied so far are not more potent, however.

Acetylcholinesterase↗
PubMed1976

Nasal glioma.

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Adolescent↗
PubMed1975

Surgical repair of facial nerve branches. An analysis of different sheathing and suturing techniques.

The distal branches of the facial nerve are sometimes severed in various forms of trauma. These distal branches respond to repair differently than do the main trunk or other peripheral nerves. Actual axon counts must be done to determine the percentage of regrowth rather than measuring nerve diameter. Physiologic and histologic techniques were used to analyze sheathing and suturing techniques in the repair of facial nerve branches in rabbits. Repair sites were examined at various intervals up to four months after repair. Very small suture material (10-0) must be used. Vein sheaths caused decreased axon regrowth, and strictures occurred when silicone elastomer sheaths were used. Seven stitches provided the best results in terms of axon regrowth, prevention of neuromas, and return of function. Three sutures or a continuous stitch produced poorer overall results.

Animals↗
PubMed1975

Selective deficiency of thymus-derived lymphocytes in experimental pyelonephritis.

Pyelonephritis was induced in experimental animals derived of thymus-derived (T) lymphocytes by adult thymectomy and serial sublethal irradiation. In this model T lymphocytes were reduced to less than 1% of normal adjudged by the in vitro Phytohemagglutinin (PHA) responsiveness of lymphoid cells from deprived animals compared with control animals. Pathologic, bacteriologic and immunologic aspects of renal infection were studied in the T cell-deprived animals during the acute, resolving and chronic stages of pyelonephritis. The experiments have shown that the ablation of lymphocytes did not appreciably alter the course of the disease.

Animals↗
PubMed1975

Water and electrolyte replacement during repeated days of work in the heat.

In an attempt to determine the value of replacing sweat losses with and electrolyte solution, 12 subjects (2 women and 10 men) were dehydrated (minus 3% body weight) on 5 successive days. During one 5-d sequence, the subjects replaced fluid losses with a glucose-electrolyte solution, while water was the only fluid ingested during a second 5-d series. With the exception of the drink, daily ionic and caloric intakes were identical for the two 5-d conditions. Measurements of water and electrolyte losses in sweat and urine showed a positive balance in body Na+, K+, and Cl- during both the water (W) and electrolyte solution (ES) treatments. Subjects accumulated significantly more Na+ during the W experiments (392 mEq/5 d) than when the electrolyte solution was ingested (334 mEq/5 d). As a result, the extracellular fluid compartment, represented by plasma volume, increased 12.2 and 9.0% during the 5-d sequence of the W and ES trials, respectively. It was concluded that the addition of electrolytes to drinking water is of minimal value for subjects who dehydrated (-3%) on repeated days and are permitted to ingest food and drink libitum

Aged↗
PubMed1975

Determination of glomerular filtration rate in the rat using 51Cr-EDTA and a single blood sample.

51Cr-labeled ethylenediaminetetraacetic acid (EDTA) was used to measure the glomerular filtration rate in rats using external body counting and a two-compartmental analysis according to the method of Sapirstein. A comparison was made of results calculated using the two-compartment method and a recently proposed formula requiring a knowledge of the distribution volume of the isotope and the analysis of a single timed plasma sample. The results have shown that the formula of Bryan et al. can be used for the rapid and convenient determination of glomerular filtration rate in small animals after the administration of 51Cr-EDTA.

Animals↗