Biomedical subjects
Publications and source records attributed to T Miki.
A unique chondrosarcoma developed in the distal right middle phalangeal bone of the foot in a 38-year-old woman. In a review of statistics on the localization of 264 chondrosarcomas in the Bone Tumor Registry of Japan since 1964, 4 were in the foot and 11 were in the hand.
A case of bilateral pheochromocytoma with an associated pancreatic islet cell tumor is reported. Prominent calcification was noted in the left adrenal tumor.
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Several experiments were performed using B/W mice, experimental model of human systemic lupus crythematosus, with a view to explore the pathogenesis of autoimmune diseases. As a result of the Investigation by the immunocyte adherence method, autoantibody-producing cells were demonstrated at a ration of 1 to 4% in the spleen, thymus and lymph nodes of B/W mice, but nearly absent in the bone marrow. B/W mouse lymphocytes showed the cytotoxic activity to allgeneic target cells (L cells), but ANA positive sera from B/W mice also had a remarkable cytotoxic activity in the presence of the complement of a high concentration. It was also disclosed that there are Ig+ and theta-lymphocytes in the B/W mouse thymus at a nearly equal percentage, and the possible identity of the two was suggested.
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Histophysiology, ultrastructure, chemical analyses of transplants and implants of Dunn and Ridgway mouse osteosarcomas demonstrate that tumorigenesis is a manifestation of deranged morphogenesis in developing mesenchymal cell populations. The end product of development is defective, incompletely calcified, disorganized bone without any inclusions of bone marrow tissue. When Dunn osteosarcoma is freeze-dried and then implanted, the tumor is resorbed and replaced by deposits of normal cartilage, bone, and bone marrow. Freeze-dried Ridgway osteosarcoma is replaced only by a fibrous connective tissue scar. Disaggregated Dunn tumor osteoblasts synthesize a trypsin-labile collagenase-resistant cell surface localized bone morphogen. Tumor matrix stroma, prepared by sequential chemical extraction of soluble non-collagenous proteins also contains significant quantities of the same bone morphogen. Tumor tissue pulverized to particle size as small as 44 micrometer3 transmitted bone morphogen more rapidly than intact tumor tissue. The total tumor cell and stroma mediated bone morphogen produces three times more normal bone than normal cortical bone matrix. Our working hypothesis is that a normal bone morphogenetic polypeptide (BMP) is synthesized by Dunn osteosarcoma cells and retained by the tumor matrix stroma. Neither the mechanism of transmission nor the mesenchymal cell receptor sites of BMP are known.
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Concanavalin A (Con A) concentration dependence of agglutinability of a mutant of Rous sarcoma virus which is temperature-sensitive for transformation was examined. Con A agglutinability of the virion was quantitatively expressed by measuring radioactivities of 60 to 70 S RNA extracted from Con A-agglutinated material. The mutant grown at a permissive temperature (35 degrees C) agglutinated at a significantly lower concentration of Con A, compared with that at a non-permissive temperature (40 degrees C).
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