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Biomedical subjects

T Miki

Publications and source records attributed to T Miki.

At least 811 records · Page 45Linked to original sources
PubMed1989

[Multidisciplinary treatment of advanced testicular tumors].

Present status and problems of multidisciplinary treatment for advanced testicular tumors were reviewed. In this paper, we presented the treatment results of 69 patients with advanced testicular cancer treated by multidisciplinary treatment. The primary PVB therapy induced a CR in 39 patients (56.5%), and 8 patients of them relapsed. After primary chemotherapy 40 patients, incomplete responders and relapsed cases, underwent salvage therapy. Salvage chemotherapy with CDDP and VM-26 or VP-16 was performed in 19 patients, and induced a CR in 10 (58.5%). Salvage surgery was done in 29, and produced NED in 22 patients (75.9%). As overall results of salvage therapy, 25 of 40 patients are living with NED, 3 are alive with tumors, and 12 patients died of the disease. As final results of the multidisciplinary treatment, of 69 patients with advanced testicular tumors 48 patients are living with NED and 3 patients with tumors, and 18 patients died of the disease. A overall cure rate was 73.9%. The overall 8-year survival rates of the 69 patients was 70.5%. The survival rate of 39 CR-patients, 23 PRs and 7 NRs was 94.9%, 45.7% and 0% at 4 years, respectively. The 8-year survival rates according to clinical stage for the last 10 years were 100% in stage I, 74.0% in stage II, and 70% in stage III. The survival rates for 10 years from 1968 to 1978 were 88.3% in stage I. 60% in stage II, and 33.3% in stage III. The treatment results were so satisfactory. To reach the treatment goal for advanced testicular tumors, importance of aggressive multidisciplinary treatment was emphasized.

Adolescent↗
PubMed1989

[Clinical evaluation of chemotherapy in urologic cancer].

In this paper, we will attempt to place the current status of the chemotherapy for testicular cancer, urothelial tumors and penile cancer in perspective. Perhaps the most exciting development in the past decade has been the demonstration of a significant number of complete responders (CR) to CDDP combined chemotherapy in patients with advanced testicular cancers. A CR rate of 60% was observed in the PVB therapy or VAB-6 therapy and no evidence of disease (NED) increased to 80% with salvage therapy. In our study of 43 evaluable patients, the CR rate was 60% and the NED rate was 81%. The activity of salvage chemotherapy with VP-16 for refractory testicular cancer has been well known with a CR rate of 19-38%. Among 13 evaluable patients with refractory cases, the CR rate was 46% with VP-16 or VM-26 salvage chemotherapy. The chemotherapeutic results of advanced urothelial cancers were also reviewed. In the present time, M-VAC therapy is thought to be the most effective regimen with a CR rate of 37%. In the chemotherapy of the primary lesion of penile cancer, bleomycin is most effective with a response rate of 60-70%. But for the primary lesion, there has been no effective chemotherapy.

Adult↗
PubMed1989

[Caries-inducing activity of isomaltooligosugar (IMOS) in in vitro and rat experiments].

The caries-inducing activity of Isomaltooligosugar (IMOS: a isomaltose rich sugar mixture) was examined in in vitro and in vivo experiments. Strains of Streptococcus mutans MT8148R and Streptococcus sobrinus 6715 fermented IMOS and produced acids. IMOS inhibited the glucan synthesis from sucrose by glucosyltransferases from both of S. mutans and S. sobrinus. Furthermore, IMOS inhibited sucrose-dependent adherence of those mutans streptococci. IMOS was found to induce significant but minimal caries SPF Sprague-Dawley rats infected with either MT8148R and 6715. However, IMOS did not inhibit the caries which was induced by sucrose.

Animals↗
PubMed1989

[Detection of retinal vascular endothelial damage by fluorescein isothiocyanate-labelled platelet].

Fluorescein isothiocyanate (FITC)-labelled platelets were prepared in Sprague Dawley rats, and brought back into the rat through their femoral veins. Their ability to detect the photocoagulation-induced damage in the occluded retinal vessels was examined by epifluorescence microscopy in whole mount retinal specimens and cryostat specimens. The photocoagulation effects on the major retinal vessels by yellow dye (577 nm) and orange red (600 nm) laser, with parameters of 100 mu, 0.05 sec, 70 m W and 3 exposures were compared. The occluded vessels showed extensive accumulation of labelled platelets in the specimens. The portions photocoagulated by the yellow laser also showed accumulation, but not those by the orange red laser. This difference was considered to be due to the difference of hemoglobin absorption at each wavelength.

Animals↗
PubMed1989

[A case of exohepatic pedunculated hepatocellular carcinoma suspected of adrenal tumor].

A case of exohepatic pedunculated hepatocellular carcinoma that was clinically diagnosed as nonfunctioning adrenal tumor is reported. A 66-year-old man was admitted to our hospital for further examination of unstable angina pectoris. Abdominal echogram and CT scan revealed a large tumor in the right retroperitoneal space. Selective right renal arteriography demonstrated that the tumor was fed by the capsular branch of right renal artery and the right adrenal artery. Adrenal function was normal. Preoperative diagnosis of right nonfunctioning adrenal tumor was made. On operation we found that the tumor was pedunculated from the liver and adhered massively to both right kidney and vena cava. The tumor and right kidney were removed. A histopathological examination demonstrated well differentiated hepatocellular carcinoma (Edmondson's grade II type).

Adrenal Gland Neoplasms↗
PubMed1989

Allele loss on chromosome 10 and point mutation of ras oncogenes are infrequent in tumors of MEN 2A.

The multiple endocrine neoplasia type 2A (MEN 2A) gene has been mapped to the centromeric region of chromosome 10 by linkage analysis. We examined 36 medullary thyroid carcinomas (MTCs) (16 hereditary and 20 sporadic) and ten pheochromocytomas (eight hereditary and two sporadic) to detect loss of alleles on chromosome 10 using seven polymorphic DNA markers mapped to this chromosome. Of 20 informative cases, only one (5%) sporadic MTC showed loss of heterozygosity at the locus RBP3. Allele loss at the RBP3 locus was not found in pheochromocytomas from six heterozygotes. All tumors retained constitutional heterozygosity at six other loci on chromosome 10 (D10S17, D10S34, D10S24 on the short arm, D10S15 in the pericentromeric region, D10S20, and D10S4 on the long arm). Our findings suggest that the second hit for tumorigenesis in MEN 2A may not be loss of function of the normal allele at the homologous locus on the other copy of chromosome 10. Mutated ras oncogene was found only in one of 18 MTCs at the codon 61 of H-ras.

Adrenal Gland Neoplasms↗
PubMed1989

[Operative indication for aortic valvuloplasty by rasping procedure from the point of histopathologic evaluation].

Rasping procedure is proposed by the author as one of the methods of aortic valvuloplasty and defined as shaving the surface of rheumato-degenerative aortic valve by using the electric rasp. Materials were the removed rheumato-degenerative aortic valves as specimen, and classified into 3 groups. The first group (type I) was valve lesion limited to valve free edge, second (type II) was mild thickening entirely, third (type III) was severe thickening with calcified degeneration. Rasping procedure was performed for the thickened portion of the valve specimen by the electric rasp. Morphologic examinations after rasping procedure were evaluated by histopathologic study. Histopathologically, there was hyaline degenerative connective tissue in superficial layer above the collagen fiber's layer in rheumato-degenerative thickened valve in type I. This hyaline degenerative connective tissue was considered to be fragile and pathologic in the tissue structure. Rasping procedure could remove this connective tissue layer. Type II, there was the similar finding to the type I from the free edge to the mid portion of the cusp. So, Rasping procedure was effective for type I and type II valve degeneration. On the contrary, the calcified lesion (type III), rasping procedure was not effective in valve coaptation and the pathological findings showed the fragmentation in the calcified layer. In the pathological comparison with the slicing procedure for type II by the surgical knife, there was a crack and cleft in the collagen fiber's layer in the case of slicing procedure. It can be concluded the results of histopathological study of the rasping procedure proved to be superior to the conventional aortic valvuloplasty (slicing method).

Aortic Valve↗
PubMed1989

[The effect of melanin and hemoglobin on the dye laser photocoagulation in pigmented and albino rabbits].

Photocoagulation was performed in pigmented and albino rabbits using four different wave-lengths of the dye laser (577 nm, 590 nm, 610 nm and 630 nm), and each photocoagulated lesion was examined histologically. The 577 nm dye laser produced chorioretinal coagulation in albino rabbits, which was almost the same as that in pigmented rabbits. This result confirmed that the 577 nm dye laser was well absorbed by hemoglobin in the choriocapillaris, and could produce the sufficient coagulation even if there was no melanin pigment. The 590 nm dye laser produced chorioretinal coagulation in albino rabbits, but it was weaker than that in pigmented rabbits. It was considered that this was because the absorption by hemoglobin of the 590 nm dye laser was less than that of the 577 nm dye laser. The 610 and 630 nm dye laser could not yield appropriate coagulation in albino rabbits under the same conditions as in the 577 nm dye laser. More intense coagulation, that is longer duration and higher power, was required to make chorioretinal coagulation in albino rabbits using the 610 and 630 nm dye laser. In photocoagulation of normal fundus, melanin is the main substance of laser absorption, but in various disorders lacking melanin, the differences of the hemoglobin absorption rate becomes important.

Animals↗
PubMed1989

[Clinical statistics on inpatients and operations at the Department of Urology, the Center for Adult Diseases, Osaka, 1984-1988].

Statistical observation on inpatients and operations at our department between January 1984 and December 1988 revealed the following results: 1) The total number of inpatients was 1962 (male: 1658, female: 304). The most frequent diseases were bladder cancer (30.0%), benign prostatic hypertrophy (19.2%), prostatic cancer (10.6%) and renal cancer (6.7%). 2) The total number of operations was 1699. The most frequent operations were transurethral resection (TUR) of bladder tumor (22.8%), TUR prostate (20.7%), TUR biopsy (6.5%) and total cystectomy (5.4%).

Female↗
PubMed1989

Extraction of dislocated lenses using vitrectomy techniques.

In fourteen eyes in thirteen patients, dislocated lenses into the vitreous were extracted using the techniques of vitreous surgery. Our surgical techniques of the extraction, as well as the indication and the prognosis, were described in this paper. Techniques of the lens extraction were basically Barraquer's method, but in modified form. Vitrectomy was carried out by open sky approach (in 2 cases) or pars plana approach (in 12 cases). In cases complicated by acute phacolytic uveitis, excellent results were obtained by these surgical techniques after the complete control of inflammation with steroid. Before surgical extraction, intraocular pressure had been elevated over 21 mm Hg in eight cases. But in all these cases intraocular pressure was controlled without medication after surgery. Visual acuity was improved unless chorioretinal atrophy or glaucoma were not accompanied. From these surgical results, it seems to be reasonable to extract surgically the dislocated lens before the eye is severely damaged.

Adult↗
PubMed1989

[A case of primary ureteral squamous cell carcinoma associated with calculus].

A case of primary squamous cell carcinoma of the ureter associated with ureteral calculus is presented. A 66-year-old woman was admitted to our hospital, with the chief complaint of macroscopic hematuria in October, 1985. A kidney-ureter-bladder X-ray and drip intravenous pyelography failed to reveal the calculus shadow clearly. However, computerized tomographic scan revealed the calculus shadow clearly adjacent to the ureteral tumor, and retrograde pyelography revealed the filling defect on a third lower portion of the left ureter. She was diagnosed with tumor of the ureter associated with the calculus. She underwent complete nephroureterectomy with excision of a periureteral cuff of the bladder. The tumor was diagnosed histologically as squamous cell carcinoma. Metastases and recurrence of tumor have never occurred on July, 1987. Forty-four cases of the primary ureteral squamous cell carcinoma could be collected in the Japanese literature. Moreover, we deal with this disease associated with the ureteral calculus.

Aged↗
PubMed1989

[Coronary artery stenosis following aortic valve replacement--a case report].

A case with severe left main trunk (LMT) stenosis nine months after aortic valve replacement was presented. The patient, 57-year-old female, underwent aortic valve replacement with a tilting disk valve (Omnicarbon 21 A). Her postoperative course was uneventful, but angina pectoris developed after nine months. Coronary angiography was performed and revealed 99% LMT stenosis. Operation was performed with OTCA to LMT and with a saphenous vein graft to left anterior descending artery. Coronary artery stenosis following aortic valve replacement may be dangerous and it must be treated as soon as the diagnosis is established.

Aortic Valve↗
PubMed1989

Congenital soft-part chondroma. A case report.

A soft-part chondroma was found in the back of a new-born infant. The tumor was located in the soft tissue between the spinous processes of T12 and L1 and grew larger. It was successfully removed operatively at the age of two years. It was a completely encapsulated hyaline cartilagelike tumor, and the skeleton. Histologically, it consisted of a cartilaginous tissue with a lobular pattern, and nuclear atypia was found in some areas.

Back↗
PubMed1989

Morphological change and Raman spectrum of rabbit lens irradiated with ultraviolet laser beam.

The effect of ultraviolet rays on eyes was studied. An ultraviolet laser beam (XeCl 308 nm) was irradiated to rabbit eyes to investigate morphological changes of the lens fibers and molecular structural changes of the lens proteins at immediately, 15 days and 32 days after irradiation. 1. Scanning electron microscopic findings of the lens The lens fibers in the control eye were regularly and densely arranged in neat layers of hexahedrons. In the irradiated eye, the fibers at areas that seemed injured were disrupted and the disrupted ends were spherical-shaped. 2. Raman spectra of the lens 1) The relative intensity ratio (I825/I850) of the Raman scattering for the tyrosine residue and the relative intensity ratio (I3390/I2960) of the OH stretching mode (3390 cm-1) of water contained in the lens cortex showed slight changes in the irradiated eye compared to the control eye. 2) The relative intensity ratio (I2572/I2721) of the SH stretching mode (2572 cm-1) for the cysteine residue was 1.05 in the irradiated eye at 32 days after irradiation. It was lower than that in the control eye (1.22 +/- 0.08). This suggested the synthesis of S-S binding by oxidization.

Animals↗
PubMed1989

[Clinical evaluations of surgical treatment of infective endocarditis].

This paper shows the clinical evaluations of surgical and medical treatment of infective endocarditis (IE). IE occurred in 33 cases (10.1%) among 372 cases of valve replacement. Of all the 33 patients, IE was consisted of native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE). IE was evaluated as for the microorganism, complication, operative indication and operative mortality. At first, all of NVE underwent surgical treatment, active phase endocarditis 4 and healed endocarditis 14. Microorganism was streptococcus aureus in an overwhelming majority. Operative indications was congestive heart failure in almost all cases, next to vegetation and infection resistant to medical treatment. Operative mortality was 5.6% (1 out of 18 cases), which case was in the septic shock and cerebral bleeding prior to the surgical treatment. The others was satisfactory condition postoperatively. Next of PVE, PVE happened in 15 cases, in which there were 5 cases of bioprosthetic PVE and 10 cases of mechanical valve PVE. Microorganism for PVE was staphylococcus epidermidis in the major part (60%). Mortality in PVE was 53.3% (8 out of 15), but mechanical valve PVE was worse in prognosis than bioprosthetic PVE. Cerebral complications occurred in 3 cases of mechanical valve PVE, on the other hand there was no cerebral complication in bioprosthetic PVE. As for the hemodynamic change in PVE, mechanical valve PVE had the tendency to take the prompt or sudden deterioration of hemodynamics caused by endocarditis surrounding the suture ring, especially in mitral position, on the contrary hemodynamic deterioration was gradually proceeded in bioprosthetic PVE. UCG made much of the diagnosis of PVE, especially in mechanical valve PVE, in which cases endocarditis was recognized only surrounding the suture ring. PVE takes the miserable outcome in many cases, so carefully observation is necessary in order not to lose the timing of the surgical treatment.

Adult↗
PubMed1989

[Time-related degeneration of Carpentier-Edwards bioprosthesis in mitral position].

Carpentier-Edwards bioprostheses have been shown to provide a low incidence of valve-related complications, especially thromboembolism, but the durability has caused the serious concern. This report suggests that Carpentier-Edwards prostheses have been gradually degenerative, and stenotic degeneration and the year after operation are well correlative. In Osaka National Hospital, Carpentier-Edwards prostheses were implanted in 89 patients in mitral position from 1973 to 1981. Of all the patients, 50 patients were undertaken to single valve replacement in mitral position and could be followed up in our department. For a total of 50 patients, materials are 30 patients who could be detected by clinical findings, pulsed Doppler echocardiography, cardiac catheterization and soft X-ray evaluation in explanted prostheses at reoperation. Follow-up duration was ranged 4.2 to 12.1 years with a mean duration of 7.94 years. The age ranged from 32 to 71 years of age. The initial diagnosis of the time-related degeneration was the appearance of newly acoustic rumbiling murmur. Furthermore, regurgitant murmur, arrythmia (atrial fibrillation) and cardiac enlargement were followed in addition to rumbling murmur. The assess of the transmitral flow such as pressure half time and peak pressure gradient by pulsed Doppler echocardiography was the easy way to evaluated the time-related degeneration. Time-related stenotic change by pulsed Doppler was expressed as a linearized curve. At 6 years and below valve function seemed not to be impaired but stenotic dominant degeneration with the cusp tear was prominent beyond 7 years. Cardiac catheterization data could make sure of the pulsed Doppler findings by assessing mitral valve gradient and mitral valve area.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

1 alpha,25(OH)2D3 exerts cytostatic effects on murine osteosarcoma cells and enhances the cytocidal effects of anticancer drugs.

The effects of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3), 1 alpha-hydroxyvitamin D3 (1 alpha(OH)D3), and dexamethasone on colony formation of Dunn osteosarcoma cells (TA 102 cells) were investigated. Concentrations of 1 alpha,25(OH)2D3, 1 alpha(OH)D3, and dexamethasone at which they exerted 50% reduction of the total area of TA 102 colony formation were 9 X 10(-9) M, 9 X 10(-8) M, and 5 X 10(-6) M, respectively. Effects of anticancer drugs on TA 102 cells were also investigated and concentrations needed for 50% growth inhibition (50% inhibitory concentration values) of cis-platinum, mitomycin C (MMC), methotrexate (MTX), and Adriamycin (ADR) against TA 102 cells were calculated to be 0.07 microgram/ml, 0.0008 microgram/ml, 0.0008 microgram/ml, and 0.0005 microgram/ml, respectively. The simultaneous treatment of TA 102 cells with 10(-8) M of 1 alpha,25(OH)2D3 and anticancer drugs significantly enhanced the respective inhibitory effects on colony formation. In this treatment, the IC50 value of MMC was calculated to be 6.4 X 10(-6) micrograms/ml, which was 1/160 of the expected IC50 value of MMC (8 X 10(-4) micrograms/ml). Similar synergistic effects were observed when the cells were treated with 1 alpha,25(OH)2D3 and low concentrations of cis-platinum, MTX, or ADR.

Animals↗