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Biomedical subjects

T Mets

Publications and source records attributed to T Mets.

At least 37 records · Page 2Linked to original sources
PubMed1987

Treatment of bacillary dysentery: a comparison between enoxacin and nalidixic acid.

A prospective randomized study has been conducted in Rwanda to compare the efficacy of enoxacin versus nalidixic acid for the treatment of bacillary dysentery in adults. Seventeen patients received nalidixic acid and 21 received enoxacin. All isolates (37 shigella, 1 campylobacter) were sensitive in vitro to the two drugs. All patients showed a favourable clinical and bacteriological response and the results obtained with both drugs were comparable. Enoxacin seems to be a good alternative to nalidixic acid for bacillary dysentery due to multiresistant shigella.

Adult↗
PubMed1983

Similarity between in vitro and in vivo cellular aging.

In vivo and in vitro cellular aging were compared by determining the division capacity of individual, cloned cells of (1) the primary stromal population of human bone marrow, obtained from donors of various ages, and (2) the population at various passage levels of an in vitro subcultivated culture of the same origin. We find a strong similarity between the two series of data. This observation provides a further argument that cellular aging in vitro represents a biologically relevant phenomenon.

Adult↗
PubMed1981

Variations in the stromal cell population of human bone marrow during aging.

Age-related variations in the stromal cell population of human bone marrow were studied by means of a cloning assay. It was found that these cells are heterogeneous both in division capacity and in morphology. Fibroblast-like progenitor cells could be distinguished from epithelial-like cells, having only a very limited division potential. A significant inverse correlation between the donor age and the number of progenitor cells could be demonstrated. This loss of progenitor cells during aging was compensated by an increase in the number of epithelial-like cells.

Adolescent↗
PubMed1981

In vitro aging of human bone marrow derived stromal cells.

We have studied the in vitro cellular aging process in human bone marrow derived stromal cells. Two cell types, here called type I and type II, can be distinguished in the primary cell population. During subcultivation, resulting in aging in vitro, the type I cells gradually disappear, whereas the type II cells form an increasing fraction of the population. This observation is confirmed by cloning experiments, revealing that type I cells act as progenitor cells, giving rise to non-dividing type II cells. These results are best explained by the terminal differentiation theory as proposed by Martin et al.

Adult↗
PubMed1979

Sonically guided renal biopsy.

The results of 91 sonically guided renal biopsies are reported. In the 53 cases where renal size and function allowed other localization techniques, renal tissue was obtained in 100 percent and glomeruli in 88.6 percent. In 38 cases no other techniques could have been used because of poor renal function (serum creatinine greater than or equal to 4.0 mg/dl) and/or decreased renal size (less than or equal to 10 cm); in these biopsies renal tissue was obtained in 86.8 percent and glomeruli in 73.7 percent.

Biopsy, Needle↗