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Biomedical subjects

T Mayumi

Publications and source records attributed to T Mayumi.

At least 217 records · Page 12Linked to original sources
PubMed1983

Plasma concentrations of lidocaine associated with cervical, thoracic, and lumbar epidural anesthesia.

We measured arterial plasma concentrations of lidocaine by enzyme immunoassay when 10 ml of 2% lidocaine without epinephrine was injected into the cervical, thoracic, or lumbar epidural spaces in 30 patients. There was no difference in the time courses of plasma levels of lidocaine. Peak concentrations were achieved 10 min after injection and were similar regardless of the site of injection. These results indicate the absence of significant differences in the rate of vascular absorption of lidocaine from different parts of the epidural space.

Adult↗
PubMed1983

Baroreflex control of heart rate during cardiac sympathectomy by epidural anesthesia in lightly anesthetized humans.

To evaluate the effects of acute sympathetic denervation on the baroreflex control of heart rate, baroreflex sensitivities were compared in lightly anesthetized humans who had either cervical (N = 20) or lumbar epidural anesthesia (N = 18), or neither (N = 18). Levels of anesthesia during cervical block using 10 ml of 2% mepivacaine without epinephrine were C3-T7 and T7-S1 during lumbar epidural block. Baroreflex sensitivity was assessed with a pressor test using phenylephrine infusion to increase systolic blood pressure by 60 mm Hg within 2 min. There were no statistically significant differences in the baroreflex sensitivities in the absence of epidural block and during lumbar epidural block, the slopes of the regression line (in msec of RR interval change per mm Hg increase in systolic blood pressure, i.e., msec/mm Hg) relating systolic pressure and the succeeding pulse interval being 3.8 +/- 1.4 (mean +/- SD) and 3.7 +/- 1.7, respectively. The mean slope during cervical block, 1.1 +/- 1.2 msec/mm Hg, was significantly different from the slopes observed in the absence of epidural block and during lumbar epidural block (P less than 0.01). The results suggest that cardiac sympathectomy induced by epidural anesthesia can suppress partially baroreceptor function by interrupting sympathetic efferent fibers innervating the heart during high levels of epidural anesthesia, but that lumbar sympathectomy during epidural anesthesia is unlikely to affect baroreceptor activity.

Adult↗
PubMed1982

Circulatory responses to airway stimulation and cervical epidural blockade.

In order to investigate the effects of acute cardiac sympathectomy, the circulatory responses due to tracheal intubation and broncho-carinal stimulation were compared in lightly anesthetized, paralyzed patients who had either cervical (n = 18) or lumbar epidural blockade (n = 18), or neither (n = 12). The mean analgesic levels obtained using 2% mepivacaine with epinephrine were C4-T8 in the cervical group, and T7-S1 in the lumbar group. Increases in arterial blood pressure (AP) and heart rate (HR) due to laryngoscopy were significant (P less than 0.01) but similar in the three groups of patients. Broncho-carinal stimulation by a suction catheter did not produce noticeable changes in AP and HR in the cervical group; significant increases were observed in the other two groups (P less than 0.01). It was concluded from this study that acute sympathectomy induced in part by cervical or lumbar epidural block does not attentuate circulatory responses due to laryngoscopy and tracheal intubation. The cervical blockade, however, can prevent such responses due to broncho-carinal stimulation without predominant vagotonic reflexes; this may be attributed to the interruption of sympathetic afferents to the spinal cord at the epidural level.

Adult↗
PubMed1977

Androgen regulation of transferase II activity in the mouse kidney.

Castration of adult male mice reduced the ability of the transferase factors of the kidney to stimulate amino acid incorporation by polysomes in vitro. The administration of testosterone propionate (TP) to the mice for 11 days greatly increased the activity of the transferase fraction. The changes occurred only in transferase II. The induction of the increase in transferase activity was evident 24 h after the injection of TP and required a lag period of at least 12 h. The concentration of pH 5 enzymes (protein) was slightly decreased by castration and was restored by TP administration. The radioactivity in the hot perchloric acid extract of the protein after amino acid incorporation was increased but the activity of the pH 5 enzyme fraction on amino incorporation was not significantly changed by androgen administration.

Animals↗
PubMed1976

Detection of circulating carcinoembryonic antigen (CEA) by counter-immunoelectrophoresis.

A sensitive method is described for detecting circulating carcinoembryonic antigen (CEA) by combined use of counter-immunoelectrophoresis and intensifiers. Perchloric acid extraction of serum was followed by counter-immunoelectrophoresis against monospecific antiserum to CEA. A precipitin line formed was intensified further by electrophoretic binding of anti-gammaG gamma-globulin and Amido Black staining. Less than 10 ng CEA/ml was detectable. Using this method, a total of 84 sera from patients with or without malignancy was examined. The results obtained were in general agreement with those reported by radioimmunoassay. The method appears to be useful as a diagnostic aid, since it requires neither labeled preparations of purified CEA nor special equipment for assay.

Antigens, Neoplasm↗