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Biomedical subjects

T Maudelonde

Publications and source records attributed to T Maudelonde.

62 records · Page 4Linked to original sources
PubMed1984

[Pituitary adenoma secreting somatotropic hormone. Gigantism and peripheral neuropathy. A case].

Gigantism, an extremely rare condition, develops before puberty or in subjects in whom puberty is not yet completed. Hypersecretion of somatotropic hormone results in a tremendous surge in growth (our patient was 2.36 m tall). Among other clinical symptoms disabling peripheral neuropathy predominates and changes in nerve conduction velocity are not merely due to the increase in height. The increase in growth hormone concentrations combined with hypogonadotrophic hypogonadism with normal prolactinaemia is associated with peculiar cutaneous symptoms and with low levels of sex hormone-binding protein.

Adenoma↗
PubMed1983

[Glycosylated proteins and control of the diabetic: use of continuous flow insulin pumps by the subcutaneous route].

Ten insulin-dependent diabetic patients were controlled using a portable insulin pump (Pye Dynamic MS 16). They were studied for approximately 10 weeks. The responses of fasting blood glucose, glycosylated serum proteins and glycosylated hemoglobin were studied. Glycosylated serum proteins and glycosylated hemoglobin were measured a semi-automated colorimetric method. Although the fasting blood glucose decreased by about 45%, its variability underlines its limitation as a metabolic control parameter. Glycosylated hemoglobin decreased by 9% in the first week, and 21% by the tenth week. The glycosylated serum proteins decrease was 39% in the first week and 50% by the third week. Four insulin-dependent pregnant women had a similar but less rapid, decrease in the 3 variables compared to the other 6 cases. In all ten diabetics treatment lowered the 3 variables toward normal levels when compared to 73 insulin dependent diabetic patients using the classic method of daily insulin injections. The kinetic patterns of the 3 variables confirms the usefulness of glycosylated serum proteins which respond to altered levels of control more rapidly (10 days) than glycosylated hemoglobin. This is shown both by the response to improved control in insulin-dependent diabetics and secondly by their changes after insulinoma removal. The physiopathological significance of serum protein glycosylation is at present uncertain.

Adult↗
PubMed1982

[A detailed lipidograph: enzymatic determination of cholesterol, phospholipids and glycerides in plasma lipoprotein after a cellulose acetate electrophoretic procedure (author's transl)].

The specific determination of cholesterol and its evaluation in lipoproteins separated by cellulose acetate electrophoresis is described. Using this technique, the authors extended the specific lipid determinations to phospholipids and glycerides. The precision, linearity, accuracy of the methods are satisfactory for fractions greater than 10%. Phospholipids and cholesterol values in alpha lipoproteins are compared with those obtained in the supernatant by concanavalin A precipitation; the differences between the two methods are not significant. We suggest using these three enzymatic determinations to produce a detailed lipidograph. For a selected population, the lipid values in each fraction (expressed in g/l and in mmol/l) were close to those given in the literature. We compared our lipidograph, expressed in SI units, with the Oil Red O stained lipidograph; the difference was not significant.

Adult↗
PubMedDate not supplied

[Physiology and physiopathology of breast development in men].

Development of breasts in male subjects is a characteristic feature of gynecomastia, a not infrequent condition as it may be a physiological feature present at birth or developing during puberty and old age. The possibility of an underlying pathological process has always to be considered. Male breast enlargement may result from voluntary or involuntary ingestion of estrogens or medication possessing anti-androgenic activity. Pathological gynecomastia is due to either an excessive production of estrogens or a drop in the plasma T/E2 ratio, medical treatment is unsatisfactory, and mammectomy is required when esthetic considerations are of primary importance, after investigations to establish the etiology of the gynecomastia.

Alcoholism↗