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Biomedical subjects

T Matsuda

Publications and source records attributed to T Matsuda.

At least 1,621 records · Page 90Linked to original sources
PubMed1979

Increase of brain taurine contents of E1 mice by physiological stimulation.

We determined the effect of physiological stimulation on taurine contents in three regions (cerebral cortex, brain stem and cerebellum) of the brain of E1 mice, a genetically epileptic strain. Taurine contents in all regions of the brain increased significantly at the onset of convulsions, as induced by tossing the animals up many times. Levels in the cerebral cortex and cerebellum increased markedly in the early stage of the stimulation, yet convulsion did not occur. Taurine contents in the cerebral cortex and brain stem returned to the resting level with 30 min after the onset of convulsions, while levels in the cerebellum remained high for 3 hr. Concentration of taurine in the plasma also increased with the onset of convulsions. On the other hand, taurine administration increased the threshold of convulsion by the stimulation in E1 mice.

Animals↗
PubMed1979

Effect of aminophylline on regional perfusion distribution in the lungs.

Using ten normal dogs, the right upper lobe of the lung was isolated in vivo by a balloon catheter and was artificially ventilated with nitrogen, air, 60% oxygen in nitrogen, and 60% oxygen and 20% carbon dioxide in nitrogen, while the rest of the lungs maintained a spontaneous breathing of ambient air. Aminophylline did not show a vasodilating action under severe alveolar hypoxia (PAO2: ca. 40 mmHg); on the contrary, it seemed to potentiate hypoxic pulmonary vasoconstriction. When the regional alveolar oxygen tension became less hypoxic (PAO2: ca. 70 mmHg) or higher than that in the rest of the lungs which spontaneously breathed ambient air, aminophylline showed a definite vasodilating action. Aminophylline also showed a vasodilating action in alveolar hypercapnia in the presence of alveolar hyperoxia.

Aminophylline↗
PubMed1978

Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids.

Cyclic AMP phosphodiesterase (PDE) in membrane fraction from rat cerebral cortex was activated by Triton X-100, and treatment at alkaline pH and with phospholipase C. These results suggest that membrane PDE exists in a latent form and is influenced by microenvironmental changes within the membrane. Furthermore, the PDE, unlike soluble enzyme, is not influenced by a protein activator and Ca++.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1978

Possible role of intestinal alkaline phosphatase activity in thiamine transport.

Thiamine deficiency caused a marked decrease of intestinal alkaline phosphatase (al-Pase) activity, but had no effect on the Ca++-ATPase activity and Ca++-absorption in rats. The al-Pase activity was significantly decreased 1 h after oral administration of ethanol at 0.5 and 2.5 g/kg. In contrast, Mg++-, Ca++-and (Na+ + K+)-ATPase activities did not change after the administration of ethanol. These findings show that the al-Pase activity, unlike the Ca++-ATPase activity, is not related to Ca++-absorption. A possible role of al-Pase activity in the active transport of thiamine in the intestine was discussed.

Adenosine Triphosphatases↗