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T Matsubara

Publications and source records attributed to T Matsubara.

654 records · Page 37Linked to original sources
PubMedDate not supplied

The effect of N-(2-carboxyphenyl)-4-chloroantranilic acid disodium salt (CCA) on concanavalin A-induced superoxide anion release in human mononuclear phagocytes.

Superoxide anion (O2-), generated and released by mononuclear phagocytes (M phi), plays significant roles in tissue damage accompanying inflammatory and immunological reactions. N-(2-carboxyphenyl)-4-chloroantranilic acid disodium salt (CCA), is a newly synthesized immunomodulator for which therapeutic efficacy in the treatment of rheumatoid arthritis (RA) has been reported. In this investigation, we have examined the effect of CCA on concanavalin A (Con A)-induced O2- release in human M phi. Exposure of M phi to Con A induced a large increase of O2- release. Preincubation of M phi with CCA suppressed O2- release induced by Con A almost to a control level. On the contrary, CCA itself did not have a significant effect on basal O2- release from M phi. These results indicate that the inhibition of O2- release from activated M phi may be an important factor in the anti-inflammatory effects of this drug.

Anti-Inflammatory Agents↗
PubMedDate not supplied

The effects of gold sodium thiomalate on the binding and internalization of concanavalin A in human mononuclear phagocytes.

The effects of gold sodium thiomalate (GST) on the binding and internalization of concanavalin A (Con A) in human mononuclear phagocytes (M phi) were investigated in vitro. First, the binding and internalization of Con A were examined quantitatively using 3H-Con A. The prolonged incubation with GST induced a prominent inhibition of 3H-Con A internalization in M phi. The inhibition was increased in parallel with both increasing concentrations of GST and increasing time intervals of the incubation with GST. On the other hand, GST failed to significantly affect the binding of 3H-Con A to the M phi surface receptor. Second, the binding and internalization of Con A were examined qualitatively by fluorescein isothiocyanate-conjugated Con A (FITC-Con A). After incubation with GST for 72 h, the internalization of FITC-Con A was prominently impaired in vacuolated M phi. A significant inhibition of FITC-Con A internalization was not observed in either GST-treated nonvacuolated M phi or non-GST-treated M phi. Thus the inhibition of FITC-Con A internalization in GST-treated vacuolated M phi seemed to account for the inhibition of 3H-Con A internalization in all the GST-treated M phi populations. The binding of FITC-Con A to the cell surface receptor and the clustering of FITC-Con A receptor complexes were not detectably changed in any of the M phi populations. These results indicated that GST alters the initial step in the activation of M phi by Con A, namely the internalization of this mitogen.(ABSTRACT TRUNCATED AT 250 WORDS)

Concanavalin A↗
PubMedDate not supplied

[Indications for percutaneous transvenous mitral commissurotomy: evaluation according to the Sellors classification].

Fifty-eight consecutive patients underwent percutaneous transvenous mitral commissurotomy (PTMC) for mitral stenosis from August 1987 to June 1990. Patients were divided by echocardiographic characteristics of the mitral valve according to the Sellors classification into three groups: group 1 (mobile cusps, 20 patients), group 2 (thickened cusps, 34 patients), group 3 (rigid cusps, 4 patients). Immediately after PTMC, the mitral valve area increased significantly from 1.41 +/- 0.37 to 2.07 +/- 0.38 cm2 (p < 0.01) in group 1 and from 1.09 +/- 0.21 to 1.64 +/- 0.25 cm2 (p < 0.01) in group 2. The mitral valve area did not increase significantly in group 3 (from 0.82 +/- 0.27 to 1.10 +/- 0.22 cm2). Mitral regurgitation developed or increased in severity in four patients (100%) in group 3 (p < 0.01 vs group 1, 20% and group 2, 21%). The symptomatic improvement was 0% for group 3 (p < 0.01 vs group 1, 90% and group 2, 91%). At follow-up period (mean 24.6 months), symptomatic improvement was maintained in 44 patients (76%) of the total patient population. The mitral valve area was maintained well in group 1 and group 2, but three patients in group 2 showed recurrence of symptoms due to valvular restenosis. PTMC is an effective nonsurgical treatment for patients with mobile or with thickened cusps. Surgical method is preferable for patients with rigid cusps.

Adult↗
PubMedDate not supplied

Correlation between arteriographic and electrocardiographic features during spasm in the left anterior descending coronary artery.

BACKGROUND: The clinical role of collateral vessels, which are transiently augmented during coronary artery spasm, remains controversial. OBJECTIVE: To examine the correlation between coronary arteriographic and electrocardiographic features during spasm in the left anterior descending artery (LAD). METHODS: We studied 45 patients in whom LAD spasms were induced by administration of acetylcholine or ergonovine maleate into the left coronary artery, or in whom spontaneous LAD spasms were documented during diagnostic cardiac catheterization. RESULTS: During spasm, only three patients had transient appearance or augmentation of collateral flow opacifying the LAD. In these three patients, electrocardiograms obtained from anterior precordial chest leads during LAD spasm showed ST-segment depression, ST-segment elevation followed by ST-segment depression, and only T-wave change, respectively. Except for these three patients, ST-segment elevations were observed in all other patients (31 of 34) with main-branch spasm of the LAD. However, ST-segment elevation was observed in only two of 11 patients in whom spasm of the diagonal branch alone was induced. CONCLUSIONS: Our observations suggest that the electrocardiographic changes during spasm are not always a sensitive indicator of LAD side branch spasm or LAD main-branch spasm associated with collateral circulation. From consideration of the angiographic features of the collaterals in the three patients with LAD main-branch spasm, we speculate that the balance of tonus of both the recipient and donor arteries, and the degree of organic stenosis of the recipient artery, may have important roles in the mechanism responsible for the change in the appearance of collaterals in patients with coronary spasm.

Acetylcholine↗