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Biomedical subjects

T Matsubara

Publications and source records attributed to T Matsubara.

At least 559 records · Page 31Linked to original sources
PubMed1976

Characteristics of biliary excretion of cefazolin and other cephalosporins with reference to the relationship between serum levels and administration conditions.

The biliary excretion of cefazolin was compared with that of cephalothin and cephaloridine in rats and man. In rats, the biliary levels were dose-related with cefazolin and cephalothin but not with cephaloridine. Biliary levels were higher than serum levels after injection of 10--80 mg/kg of cefazolin and cephalothin, whereas serum levels of cephaloridine after injection were higher than biliary levels. The highest biliary levels of cefazolin were obtained by intravenous injection, followed by intramuscular injection and drip infusion. In man, a crossover study was made to compare biliary levels of cefazolin with those of cephaloridine and cephalothin. After a single 1-gram intravenous injection, the peak levels of cefazolin ranged from 0.85 to 21 mug/ml and those of cephaloridine varied from 0.55 to 3.9 mug/ml. After a 3-gram intravenous injection, the peak biliary levels of cefazolin ranged from 35.5 to 270 mug/ml and those of cephalothin from 0.3 to 64 mug/ml. The chemotherapeutic biliary levels of cefazolin able to inhibit susceptible organisms were obtained by 3-gram intravenous injections.

Animals↗
PubMed1975

The structure and distribution of ceramide aminoethylphosphonates in the oyster (Ostrea gigas).

1. Ceramide aminoethylphosphonate was isolated from the adductor, gills, mantle and viscera of oysters. 2. After drastic acid hydrolysis of the lipid, aminoethylphosphonic acid was the only water-soluble carbon-phosphorous compound detected. 3. The main fatty acids of ceramide aminoethylphosphonates were hexadecanoic acid (77-90%) and 2-hydroxy hexadecanoic acid (13-15%). 4. Hexadeca-4-sphingenine, octadeca-4-sphingenine and octadeca-4,8-sphingadienine were identified as the major long chain base components. However, the ratio of the three bases was characteristic for each tissue; the adductor muscle contains primarily hexadeca-4-sphingenine, and the viscera, octadeca-4,8-sphingadienine. The gills and mantle contain the three bases in approximately equal concentration. 5. The main molecular species in the adductor muscle was hexadecanoyl-hexadeca-4-sphingenyl 2-aminoethylphosphonate, while in the viscera hexade-canoyl-octadeca-4,8-sphingenyl 2-aminoethylphosphonate predominated.

Aminoethylphosphonic Acid↗
PubMed1975

The participation of cytochromes in the reduction of N20 to N2 by a denitryfying bacterium.

The oxidation of cytochromes during the reduction of N2O to N2 by a denitrifying bacterium was studied spectrophotometrically. The reduced b- and c-type cytochromes are partially oxidized when N2O is added to intact cells reduced with lactate under anaerobic conditions. The oxidation of cytochromes is inhibited non-competitively by azide, cyanide, 2,4-dinitrophenol and CuSO4, which inhibit the reduction of N2O to N2. In the presence of each inhibitor at a high concentration, at which the reduction of N2O to N2 is perfectly inhibited, cytochromes are not oxidized by N2O, while when an adequate, low concentration of inhibitor is added, b-type cytochrome is partially oxidized but c-type cytochrome is apparently not oxidized. In cell-free extracts, prepared by the sonic disruption of cells, that have entirely lost their activity in the reduction of N2O to N2, cytochromes are not oxidized by N2O. From the above results, it was concluded that b-type and c-type cytochromes should participate in the electron transport mechanism of the reduction of N2O to N2.

Alcaligenes↗
PubMed1975

Electron transport systems of lung microsomes and their physiological functions. Enzymic hydroxylation of aniline and steroids.

1. The hydroxylation of aniline by rabbit lung microsomes to rho-aminophenol required oxygen and NADPH, and was inhibited by menadione, ferricytochrome c and carbon monoxide. 2. NADH was a less effective electron donor than NADPH in this reaction, but its addition significantly increased the yield of rho-aminophenol formed in the presence of NADPH. 3. 4,16-Androstadien-3-one and 3beta-hydroxy-5-androsten-17-one were also metabolized by lung microsomes to the same products as are formed by hepatic microsomes.

Androstadienes↗