Paget's disease associated with myelofibrosis and myeloid metaplasia--a common pathophysiology ?
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Aged↗
Biomedical subjects
T Matias
Publications and source records attributed to T Matias.
Motor neuron disease presenting with respiratory failure.
Respiratory failure accounts for the majority of deaths in amyotrophic lateral sclerosis (ALS) but only rarely is ALS diagnosed on the basis of respiratory insufficiency. We report four ALS patients presenting with acute respiratory failure. In three patients we have performed EMG needle examination of both hemidiaphragms which showed severe denervation. We reviewed 25 patients previously described presenting with respiratory failure. Almost all patients showed upper limbs weakness and diaphragm involvement; few patients had bulbar dysfunction. The prognosis of these patients is not always in permanent ventilator dependence. Rapidly progressive ventilatory failure may be a striking initial sign of ALS; the main reason is a weakened diaphragm. There are possibilities of significant improvement after a period of rest with ventilatory assistance. In the initial phase of the disease, bulbar dysfunction is not the more common reason of acute respiratory failure.
Aged↗
[Multiple endocrine neoplasia type IIb].
We describe the clinical manifestations of a multiple endocrine neoplasia, type IIb, in a 32 year old woman, admitted to a general hospital with intestinal sub-occlusion. The phenotype associated with bilateral pheochromocytomas show us the diagnosis, but the unsolved problem is the high levels of calcitonin, without macroscopic evidence of tumor relapse.
Adult↗
[Adenocarcinoma of the colon disclosed by endocarditis caused by Streptococcus bovis].
The association of Streptococcus bovis endocarditis with colonic neoplasms has been well documented. We describe a patient in whom the finding of a Str. bovis endocarditis stimulated investigation which resulted in the diagnosis and surgical treatment of an adenocarcinoma of the colon.
Adenocarcinoma↗
[Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology].
Although megaloblastic anemias are generally regarded as chronic conditions of insidious appearance, a megaloblastic state can arise over the course of only a few days due to acute folate or vitamin B12 deficiency. One of the most common causes, though seldom reported, is the nitrous oxide (N02) action in tissue. In fact N02, a volatile substance commonly used in anaesthesia, destroys methylcobalamin, leading to the rapid development of a megaloblastic haematopoiesis. This phenomenon may occur in patients without previous vitamin B12 deficit, but is more frequent and severe when there is a pre-existent deficiency state. A case report is described of a patient with femoral fracture who developed acute anemia after surgery and a latent pernicious anemia was revealed upon investigation.
Acute Disease↗