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Biomedical subjects

T Mannen

Publications and source records attributed to T Mannen.

At least 127 records · Page 7Linked to original sources

The Onuf's nucleus and the external anal sphincter muscles in amyotrophic lateral sclerosis and Shy-Drager syndrome.

The anterior sacral horns and external anal sphincter muscle were examined histologically with special reference to Onuf's nucleus in amyotrophic lateral sclerosis (ALS) and Shy-Drager syndrome. Onuf's nucleus and the external anal sphincter muscles were well preserved in ALS, but in Shy-Drager syndrome both structures showed marked degenerative changes. These findings suggest that Onuf's nucleus does not belong to the autonomic neurons, but to the motoneurons in anterior sacral horn, and it innervates the external sphincter muscles of the anus and urethra.

Aged↗

Cervical radiculomyelopathy due to calcified ligamenta flava.

Two cases of cervical radiculomyelopathy were apparently caused by calcification of the ligamenta flava. Similar cases have not previously been described, although myelopathy due to calcified thoracolumbar ligamenta flava is occasionally reported. Radiological study is necessary for diagnosis. Surgical removal of the calcified masses was followed by improvement in the symptoms. In 1 patient, the disease was associated with pseudogout in the menisci of the knee joints, pubic symphysis, and acetabular lips. The cause and pathogenesis of this rare condition are unknown.

Aged↗

Preservation of a certain motoneurone group of the sacral cord in amyotrophic lateral sclerosis: its clinical significance.

Histopathological description of a special nerve cell group of the sacral spinal cord in five cases of amyotrophic lateral sclerosis is presented. Remarkable preservation of this group of neurones (the X group of Onuf) was noted in each case, and this is discussed with particular reference to vesicorectal function, since it is well known that the function of bladder and rectal sphincters is often intact until the latest stage of the illness.

Adult↗