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Biomedical subjects

T Maki

Publications and source records attributed to T Maki.

At least 271 records · Page 15Linked to original sources
PubMed1977

En bloc transplantation of the liver, pancreas, duodenum, spleen, and kidney in the rat.

Five organs consisting of the liver, pancreas, duodenum, spleen, and kidney from (Lewis X Brown Norway)F1 rats were transplanted simultaneously as an en bloc graft to Lewis recipients. No immunosuppression was given postoperatively. Serial laporatomies were performed for macroscopic examination and biopsies of the grafts. Macroscopically, the first evidence of rejection was splenic enlargement followed by fatty metamorphotic change of the liver, dilation and loss of peristalsis of the duodenum, and injection of the pancreas. The kidney maintained normal color and consistency until late in the rejection process. Histological examination suggested that the liver and the spleen may be more vulnerable to immune attack, since in these organs cellular infiltration started earlier and was more extensive in comparison to other organs. While the pancreas exhibited a typical, although somewhat delayed rejection pattern, the kidney seemed to maintain a well preserved structure. Interestingly, the duodenum showed no significant cellular infiltration throughout the postoperative period of examination despite severe mucosal destruction.

Animals↗
PubMed1977

Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones.

The authors reported previously that beta-glucuronidase in bile, especially during biliary infection with Escherichia coli, plays a substantial role in producing cium bilirubinate gallstones. In the present study, bile levels of glucaro-1:4-lactone (measured as glucaric acid) the leading inhibitor of beta-glucuronidase, were measured in both man and in rats fed high, medium, and low protein-fat diets. Glucaric acid and total bilirubin in bile correlated well in human controls but not in gallstone patients. In animal experiments, the levels of these substances in bile were high in rats on high protein-high fat and low in those on low protein-low diets. These data suggest that when bile is infected with E. coli, calcium bilirubinate gallstones seemed to form more easily in patients on low protein-low fat diet than in those consuming food rich in protein and fat. On the other hand, the ratio of lecithin to cholesterol was higher in low protein-low fat rats than in high protein-high fat rats, suggesting that cholesterol gallstones were more likely to form on the latter diet. The animal, clinical, epidemiological, and dietary data are consistent with the known trend to a decreased incidence of calcium bilirubinate and an increased incidence of cholesterol gallstones in Japan.

Animals↗
PubMed1977

[Study of S-6437 (sustained release cephalexin) in pediatrics (author's transl)].

In order to clinically evaluate S-6437, the following study was carried out in pediatric patients. This clinical study was performed in 30 patients ranging from 2 years and one month to 10 years and one month of age. Seven patients had scarlet fever, 3 acute pharyngitis, 4 acute suppurative tonsillitis, 6 acute bronchitis, 2 acute pneumonia, 3 acute pyelonephritis, 1 chronic pyelonephritis, 2 vaginitis, 1 acute gastro-enteritis, and 1 impetigo. The degree of these diseases were all mild or moderate. These patients were orally administered 35 approximately 50 mg/kg/day in two divided doses for 3 approximately 10 days. As a result, effectiveness of this preparation in these patients was 80% and no side effects were observed.

Acute Disease↗
PubMed1976

Primary in vitro sensitization of murine lymphocytes against isogeneic and allogeneic cells transformed by simian virus 40.

Primary in vitro sensitization of murine lymphocytes to isogeneic and allogeneic cells transformed by simian virus 40 (SV40) is described. The results of specificity studies utilizing cytotoxic effector lymphocytes obtained by in vitro immunization indicate that SV40 transformation results in the expression of tumor-specific antigens which are recognized by cytotoxic effector cells. Moreover, the studies demonstrate that expression of tumor-specific antigens on transformed cells is associated with a reduction in the functional expression of normal histocompatibility antigens.

Animals↗
PubMed1975

Pylorus-preserving gastrectomy for gastric ulcer--one- to nine-year follow-up study.

Of 100 patients subjected to pylorus-preserving gastrectomy for surgical treatment of gastric ulcer, 60 were available for follow-up for periods of from one to 9 years. Questionnaires and personal interviews of these 60 and additional laboratory examinations of 40 of them showed results tending to favor the procedure as a highly recommendable technique of gastrectomy. Questions about body weight gain, return to preoperative occupation, and satisfaction with the operation all were answered favorably. In the follow-up laboratory examinations, reduction rates of 57.2 percent for maximal acid concentration, 81.6 percent for maximal acid output, and 70.8 percent for peak acid output. Sphincteric function was generally well preserved on the pyloric ring. Gastric emptying times, ranging from 30 to 180 minutes in 79 percent of the cases, were nearly compatible with the control figures. The results of fat and protein absorption tests performed on some of these patients showed their rates to be within normal ranges. No instances of dumping syndrome, recurrence of ulcer, or other significant postgastrectomy sequelae were recognized. The results indicate pylorus-preserving gastrectomy to be preferable for the surgical treatment of gastric ulcer and other benign lesions of the stomach.

Adult↗