Search PubMed⌕ Search

Biomedical subjects

T Maeda

Publications and source records attributed to T Maeda.

At least 1,477 records · Page 82Linked to original sources
PubMed1980

Comparison of hemodynamics induced by conventional acetate hemodialysis, bicarbonate hemodialysis and ultrafiltration.

Six patients on conventional acetate hemodialysis who had a marked decrease in total peripheral resistance index (TPRI) and hypotension after dialysis were selected for study. Systemic hemodynamic factors such as cardiac output, blood pressure, hematocrit and heart rate were measured, and the values were compared to those found after bicarbonate hemodialysis (Bi-HD) or ultrafiltration without simultaneous dialysis (UF) in the same patients. After Bi-HD and UF, the hemodynamic indices remained stable. Hematocrit level was significantly elevated after Bi-HD (+2.7%, P less than 0.05). Heart rate was insignificantly increased after each procedure. We concluded that Bi-HD can prevent unpleasant side effects induced by the decrease in TPRI with acetate hemodialysis. The stability of TPRI resulting from the increase in hematocrit level during Bi-HD may contribute to the prevention of cardiovascular instability.

Acetates↗
PubMed1979

Cerebral contribution to the visual suppression of vestibular nystagmus.

Thirty-two patients with cerebral lesions were examined to locate cerebral areas involved in visual suppression. Visual suppression was reduced or abolished when the lesions were in the parietal lobe, especially in the dorsoposterior region. This part of the parietal lobe seems to modify visual suppression of caloric nystagmus that is mediated by the flocculus and nodulus of the cerebellum as well as the pons. In patients with frontal lobe lesions including the parietal lobe, visual suppression was reduced or abolished. Thus, the parietal lobe is important for this visual suppression mechanism.

Adult↗
PubMed1979

Use of rabbits for GI drug absorption studies: relationship between dissolution rate and bioavailability of griseofulvin tablets.

The correlation between the dissolution rate and bioavailability of griseofulvin tablets was studied in stomach-emptying-controlled rabbits and in humans. Three different test tablets, each consisting of two dose levels (62.5 or 125 mg) of griseofulvin, were used. The dissolution rates in 0.5 hr were approximately 75, 40, and 12%. With oral administration at 62.5 mg/rabbit, the ratio of peak plasma level, Cmax, was 1.00:0.66:0.40 and that of the area under the curve (AUC) was 1.00:0.73:0.46 for the three tablets. The corresponding C'max ratio was 1.00:0.74:0.34 and the AUC ratio was 1.00:0.72:0.33 in humans at the dose level of 500 mg. A good correlation was observed for the rank order of Cmax and AUC between rabbits and humans, but such a correlation was not seen between in vivo data and in vitro data at a larger dose of 125 mg/rabbit. This finding was attributable to the dose, which exceeded the GI drug dissolution or absorption capacities. These results suggest that the stomach-emptying-controlled rabbit is useful for evaluating oral dosage forms for human use and that dose level selection is important in the bioavailability study of a barely water-soluble drug.

Administration, Oral↗
PubMed1979

Specificity of memory cells raised against trinitrophenyl-conjugated syngeneic cells.

Exogenous lipid analogues can be incorporated into purified plasma membranes of EL4 tumor cells. When EL4 membranes are incubated with sonicated lipid vesicles containing spin-labeled phosphatidylcholine and then purified, they exhibit paramagnetic resonance spectra characteristic of spin labels dilutely dispersed in the lipid bilayer. Also, when EL4 membranes are incubated with vesicles of fluorescent lipid (N-4-nitrobenzo-2-oxa-1,3-diazole phosphatidylethanolamine), the fluorescence intensity of the mixture gradually increases and the labeled membranes are strongly fluorescent under a microscope, whereas the original lipid vesicles are much less fluorescent because of self-quenching at the high relative concentration of the fluorophore in the vesicles (33%, wt/wt). Thus, lipid analogues can be integrated into the bilayers of EL4 plasma membranes. The ability of the EL4 membranes containing trinitrophenyl phosphatidylethanolamine to induce a secondary proliferation of C57BL/6 mouse spleen lymphocytes primarily stimulated by trinitrophenyl-modified autologous cells was investigated. Although trinitrophenyl-modified plasma membranes as well as trinitrophenyl-modified lymphocytes or EL4 cells caused a specific, H-2 restricted response, membranes containing trinitrophenyl phosphatidylethanolamine did not induce a secondary proliferative response. Because of the strong likelihood that all three lipid analogues mentioned above are similar to one another in having a high lateral mobility and in not being strongly associated with H-2 cell-surface molecules, these results can be viewed, with caution, as being consistent with a "modified self" model rather than a dual recognition model for H-2 restriction in the cell-mediated immune response to chemically modified syngeneic cells.

Animals↗
PubMed1979

Physicochemical properties of pyocin F1.

The physiochemical properties of pyocin F1 were studied. Pyocin F1 consists of flexuous rod-like particles homogenous in size. Each particle was composed of rod and fiber parts. The rod part was 105.5 +/- 9.5 nm long and 10.0 +/- 1.4 nm wide, and showed regular striations amounting to 23 layers. The fiber part was composed of several filaments; the length of the longest filament was 43.0 +/- 12.0 nm. The amino acid composition, the partial specific volume (0.720 ml/g), the sedimentation coefficient (S020,W = 35.1S), and the translational diffusion constant (0.94 +/- 0.01 x 10(-7) cm2/s) were determined. The particle weight was calculated to be 3.23 x 10(6) daltons.

Amino Acids↗
PubMed1979

Oral temperatures in young and old people.

Oral temperatures were measured in ten young females and ten young males, and compared to oral temperatures measured in ten elderly females and ten elderly males. Each subject had a complete natural dentition. When analysed by sex, it was found that the temperatures in elderly males were lower than in young males (P less than 0.001), while temperatures in young and elderly females did not differ. Concerning sublingual temperatures, a difference of approximately one-third of a degree centigrade was demonstrated between the two age groups (P less than 0.005).

Adult↗
PubMed1979

Crevicular temperature rises stimulated by plaque formation.

In nineteen subjects, temperatures were recorded thermo-electrically in the vestibular and proximal crevices of fifty-nine teeth. It was found that the formation of a new plaque was followed by a rise in crevicular temperature. In addition, it was found that the normal as well as the abnormal crevicular temperatures were higher in the mandible than in the maxillae.

Adult↗
PubMed1979

Mucosal temperature rises following long-term use of full dentures.

Mucosal temperatures were studied in twenty-two subjects, who had worn full upper and lower dentures for at least 5 years. By comparing with a group of twenty-two fully dentate subjects, it was found that in the denture wearers, temperatures were increased significantly in the lower jaw, but not in the upper jaw.

Aged↗
PubMed1979

Turner's syndrome with a duplication-deficiency X chromosome derived from a maternal pericentric inversion X chromosome.

A 31-year-old woman of short stature with severe oligomenorrhea was found to carry a duplication-deficiency X chromosome, 46,X,rec(X)dup q,inv(X)(p22q11), inherited from her mother who carried a pericentric inversion X chromosome, 46,X,inv(X)(p22q11). By a combination of autoradiography and BUdR incorporation, the duplication-deficiency X chromosome was always found to be the inactive and late replicating one. In the cultured fibroblasts with the recombinant X chromosome, some of the cells were seen to have bipartite X chromatin bodies. In the mother with inv(X), the normal and the inverted X chromosome were inactivated at random.

Adult↗