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Biomedical subjects

T Maeda

Publications and source records attributed to T Maeda.

At least 1,441 records · Page 80Linked to original sources

Electron microscopic observations of concentric lamellar bodies within mesenchymal cells of anagen hair dermal papilla.

The presence of 2 forms of the concentric lamellar bodies was observed in the mesenchymal cells within dermal papilla of normal scalp anagen hairs. They are those composed of agranular membrane arrays in association with beta-glycogen particles (glycogen bodies) and those of smooth-surfaced endoplasmic reticulum (smooth-surfaced lamellar bodies). On rare occasions these 2 forms of the concentric lamellar bodies were simultaneously present within the same cells. Transitional forms between the smooth-surfaced lamellar bodies and phagosegresomal granules were also encountered.

Adolescent↗

Effect of toothbrush stimulation on temperature of gingival and alveolar mucosae.

Thermometry was used to study the effect of applying a toothbrush to three types of oral mucosae, in forty dental students. Brushing with an electric tooth brush resulted in an immediate fall in temperature, but 3 min later the temperature was significantly higher than before stimulation. The temperature changes were greater in gingival crevice and attached gingiva compared with alveolar mucosa. Moreover, it was found that a static application of the toothbrush produced temperature changes which were equal to those following a dynamic application.

Adult↗

Host response to two different designs of minor connector.

Temperatures were recorded in thirty-two gingival crevices adjacent to proximal surfaces of abutment teeth fitted with minor connectors of an open space design, and in thirty gingival crevices adjacent to proximal surfaces fitted with minor connectors of a closed design. During the 2 week experimental period, the twenty-seven removable partial denture subjects who were involved in the study kept the accumulation of plaque to a minimum by applying specialized tooth-brushing. Although an equal but small amount of plaque formed in both groups, the presumed minimal rise in temperature stimulated by this plaque did not prevent the two connector designs from showing disparate effects on the crevicular temperature. It was concluded that the open space design of minor connector is less conducive to irritation of the adjacent marginal gingiva than is the closed design.

Dental Plaque↗

Concatenation of variations in plaque formation with variations in crevicular temperature.

The hypothesis was tested that variations in the temperature of gingival crevices are linked to variations in plaque formation. Fifty-nine abutment teeth to removable partial dentures were studied during four experiments, under various conditions of plaque formation, i.e. not brushing the teeth whilst wearing and not wearing dentures, and performing ordinary and then specialized tooth brushing whilst wearing dentures. The collation of temperature curves with plaque curves revealed a proportional relationship between the rate and magnitude of plaque formation and the rate and magnitude of the recorded temperature changes. Furthermore, the removal of plaque resulted in a reversal of induced temperature rises. The lowest crevicular temperatures were obtained with the practice of the specialized tooth brushing.

Adult↗

Cystosarcoma phyllodes of the breast with features of malignant fibrous histiocytoma.

A case of a 33-year-old female with metastasizing malignant cystosarcoma phyllodes of the left breast showing histologic features of malignant fibrous histiocytoma is reported. Metastases consisting of only undifferentiated mesenchymal cells were found in the lungs, liver, pleurae, kidneys, ileum, and vertebrae. Seven cases of fibrohistiocytic tumors of the breast previously recorded in the literature were reviewed. Although rare, this type of tumor should be included in the differential diagnosis of mesenchymal mammary tumors.

Adult↗

Subxiphoid cross-sectional echocardiographic imaging of the "goose-neck" deformity in endocardial cushion defect.

The cross-sectional echocardiographic demonstration of the "goose-neck" deformity is described in four patients with endocardial cushion defect. The diagnosis was confirmed in each patient by left ventricular angiocardiogram. The subxiphoid approach of cross-sectional echocardiography in diastole allowed visualization of an elongated, narrowed, and somewhat horizontally inclined configuration of the left ventricular outflow tract, which appeared almost identical to that obtained by angiocardiography. In systole, the right border of the left ventricle was composed of the cleft anterior mitral leaflet, the left-sided line of which was convex toward the left ventricular cavity. The mitral valvular echoes were thickened, jagged and irregular, which seemed to correspond to the scalloped appearance of the right border of the left ventricular silhouette in a systolic phase of the left ventricular angiocardiogram. There were no obvious differences between the goose-neck configuration of complete-type endocardial cushion defect and that of ostium primum atrial septal defect.

Echocardiography↗

Infectious sialodacryoadenitis and rat breeding.

The littering rate of female rats was significantly lowered when they had been exposed to sialodacryoadenitis early in pregnancy. Rats of 8 weeks or more of age were highly susceptible to contact infection, showing marked decrease in bodyweight gain, whereas those of 5-6 weeks of age were resistant.

Animals↗

Difference of subtypes of hepatitis B surface antigen between asymptomatic carriers and patients with chronic liver diseases.

Subtypes of hepatitis B surface antigen (HBsAg) were studied in 20 asymptomatic HBsAg carriers and 18 HBsAg-seropositive patients with chronic hepatitis or live cirrhosis. Among them 25 were university students. In the male university students, subtypes adw was found to be significantly higher in asymptomatic HBsAg carriers than in patients with chronic hepatitis (p=0.04). The difference in subtypes of HBsAg between male asymptomatic carriers and male patients with liver disease was further confirmed by the combined results of university students and other subjects (p=0.007).

Adult↗

Elevation of glutamic pyruvic transaminase and gamma-glutamyl transpeptidase in obesity.

Study was made of glutamic pyruvic transaminase (GPT), glutamic oxalacetic transaminase (GOT), and gamma-glutamyl transpeptidase (gamma-GTP) in 729 obese subjects in various groups, namely, primary school children, high school children, university students, and outpatients. The incidences of abnormal GPT, GOT, and gamma-GTP in the obese subjects were frequently significantly higher than in the controls. It was most clearly shown in GPT. The incidences of abnormal GPT in the obese females were significantly lower than those in the obese males, but were significantly higher than the controls. Higher incidences of abnormality in the school children were ascribed to the higher degree of obesity in the children. The extent of increase in GPT was considerable. GPT was sometimes higher than 6 times the normal upper limit.

Adolescent↗

Effect of neonatal administrations of 6-OHDA on the brain development. I. Alteration in the striatum.

Following repeated subcutaneous administrations of 6-OHDA into neonatal rats (a dose; 100 mu/g bw), the effect on the brain development was examined. The striatal dopamine fluorescence never disappeared completely even immediately after multiple administrations of 6-OHDA, however a slight reduction of the fluorescence lasted for a long time. Semithin sections stained with toluidine blue showed numerous dark necrotic neurons appearing at a 15-times higher ratio than that in controls. Such necrotic neurons always accompanied a few granular deposits around the wavy surface. In a certain area of the striatum (0.898 mm2), there were no clear changes in the cell population in neurons and glia, in the ratio of glia to neurons, and in the ratio of each cell type of glia to the total glia, but some neuronal cell loss was speculated to occur slowly. The ultrastructural alteration observed at 28, 35 and 42 postnatal days in 6-OHDA treated rats was characterized by an appearance of myelin-like membranous lamellar bodies in the boutons synapsing with neural soma. In some cases intact small synaptic vesicles were seen around the lamellar body which probably rose from cell membranes in the synaptic area. Most of the necrotic neurons corresponded to the post-synaptic side for the boutons including lamellar bodies. Necrotic neurons displayed a dense cytoplasmic matrix, an increase of polysomes and cisternal swelling in rough ER and in the Golgi apparatus. Membranous lamellar bodies were occasionally observed in the periphery of satellite glial cells, probably oligodendrocytes. In conclusion, a long lasting reduction of striatal dopamine caused by 6-OHDA might disturb the function around the synaptic area and the metabolic regulation in the post-synaptic striatal neuron, thus resulted in the appearance of rather chronic morphological alterations in those areas.

Animals↗