Search PubMed⌕ Search

Biomedical subjects

T Maeda

Publications and source records attributed to T Maeda.

At least 1,333 records · Page 74Linked to original sources
PubMed1983

[Ascending and descending projections of posterior hypothalamus neurons immunoreactive to serotonin after administration of 5-hydroxytryptophan in cats].

Through combined retrograde labeling with HRP and serotonin immunohistochemistry, we have demonstrated that ventral and caudal hypothalamic neurons, both non-immunoreactive and immunoreactive to serotonin after administration of 5-hydroxytryptophane, give rise to direct ascending projections to the entire cerebral cortex as well as direct descending projections to the nucleus locus coeruleus alpha in the pontine tegmentum. A retrograde double labeling method with fluorescent dyes further suggested that the population of ascending hypothalamic neurons is different from that of descending ones.

5-Hydroxytryptophan↗
PubMed1983

[Clinical manifestations, therapeutic methods and prognosis of patients with ischemic cardiomyopathy].

In view of the increased prevalence of so-called "ischemic cardiomyopathy" ( Burch ) in Japan, we attempted to clarify the clinical manifestations of this condition and to investigate the medical treatment in comparison with the surgical therapy. Eighteen patients (17 males and one female) were identified as having "ischemic cardiomyopathy" according to the following criteria: These include (i) an ejection fraction of 30% or less with asynergy on all segments of AHA classification, (ii) significant coronary stenosis (75% or more) of one or more major coronary branches, and (iii) no other coexisting lesion, such as primary valvular disease or congenital heart disease. In the history, distinct myocardial infarction or angina pectoris was observed in 10 cases (56%), and in the remaining eight cases (44%) only symptoms of cardiac failure was shown. On the ECG, all cases showed pathologic Q waves. Moreover, 10 cases (56%) of these had Q waves in five leads or more. Cardiomegaly on the chest X-ray film (CTR greater than or equal to 60%) was evident in 10 cases and that on echocardiogram ( LVDd greater than or equal to 60 mm) in 16 cases. Physical examinations demonstrated gallop sounds in 89% and a B-B' step formation on echocardiograms in 50%. The LVEDP was greater than 12 mmHg in 13 cases, and the systolic pressure of the pulmonary artery was higher than 35 mmHg in 13 cases. On the other hand, the reduced cardiac index (less than or equal to 2.21/min/M2) was observed in only one case. Selective CAG revealed multiple vessel disease in 78%. Ten of the 18 cases had mitral regurgitation demonstrated by left ventriculography.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Visualization of peripheral left coronary aneurysms in Kawasaki disease by subcostal two-dimensional echocardiography].

Our previous study provided a new two-dimensional echocardiographic technique for detecting peripheral "right" coronary artery aneurysms in Kawasaki disease using a subcostal approach. In the present paper, we presented an additional study for detecting peripheral "left" coronary artery aneurysms. Because the left anterior descending artery runs along the anterior interventricular sulcus and the left circumflex artery around the mitral valve ring, both coronary regions are difficult to search by a conventional method. Then coronary aneurysms of these regions were searched using the subcostal approach in this study. First, the sector beam was directed toward the heart on a plane parallel to a line between the patient's shoulders which allowed simultaneous visualization of four chambers (P1). The area around the mitral valve ring in this plane was examined for coronary aneurysms of the peripheral left circumflex artery. Secondary, the beam section was positioned parallel to the line cutting both the long axes of the sternum and spinal column which allowed visualization of the right ventricular outflow tract, pulmonary valves, interventricular septum, mitral valves and left atrium (P2). Thirdly, the sector plane was angled to the left (P3), and still more to the left (P4) until the left atrium just disappeared. By scanning from P2 to P4, the area around the mitral valve ring was examined for coronary aneurysms of the peripheral left circumflex artery. By scanning from P4 to the cardiac apex (P5), the anterior interventricular sulcus was searched for coronary aneurysms of the peripheral left anterior descending artery. Of 143 patients with Kawasaki disease, aged two months to 8 years, 7 peripheral left coronary aneurysms were visualized in five patients. These were three aneurysms in the left circumflex artery at the origin of the obtuse marginal artery, two aneurysms in segment 13, and two aneurysms in the left anterior descending artery at the origin of the second diagonal branch. These echocardiographic features coincided well in size, shape and anatomic location with angiographic appearances. In one patient whose echocardiogram in sector P2 showed a small echo-free space (2 X 2 mm) at the area around the mitral valve ring, the angiographic study showed the intact left circumflex artery, suggesting that there was a limitation to distinguish a very small coronary aneurysm from a normal one. There was no false negative diagnosis. These results showed that this new echocardiographic technique is useful for detecting peripheral left coronary aneurysms in patients with Kawasaki disease.

Aneurysm↗
PubMed1983

Study of atrial contraction in sick sinus syndrome using conventional and esophageal echocardiography.

To evaluate the active systolic function of both atria in sick sinus syndrome (SSS), conventional and esophageal echocardiograms were recorded in 22 normal subjects (Normal), 5 patients (pts) with sinus bradycardia (Group I), 9 with sinoatrial block or sinus arrest (Group II), 10 with bradycardia-tachycardia syndrome (BTS, Group III) and 6 with transient atrial fibrillation (Group IV). Two pts in Group II and 8 in Group III had a history of syncope. Atrial filling fraction obtained by the left ventricular echogram (AFF by LV echo) and posterior wall excursion of the aorta during atrial contraction (Ea) were determined by the conventional echocardiogram. The excursion of the interatrial septum during atrial contraction (Eb) and the dimensional shortening of the right atrium during atrial contraction (Ec) were determined by the esophageal echocardiogram. Results were as follows: AFF was almost the same in Normal, and Group I, II and IV, but it was significantly lower in Group III. AFF was also decreased in 2 pts in Group II who had a history of syncope. Both Ea and Eb in Group III were significantly lower than those in the other groups. Ec was not significantly different among all groups, although one patient in Group III had markedly decreased Ec. There was a significant correlation between Ea and AFF (r = 0.638, p less than 0.001). We conclude that in a number of cases with SSS, especially BTS, left atrial active contraction is significantly impaired in addition to the electrophysiological abnormality.

Adult↗
PubMed1983

Effective bromocriptine treatment of a pituitary macroadenoma during pregnancy.

A 32-year-old woman with 5 years of oligomenorrhea and 2 years of amenorrhea became pregnant after ovulation induced by clomiphene citrate, human menopausal gonadotropin, and human chorionic gonadotropin. Although there were no neurologic or ophthalmologic symptoms before pregnancy, ptosis and diplopia developed progressively from 14 weeks' gestation. Physical, radiologic, and laboratory examinations revealed hyperprolactinemia with pituitary macroadenoma. In an attempt to delay surgery, 7.5 mg bromocriptine was administered daily. The serum prolactin level was lowered and clinical symptoms improved with bromocriptine treatment. The pregnancy continued uneventfully and normal twins were born at 39 weeks' gestation. Two weeks after delivery, a transsphenoidal hypophysectomy was performed.

Adenoma, Chromophobe↗