Search PubMed⌕ Search

Biomedical subjects

T Machida

Publications and source records attributed to T Machida.

At least 325 records · Page 18Linked to original sources
PubMed1977

Surgical treatment and adjuvant chemotherapy of gastric cancer on the basis of pathological findings.

Gastrectomy was performed in 626 outo 692 operated cases of gastric cancer. Histologic examination of the resected specimens revealed that the cancer was confined to the mucosal (m) or submucosal layer (sm) in 256 cases, advanced to the muscularis propria (pm) or subserosal layer (ss) in 110, and to the serosa (se) or the surrounding organs (si, sei) in 260. 238 (93%) of m and sm cases were free from lymphnode metastasis. Lymphnode metastasis was noted in 51 (46%) of pm and ss cases, 177 (77%) were positive in lymphnode metastasis and 108 (47%) showed metastasis in n2 and n3 degree. Adjuvant chemotherapy fairly improved the psotoperative survival rate of the advanced cases with lymphnode metastasis, serosal involvement, or lymph and blood vessel involement of gastric cancer.

Adult↗
PubMed1977

Basic studies of various 99mTc-labelled renal agents and clinical application of 99mTc-malate.

Various renal imaging agents that were reported in the past and a new agent, 99mTc-malate as well as99mTc-cystein acetazolamide complex were prepared using electrolysis and electrochemical methods. These were studied for their labelling efficiency. After animal experiments with selected 99mTc-compounds, 99mTc-malate proved to be sufficient for renal imaging with adequate concentration. 99mTc-malate differs from other renal imaging agents in the utilization of endogeneous metabolic product. The first half time of 99mTc-malate in humans is 17 minutes, on the average, and the urinary excretion rate of 99mTc-malate is 36+/-6.05% in 1 hour after intravenous administration, 44+/-3.41% in 2 hours and 50+/-5.62% in 3 hours. In our 40 clinical experiences of 99m-Tc-malate, most cases demonstrated quite clear renal images in the serial scintiphotos except cases whose serum creatinines were over 4.5 mg/dl.

Acetazolamide↗