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Biomedical subjects

T M Sundt

Publications and source records attributed to T M Sundt.

At least 235 records · Page 13Linked to original sources
PubMed1975

Management of ischemic complications after subarachnoid hemorrhage.

The author reviews a form of management for patients deteriorating preoperatively or postoperatively from apparent ischemia attributed to progressive vasospasm after a subarachnoid hemorrhage. The clinical picture and relative frequency of this complication are considered in relationship to the status (grade) of the patient, location of the aneurysm, and ultimate neurological recovery. Experience suggests that the drug regimen reported is useful when instituted early after the onset of symptoms and is safe with proper monitoring techniques. The data do not justify early operative intervention after a subarachnoid hemorrhage, operation when there is angiographic evidence of severe spasm, or expectation of a dramatic effect in patients with a profound deficit or a fixed deficit several hours old.

Adult↗
PubMed1975

Microcirculatory obstruction in focal cerebral ischemia. Relationship to neuronal alterations.

The cerbral microcirculation in squirrel monkeys was studied by the carbon perfusion technique after middle cerebral artery occlusion. No filling impairment was detected with 90 minutes of ischemia, and only slight impairment was detected with 3 hours of ischemia. Severe microcirculatory obstruction was found after ischemia longer than 3 hours. The obstruction appeared to be at the capillary level and seemed partly the result of narrowing of cappillary channels by perivascular glial swelling and developing cerebral edema. The relationship between the developing microcirculatory obstruction and the distribution and severity of the neuronal alterations was studied. The results of this investigation using the same experimental model suggest that obstruction of parenchymal vessels does not play a major role in the production of an infarct in areas of acute focal ischemia.

Animals↗
PubMed1975

Carotid endarterectomy. Complications and preoperative assessment of risk.

A system of grouping patients according to preoperative evaluation of risk of carotid endarterectomy is presented. The primary complications of this surgical procedure were myocardial infarction and residual mild to severe neurologic deficit. Neurologically stable patients without medical or angiographically determined risk factors (group 1, 129 patients) have a risk of 1%. Neurologically stable patients without medical risk but with angiographically determined risk (group 2, 56 patients) have a risk of 2%. Neurologically stable patients with significant medical illness and with or without angiographically determined risks (group 3, 76 patients) have a risk of 7%, primarily related to cardiac disease. Neurologically unstable patients (group 4, 70 patients) have a 10% risk for a neurologic deficit.

Angiography↗