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Biomedical subjects

T M Reilly

Publications and source records attributed to T M Reilly.

78 records · Page 5Linked to original sources
PubMed1976

Physiological dependence on, and symptoms of withdrawal from, chlormethiazole.

The uses of chlormethiazole (Heminevrin) are briefly mentioned. Differing views of its potential for producing dependence are discussed. The consensus opinion is taken to be that a risk of psychological dependence does exist, but only one case has appeared in the medical literature to date of physiological dependence on chlormethiazole, with withdrawal symptoms. This case is re-examined. A second case is described in which the features of increasing dosage and withdrawal were followed by confusion, disorientation, delusions, hallucinations and muscular spasm and coarse jerking. This is taken as confirmation of the potential of chlormethiazole to produce physiological dependence. Some personal opinions of the author regarding indications for use and incidence of abuse are briefly mentioned.

Adult↗
PubMedDate not supplied

Amino acid sequence determination of three monoclonal antibodies to angiotensin II.

To relate the immunochemical specificity of three murine monoclonal antibodies directed against the octapeptide hormone angiotensin II (AII) to their primary structure, we have sequenced mRNA for the variable regions of their heavy and light chains. Comparison of the sequences indicates that each of the antibodies utilize very closely related V genes in both heavy and light chains. Two of these antibodies, ICH2 and ICA10, display an epitope preference for the carboxy terminus of AII. A third monoclonal antibody, KAA8, displays a lesser specificity for the carboxy terminus of AII than either ICH2 or ICA10. This antibody differs in sequence from the others mainly in the light chain complementarity determining regions (CDR) 1 and 3 and in CDR 3 (D region) on the heavy chain. We interpret these sequence differences as the basis for the observed specificity preferences.

Amino Acid Sequence↗
PubMedDate not supplied

Helping halt hypothermia. An overview of in-line blood/solution warmers.

Preventing hypothermia when delivering fluids to a patient is of critical importance. Several varieties of fluid warmers are available to help prevent hypothermia. Before deciding which model of warmer to use, health care facilities must decide when they will use this technology.

Blood Transfusion↗